Výsledky vyhledávání - "Ricky W. Johnstone"

Akademický článek

PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity

Autor: Tirta M. Djajawi, Lizzy Pijpers, Akash Srivaths, David Chisanga, Kok Fei Chan, Simon J. Hogg, Liam Neil, Sarahi Mendoza Rivera, Nenad Bartonicek, Sarah L. Ellis, Terry C.C. Lim Kam Sian, Pouya Faridi, Yang Liao, Bhupinder Pal, Andreas Behren, Wei Shi, Stephin J. Vervoort, Ricky W. Johnstone, Conor J. Kearney

Publikováno v: Cell Reports, Vol 43, Iss 3, Pp 113831- (2024)

Summary: Cancer immunotherapies have demonstrated remarkable success; however, the majority of patients do not respond or develop resistance. Here, we conduct epigenetic gene-targeted CRISPR-Cas9 screens to identify epigenomic factors that limit CD8+

Externí odkaz: https://doaj.org/article/f34b9312d8234fce939c7254165dac3d

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Akademický článek

A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been developed for targeting the A2AR receptor. Understanding of the mechanism by which A2AR is regulated

Externí odkaz: https://doaj.org/article/b9c76314c12142099494e8759d06a025

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Akademický článek

CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

Publikováno v: Cell Reports, Vol 42, Iss 8, Pp 113014- (2023)

Summary: CXCL9 expression is a strong predictor of response to immune checkpoint blockade therapy. Accordingly, we sought to develop therapeutic strategies to enhance the expression of CXCL9 and augment antitumor immunity. To perform whole-genome CRI

Externí odkaz: https://doaj.org/article/36f8c10bf54b436e8b3737f736a4464b

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Akademický článek

Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models induces the expression of EGR2, which drives and stabilises exhausted cell epige

Externí odkaz: https://doaj.org/article/835402bfc1a5448994d0c742c77cfabd

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Akademický článek

The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Rearrangements of the Mixed Lineage Leukemia (MLL/KMT2A) gene are present in approximately 10% of acute leukemias and characteristically define disease with poor outcome. Driven by the unmet need to develop better therapies for KMT2A-rearranged leuke

Externí odkaz: https://doaj.org/article/030ef39db2a746f68cb7bcf2cf823422

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Akademický článek

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

Autor: Madison J. Kelly, Joan So, Amy J. Rogers, Gareth Gregory, Jason Li, Magnus Zethoven, Micah D. Gearhart, Vivian J. Bardwell, Ricky W. Johnstone, Stephin J. Vervoort, Lev M. Kats

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

BCL6 corepressor (BCOR) is recurrently mutated in acute myeloid leukaemia and myelodysplastic syndrome. Here, the authors use mouse models to show the mechanism of how inactivation of BCOR in haematopoietic stem cells contributes to the development o

Externí odkaz: https://doaj.org/article/a2e6698ad2f4471982b9c6935cb918b2

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