Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.

Autor: Ridnour LA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Heinz WF; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Cheng RYS; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Wink AL; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Kedei N; Collaborative Protein Technology Resource (CPTR) Nanoscale Protein Analysis, Office of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Pore M; Imaging Mass Cytometry, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Imtiaz F; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Femino EL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Gonzalez AL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Coutinho LL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.; Center for Translational Research in Oncology, ICESP/HC, Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, Brazil., Moffat RL; Optical Microscopy and Analysis Laboratory, Office of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Butcher D; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland., Edmondson EF; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland., Li X; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia., Rangel MC; Center for Translational Research in Oncology, ICESP/HC, Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, Brazil., Kinders RJ; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Rittscher J; Institute of Biomedical Engineering, Big Data Institute, Ludwig Oxford Branch, University of Oxford, Oxford, United Kingdom., Lipkowitz S; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Wong STC; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas., Anderson SK; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., McVicar DW; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Glynn SA; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Billiar TR; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Chang JC; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas., Hewitt SM; Laboratory of Pathology Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Ambs S; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Lockett SJ; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Wink DA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.

Publikováno v: Cancer research communications [Cancer Res Commun] 2024 Oct 01; Vol. 4 (10), pp. 2766-2782.

Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors.

Autor: Ridnour LA; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Cheng RY; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Kedei N; Collaborative Protein Technology Resource (CPTR) Nanoscale Protein Analysis, OSTR, CCR, NCI, NIH, Bethesda, Maryland, USA., Somasundaram V; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Bhattacharyya DD; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Basudhar D; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Wink AL; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, and., Walke AJ; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, and., Kim C; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, and., Heinz WF; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, and., Edmondson EF; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, Maryland, USA., Butcher DO; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, Maryland, USA., Warner AC; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, Maryland, USA., Dorsey TH; Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland, USA., Pore M; Imaging Mass Cytometry Frederick National Laboratory for Cancer Research, and., Kinders RJ; Office of the Director, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland, USA., Lipkowitz S; Women's Malignancy Branch CCR, NCI, NIH, Bethesda, Maryland, USA., Bryant RJ; Department of Urology, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom., Rittscher J; Institute of Biomedical Engineering, Big Data Institute, Ludwig Oxford Branch, University of Oxford, Oxford, United Kingdom., Wong ST; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas, USA., Hewitt SM; Laboratory of Pathology CCR, NCI, NIH, Bethesda, Maryland, USA., Chang JC; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas, USA., Shalaby A; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Callagy GM; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Glynn SA; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Ambs S; Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland, USA., Anderson SK; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA.; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., McVicar DW; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Lockett SJ; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, and., Wink DA; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA.

Publikováno v: JCI insight [JCI Insight] 2024 May 21; Vol. 9 (12). Date of Electronic Publication: 2024 May 21.

Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patients.

Autor: Ridnour LA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD., Cheng RYS; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD., Heinz WF; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD., Pore M; Imaging Mass Cytometry Frederick National Laboratory for Cancer Research., Gonzalez AL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD., Femino EL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD., Moffat R; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD., Wink AL; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD., Imtiaz F; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD., Coutinho L; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD.; Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, SP, Brazil., Butcher D; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute., Edmondson EF; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute., Rangel MC; Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, SP, Brazil., Wong STC; Houston Methodist Weill Cornell Medical College, Houston TX., Lipkowitz S; Women's Malignancies Branch, CCR, NCI, NIH., Glynn S; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Vitek MP; (Mike Duke)., McVicar DW; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD., Li X; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA., Anderson SK; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD.; Basic Science Program, Frederick National Laboratory for Cancer Research., Paolocci N; Division of Cardiology, Department of Medicine, Johns Hopkins University, and Department of Biomedical Sciences, University of Padova, Italy.; Laboratory of Pathology CCR, NCI, NIH., Hewitt SM; Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD., Ambs S; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA., Billiar TR; Mary and Ron Neal Cancer Center, Houston Methodist Hospital and Weill Cornell Medicine, Houston, TX., Chang JC; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD.; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD.; Imaging Mass Cytometry Frederick National Laboratory for Cancer Research.; Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, SP, Brazil.; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute.; Houston Methodist Weill Cornell Medical College, Houston TX.; Women's Malignancies Branch, CCR, NCI, NIH.; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland.; (Mike Duke).; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA.; Basic Science Program, Frederick National Laboratory for Cancer Research.; Division of Cardiology, Department of Medicine, Johns Hopkins University, and Department of Biomedical Sciences, University of Padova, Italy.; Laboratory of Pathology CCR, NCI, NIH.; Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD.; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.; Mary and Ron Neal Cancer Center, Houston Methodist Hospital and Weill Cornell Medicine, Houston, TX., Lockett SJ; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research; Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, MD., Wink DA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 23. Date of Electronic Publication: 2023 Dec 23.

New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders.

Autor: Gouveia Júnior FS; Laboratory of Bioinorganic Chemistry, Department of Organic and Inorganic Chemistry, Federal University of Ceara, 60455-760, Fortaleza-CE, Brazil. eduardohss@dqoi.ufc.br., Silveira JAM; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, 60.430-275, Fortaleza-CE, Brazil.; Drug Research and Development Center (NPDM), Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil., Holanda TM; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, 60.430-275, Fortaleza-CE, Brazil.; Drug Research and Development Center (NPDM), Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil., Marinho AD; Drug Research and Development Center (NPDM), Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil., Ridnour LA; National Cancer Institute, Cancer and Inflammation Program, Frederick, Maryland 21702, USA., Wink DA; National Cancer Institute, Cancer and Inflammation Program, Frederick, Maryland 21702, USA., de Siqueira RJB; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, 60.430-275, Fortaleza-CE, Brazil., Monteiro HSA; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, 60.430-275, Fortaleza-CE, Brazil.; Drug Research and Development Center (NPDM), Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil., Sousa EHS; Laboratory of Bioinorganic Chemistry, Department of Organic and Inorganic Chemistry, Federal University of Ceara, 60455-760, Fortaleza-CE, Brazil. eduardohss@dqoi.ufc.br., Lopes LGF; Laboratory of Bioinorganic Chemistry, Department of Organic and Inorganic Chemistry, Federal University of Ceara, 60455-760, Fortaleza-CE, Brazil. eduardohss@dqoi.ufc.br.

Publikováno v: Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2023 Apr 25; Vol. 52 (16), pp. 5176-5191. Date of Electronic Publication: 2023 Apr 25.

Chronic Exposure to Nitric Oxide Induces P53 Mutations and Malignant-like Features in Human Breast Epithelial Cells.

Autor: Cheng RYS; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Burkett S; Molecular Cytogenetics Section, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Ambs S; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Moody T; Center for Cancer Training Office of Training and Education, National Cancer Institute, Bethesda, MD 20892, USA., Wink DA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Ridnour LA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

Publikováno v: Biomolecules [Biomolecules] 2023 Feb 07; Vol. 13 (2). Date of Electronic Publication: 2023 Feb 07.