Synthesis of (Arylamido)pyrrolidinone Libraries through Ritter-Type Cascade Reactions of Dihydroxylactams

Autor: Martin Ohsten Rasmussen, Mads Hartvig Clausen, Karine Bonnet, Peng Wu, Thomas E. Nielsen, Michael Åxman Petersen, Rico Petersen

Publikováno v: European Journal of Organic Chemistry. 2015:5633-5639

The Ritter-type reaction of arylnitriles and N-acyliminium ions generated in situ from dihydroxy-γ-lactams gave tetrahydropyrrolo[2,3-d]oxazol-5-ones in excellent yields. A subsequent acidic hydrolysis in EtOH/H2O/TFA (trifluoroacetic acid) yielded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a59988ddc47dad70dd808be4e672e021
https://doi.org/10.1002/ejoc.201500712

A broad range quorum sensing inhibitor working through sRNA inhibition

Autor: Joana A. Moscoso, Paal Skytt Andersen, Morten Rybtke, Tim Tolker-Nielsen, Tim Holm Jakobsen, Rico Petersen, Alain Filloux, Thomas E. Nielsen, Rebecca Munk Vejborg, Frederik Lorenzen, Michael Givskov, Anders N. Warming, Hanne Ingmer, Marc Stegger, Jens Bo Andersen

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Jakobsen, T H, Warming, A N, Vejborg, R M, Moscoso, J A, Stegger, M, Lorenzen, F, Rybtke, M, Andersen, J B, Petersen, R, Andersen, P S, Nielsen, T E, Tolker-Nielsen, T, Filloux, A, Ingmer, H & Givskov, M 2017, ' A broad range quorum sensing inhibitor working through sRNA inhibition ', Scientific Reports, vol. 7, no. 1, 9857 . https://doi.org/10.1038/s41598-017-09886-8
Jakobsen, T H, Warming, A N, Vejborg, R M, Moscoso, J A, Stegger, M, Lorenzen, F, Rybtke, M T, Andersen, J B, Petersen, R, Andersen, P S, Nielsen, T E, Tolker-Nielsen, T, Filloux, A, Ingmer, H & Givskov, M 2017, ' A broad range quorum sensing inhibitor working through sRNA inhibition ', Scientific Reports, vol. 7, no. 1, pp. 9857 . https://doi.org/10.1038/s41598-017-09886-8
Scientific Reports

For the last decade, chemical control of bacterial virulence has received considerable attention. Ajoene, a sulfur-rich molecule from garlic has been shown to reduce expression of key quorum sensing regulated virulence factors in the opportunistic pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d18e7bfa1f73a93a976304d23c0d3e
https://doi.org/10.1038/s41598-017-09886-8

Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions

Autor: Michael Åxman Petersen, Mads Hartvig Clausen, Mette Ishoey, Thomas E. Nielsen, Peng Wu, Rico Petersen

Publikováno v: Ishoey, M, Petersen, R G, Petersen, M A, Wu, P, Clausen, M H & Nielsen, T E 2017, ' Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions ', Chemical Communications, vol. 53, no. 68, pp. 9410-9413 . https://doi.org/10.1039/c7cc02948a
Ishøy, M, Petersen, R, Petersen, M Å, Wu, P, Clausen, M H & Nielsen, T E 2017, ' Diastereoselective Synthesis of Novel Heterocyclic Scaffolds through Tandem Petasis 3-Component/Intramolecular Diels-Alder and ROM-RCM Reactions ', Chemical Communications, vol. 53, no. 68, pp. 9410-9413 . https://doi.org/10.1039/C7CC02948A

A high-yielding, stereoselective and extraordinarily complexity generatingPetasis 3-component/intramolecular Diels-Alderreaction has been developed. In combination with ROM-RCM, rapid access to complex sp3-rich heterocyclic scaffolds amenableto subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735d704124ce5f57cfc0f6b12a4bd0a9
https://curis.ku.dk/ws/files/202200725/Diastereoselective_synthesis_of_novel_heterocyclic_scaffolds_through_tandem_Petasis_3_component_intramolecular_Diels_Alder_and_ROM_RCM_reactions_2017_accepted.pdf

Synthesis of Oxacyclic Scaffolds via Dual Ruthenium Hydride/Brønsted Acid-Catalyzed Isomerization/Cyclization of Allylic Ethers

Autor: David Tanner, Rico Petersen, Erhad Ascic, Thomas E. Nielsen, Mette Reimert Hansen, Ragnhild Gaard Ohm, Casper Lykke Hansen, Daniel Esmarch Madsen

Publikováno v: Chemistry - A European Journal. 20:3297-3300

A ruthenium hydride/Brønsted acid-catalyzed tandem sequence is reported for the synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]indoles (THPIs) and related oxacyclic scaffolds. The process was designed on the premise that readily available allylic ether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce469cd1d4a73ff2708088b4bb91a874
https://doi.org/10.1002/chem.201304270

Synthesis of Constrained Peptidomimetics via the Pictet-Spengler Reaction

Autor: Rico Petersen, Vitaly V. Komnatnyy, Thomas E. Nielsen

Publikováno v: Topics in Heterocyclic Chemistry ISBN: 9783319491233

Peptidomimetics offers a solution to the poor pharmacokinetic properties displayed by natural peptides, by providing pharmaceutically useful chemical structures with the ability to mimic the endogenous polyamide structure. This chapter gives an overv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82c196fcf2f07b49311b35d1e459631f
https://doi.org/10.1007/7081_2015_190