Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rida Mourtada"'
Autor:
Rida Mourtada, Sonali B Fonseca, Simon P Wisnovsky, Mark P Pereira, Xiaoming Wang, Rose Hurren, Jeremy Parfitt, Lesley Larsen, Robin A J Smith, Michael P Murphy, Aaron D Schimmer, Shana O Kelley
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60253 (2013)
We have successfully delivered a reactive alkylating agent, chlorambucil (Cbl), to the mitochondria of mammalian cells. Here, we characterize the mechanism of cell death for mitochondria-targeted chlorambucil (mt-Cbl) in vitro and assess its efficacy
Externí odkaz:
https://doaj.org/article/e03cf7fdc1eb452ebcf2372fb72dfd81
Autor:
Loren D. Walensky, Jamie A. Moroco, Henry D. Herce, Thomas E. Wales, John R. Engen, Daniel J. Yin, Rida Mourtada
Publikováno v:
Nature biotechnology
The clinical translation of cationic α-helical antimicrobial peptides (AMPs) has been hindered by structural instability, proteolytic degradation and in vivo toxicity from nonspecific membrane lysis. Although analyses of hydrophobic content and char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c5095d57c10147ac60faf526a1dc63
https://doi.org/10.1038/s41587-019-0222-z
https://doi.org/10.1038/s41587-019-0222-z
Autor:
Joel C. Bucci, Loren D. Walensky, Lixin Fan, Yael Ben-Nun, Danny Cohen, Steven P. Gygi, Liron David, Catherine E. Newman, Scott B. Hansen, Noah B. Bloch, Edward P. Harvey, Zachary J. Hauseman, John R. Engen, Rida Mourtada, Thomas E. Wales, Julian Mintseris, Devin K. Schweppe, Hao Wu, Henry D. Herce
Publikováno v:
Mol Cell
BAX is a pro-apoptotic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial outer membrane. How BAX monomers assemble into a higher-order conformation, and the structural determinants essential t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b5ff1b6aed8923f699e0b2bd0b9858
https://doi.org/10.1016/j.molcel.2020.05.029
https://doi.org/10.1016/j.molcel.2020.05.029
Publikováno v:
Oncogene
Hydrocarbon-stapled peptides that display key residues of the p53 transactivation domain have emerged as bona fide clinical candidates for reactivating the tumor suppression function of p53 in cancer by dual targeting of the negative regulators HDM2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ffdedd9096ae7e072db6b2ec4a5a94
https://pubmed.ncbi.nlm.nih.gov/27721413
https://pubmed.ncbi.nlm.nih.gov/27721413
Autor:
Rida Mourtada, Christopher P. Mill, Loren D. Walensky, Silvia Escudero, Emily B. Crawford, Susan Lee, Gregory H. Bird, Joseph T. Opferman, James Luccarelli, Marcia C. Haigis, Thomas E. Wales, Elma Zaganjor, Jiahao Chen, Ulrich Steidl, Ann M. Morgan, John R. Engen
Publikováno v:
Molecular Cell. 69:729-743.e7
Summary MCL-1 is a BCL-2 family protein implicated in the development and chemoresistance of human cancer. Unlike its anti-apoptotic homologs, Mcl-1 deletion has profound physiologic consequences, indicative of a broader role in homeostasis. We repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35f45dd683faa9c81629b1d5695afba
https://doi.org/10.1016/j.molcel.2018.02.005
https://doi.org/10.1016/j.molcel.2018.02.005
Publikováno v:
Biophysical Journal. 110:415a-416a
Antimicrobial peptides (AMPs) are a novel class of antibiotics comprised of short peptide sequences made up of 5 to 50 amino acids. Of particular interest are α-helical AMPs that kill bacteria through either membrane lysis or translocation and bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b867ad3620076cd39312476bd944c485
https://doi.org/10.1016/j.bpj.2015.11.2247
https://doi.org/10.1016/j.bpj.2015.11.2247
Autor:
Nasser Qaddoumi, Ayman H. El-Hag, Rida Mourtada, AbdelRahim Huwair, Ahmad Nimer, Esam Al Murawwi, Kamal AlMazam, Mohammed Hirzallah
Publikováno v:
2013 3rd International Conference on Electric Power and Energy Conversion Systems.
In this paper the possibility to use an RF antenna for both partial discharge (PD) detection and transformer oil quality monitoring is investigated. First, several RF antenna designs such as the dipole, axial helix and circular loop, have been compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a99c2edca332965377efd561dff5c27
https://doi.org/10.1109/epecs.2013.6713079
https://doi.org/10.1109/epecs.2013.6713079
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 17(44)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63bb2564796cc8234a9ffe71e672dddd
https://pubmed.ncbi.nlm.nih.gov/21932287
https://pubmed.ncbi.nlm.nih.gov/21932287
Publikováno v:
Pharmaceutical research. 28(11)
To create a new class of mitochondria-penetrating peptides (MPPs) that would facilitate drug delivery into the organelle through the inclusion of delocalized lipophilic cations (DLCs) in the peptide sequence.We synthesized two novel amino acids featu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f16cb185c4858eb3fabf672bff60a37
https://pubmed.ncbi.nlm.nih.gov/21833796
https://pubmed.ncbi.nlm.nih.gov/21833796
Autor:
Sonali B. Fonseca, Rose Hurren, Mark P. Pereira, Kristin L. Horton, Shana O. Kelley, Marcela Gronda, Rida Mourtada, Aaron D. Schimmer, Mark D. Minden
Publikováno v:
Chemistrybiology. 18(4)
SummaryThe difficulty of accessing the mitochondrial matrix has limited the targeting of therapeutics to this organelle. Here, we report, to our knowledge, the first successful delivery of an active DNA alkylating agent—chlorambucil—to mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2dd9a130a800170834ac4e69f3a27a
https://pubmed.ncbi.nlm.nih.gov/21513881
https://pubmed.ncbi.nlm.nih.gov/21513881