A G358S mutation in the Plasmodium falciparum Na ⁺ pump PfATP4 confers clinically-relevant resistance to cipargamin.

Autor: Qiu D; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Pei JV; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Rosling JEO; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Thathy V; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Li D; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Xue Y; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Tanner JD; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Penington JS; Bioinformatic Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Aw YTV; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Aw JYH; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Xu G; Department of Molecular Microbiology & Immunology and Johns Hopkins Malaria Institute, Johns Hopkins School of Public Health, Baltimore, MD, 21205, USA., Tripathi AK; Department of Molecular Microbiology & Immunology and Johns Hopkins Malaria Institute, Johns Hopkins School of Public Health, Baltimore, MD, 21205, USA., Gnadig NF; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Yeo T; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Fairhurst KJ; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Stokes BH; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Murithi JM; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Kümpornsin K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Hasemer H; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Dennis ASM; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Ridgway MC; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Schmitt EK; Novartis Pharma AG, Novartis Campus, Basel, 4056, Switzerland., Straimer J; Novartis Institute for Tropical Diseases, Emeryville, CA, 94608, USA., Papenfuss AT; Bioinformatic Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3052, Australia., Lee MCS; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Corry B; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Sinnis P; Department of Molecular Microbiology & Immunology and Johns Hopkins Malaria Institute, Johns Hopkins School of Public Health, Baltimore, MD, 21205, USA., Fidock DA; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, 10032, USA., van Dooren GG; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Kirk K; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia., Lehane AM; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia. adele.lehane@anu.edu.au.

Publikováno v: Nature communications [Nat Commun] 2022 Sep 30; Vol. 13 (1), pp. 5746. Date of Electronic Publication: 2022 Sep 30.

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Simple supplementation of serum-free medium produces gametocytes of Plasmodium falciparum that transmit to mosquitoes.

Autor: Pradhan, Sabyasachi¹ (AUTHOR) sabyasachi.pradhan@glasgow.ac.uk, Ubiaru, Prince Chigozirim¹ (AUTHOR), Ranford-Cartwright, Lisa¹ (AUTHOR) Lisa.ranford-cartwright@glasgow.ac.uk

Publikováno v: Malaria Journal. 9/10/2024, Vol. 23 Issue 1, p1-8. 8p.

Distinct adaptations of a gametocyte ABC transporter to murine and human Plasmodium parasites and its incompatibility in cross-species complementation.

Autor: Kenthirapalan S; Parasitology Unit, Max Planck Institute for Infection Biology, 10117 Berlin, Germany., Tran PN; Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 2601, Australia., Kooij TWA; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands., Ridgway MC; Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 2601, Australia., Rauch M; Parasitology Unit, Max Planck Institute for Infection Biology, 10117 Berlin, Germany; Dept. of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany., Brown SHJ; School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia., Mitchell TW; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia; School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia., Matuschewski K; Parasitology Unit, Max Planck Institute for Infection Biology, 10117 Berlin, Germany; Dept. of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany. Electronic address: kai.matuschewski@hu-berlin.de., Maier AG; Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 2601, Australia. Electronic address: alex.maier@anu.edu.au.

Publikováno v: International journal for parasitology [Int J Parasitol] 2020 Jun; Vol. 50 (6-7), pp. 511-522. Date of Electronic Publication: 2020 May 21.

Biochemical characterization and chemical inhibition of PfATP4-associated Na ⁺ -ATPase activity in Plasmodium falciparum membranes.

Autor: Rosling JEO; From the Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia., Ridgway MC; From the Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia., Summers RL; From the Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia., Kirk K; From the Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia kiaran.kirk@anu.edu.au., Lehane AM; From the Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia adele.lehane@anu.edu.au.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Aug 24; Vol. 293 (34), pp. 13327-13337. Date of Electronic Publication: 2018 Jul 09.