Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ricky M Trigg"'
Autor:
Perla Pucci, Liam C. Lee, Miaojun Han, Jamie D. Matthews, Leila Jahangiri, Michaela Schlederer, Eleanor Manners, Annabel Sorby-Adams, Joshua Kaggie, Ricky M. Trigg, Christopher Steel, Lucy Hare, Emily R. James, Nina Prokoph, Stephen P. Ducray, Olaf Merkel, Firkret Rifatbegovic, Ji Luo, Sabine Taschner-Mandl, Lukas Kenner, G. A. Amos Burke, Suzanne D. Turner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeting Anaplastic lymphoma kinase (ALK) is a promising therapeutic strategy for aberrant ALK-expressing malignancies including neuroblastoma, but resistance to ALK tyrosine kinase inhibitors (ALK TKI) is a distinct possibility necessitati
Externí odkaz:
https://doaj.org/article/12cef060f54047bf95b2dad4e211f0d7
Autor:
Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Leila Jahangiri, C. Patrick Reynolds, G. A. Amos Burke, Nicola A. Probst, Miaojun Han, Jamie D. Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D. Turner
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Anaplastic lymphoma kinase (ALK) inhibitors are currently being considered in neuroblastoma (NB), but its acquired resistance is reported in non-small cell lung cancers. Here, the authors have found PIM1 overexpression decreases sensitivity to ALK in
Externí odkaz:
https://doaj.org/article/f2be0a65707b41b5b2ef0367cf79b3cb
Autor:
Leila Jahangiri, Loukia Tsaprouni, Ricky M. Trigg, John A. Williams, Georgios V. Gkoutos, Suzanne D. Turner, Joao Pereira
Publikováno v:
Open Biology, Vol 10, Iss 7 (2020)
Gene expression programmes driving cell identity are established by tightly regulated transcription factors that auto- and cross-regulate in a feed-forward manner, forming core regulatory circuitries (CRCs). CRC transcription factors create and engag
Externí odkaz:
https://doaj.org/article/cc39a8f1b56d47349cee7cbe55ad6576
Autor:
Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M. Trigg, John A. Williams, Joao Pereira, Megan L. Cavanagh, Suzanne D. Turner, Georgios V. Gkoutos, Loukia Tsaprouni
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8527 (2021)
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is im
Externí odkaz:
https://doaj.org/article/316377926a4a442eb0b305705449aaeb
Publikováno v:
Open Biology, Vol 9, Iss 5 (2019)
Molecular analysis of nucleic acid and protein biomarkers is becoming increasingly common in paediatric oncology for diagnosis, risk stratification and molecularly targeted therapeutics. However, many current and emerging biomarkers are based on anal
Externí odkaz:
https://doaj.org/article/19238e593b9b4af889920ed4fa849336
Autor:
Callum P. Rakhit, Ricky M. Trigg, John Le Quesne, Michael Kelly, Jacqueline A. Shaw, Catrin Pritchard, L. Miguel Martins
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 2 (2019)
Lung cancer is the leading cause of cancer-related death. Two-thirds of cases are diagnosed at an advanced stage that is refractory to curative treatment. Therefore, strategies for the early detection of lung cancer are urgently sought. Total circula
Externí odkaz:
https://doaj.org/article/55683664eb594c6d91fe5983f3330898
Autor:
Petra Kodajova, Sonia Sánchez Martínez, Nicola A. Probst, Liam C. Lee, Ines Garces de los Fayos Alonso, Miaojun Han, Sandra Högler, Joaquín Pastor, G. A. Amos Burke, C. Patrick Reynolds, Hong Kai Lim, Eleanor Manners, Carmen Blanco-Aparicio, Leila Jahangiri, Jamie D. Matthews, Ji Luo, Suzanne D. Turner, Nina Prokoph, Simone Tangermann, Lukas Kenner, Olaf Merkel, Ricky M Trigg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)
Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To proactively identify resistance mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced51d17bd4e3809b2cf33e72bf7a838
http://link.springer.com/article/10.1038/s41467-019-13315-x
http://link.springer.com/article/10.1038/s41467-019-13315-x
Autor:
Ricky M Trigg, João D. Pereira, Georgios V. Gkoutos, Perla Pucci, John A. Williams, Suzanne D. Turner, Loukia Tsaprouni, Leila Jahangiri, Megan L Cavanagh, Tala Ishola
Publikováno v:
Cancers, Vol 13, Iss 1239, p 1239 (2021)
Cancers
Cancers
Simple Summary Cancer stem cells (CSCs) represent a distinct cancer subpopulation that can influence the tumour microenvironment, in addition to cancer progression and relapse. A multitude of factors including CSC properties, long noncoding RNAs (lnc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a5972cd0993a3863914f050da20661
https://www.mdpi.com/2072-6694/13/6/1239
https://www.mdpi.com/2072-6694/13/6/1239
Autor:
Loukia Tsaprouni, Georgios V. Gkoutos, John A. Williams, Suzanne D. Turner, João D. Pereira, Ricky M Trigg, Leila Jahangiri
Publikováno v:
Open Biology, Vol 10, Iss 7 (2020)
Open Biology
Open Biology
Gene expression programmes driving cell identity are established by tightly regulated transcription factors that auto- and cross-regulate in a feed-forward manner, forming core regulatory circuitries (CRCs). CRC transcription factors create and engag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6866d09399f8d3510c69841e010848fc
https://doi.org/10.1098/rsob.200121
https://doi.org/10.1098/rsob.200121
