Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Ricky D. Edmondson"'
Autor:
Jie Li, Phillip M. Galbo, Weida Gong, Aaron J. Storey, Yi-Hsuan Tsai, Xufen Yu, Jeong Hyun Ahn, Yiran Guo, Samuel G. Mackintosh, Ricky D. Edmondson, Stephanie D. Byrum, Jason E. Farrar, Shenghui He, Ling Cai, Jian Jin, Alan J. Tackett, Deyou Zheng, Gang Greg Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The fusion gene ZMYND11-MBTD1 (ZM) is present in a subgroup of patients with acute myeloid leukaemia (AML). Here, the authors show that ZM expression induces AML in a murine model though activating the NuA4/TIP60 histone acetyltransferase complex.
Externí odkaz:
https://doaj.org/article/cdcc2ab94850477c835abe99c9bfa857
Autor:
Bradley D. Shields, Fade Mahmoud, Erin M. Taylor, Stephanie D. Byrum, Deepanwita Sengupta, Brian Koss, Giulia Baldini, Seth Ransom, Kyle Cline, Samuel G. Mackintosh, Ricky D. Edmondson, Sara Shalin, Alan J. Tackett
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Modulation of the immune system can produce anti-tumor responses in various cancer types, including melanoma. Recently, immune checkpoint inhibitors (ICI), in single agent and combination regimens, have produced durable and long-lasting clin
Externí odkaz:
https://doaj.org/article/cef50263e016446d94ea892a09c098c1
Autor:
Deyou Zheng, Samuel G. Mackintosh, Ling Cai, Daniel P. Keeley, Hidetaka Uryu, Shuai Zhao, Douglas H. Phanstiel, Alan J. Tackett, Gang Greg Wang, Davis Eric, Ivana Y Quiroga, Aaron J. Storey, Stephanie D. Byrum, Ricky D. Edmondson, Yi-Hsuan Tsai, Jeong Hyun Ahn, Jie Li, Timothy A. Daugird, Wesley R. Legant
Publikováno v:
Nature. 595:591-595
The development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regions (IDRs). In human haematological malignancies, recurrent chromosomal translocation of nucleoporin (NUP98 or NUP214
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3db78f718ab000c0b01e73ad90e4cc3c
https://doi.org/10.1038/s41586-021-03662-5
https://doi.org/10.1038/s41586-021-03662-5
Autor:
Ling Cai, Aaron J. Storey, Samuel G. Mackintosh, Weida Gong, Arum Kim, Alan J. Tackett, Stephanie D. Byrum, Ricky D. Edmondson, Yiran Guo, Yi-Hsuan Tsai, Huitao Fan, Haitao Li, Gang Greg Wang
Publikováno v:
Nucleic Acids Research
Trimethylation of histone H3 lysine 27 (H3K27me3) is important for gene silencing and imprinting, (epi)genome organization and organismal development. In a prevalent model, the functional readout of H3K27me3 in mammalian cells is achieved through the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3f7d9ca806a0db68e096cf1386c89a
http://europepmc.org/articles/PMC8096256
http://europepmc.org/articles/PMC8096256
Autor:
Kanishka Manna, Prashanthi Dharanipragada, Duah Alkam, Nathan L. Avaritt, Charity L. Washam, Tung-chin Chiang, Michael S Robeson, Ricky D. Edmondson, Samuel G. Mackintosh, Zhentao Yang, Yan Wang, Shirley H. Lomeli, Gatien Moriceau, Roger S. Lo, Alan J. Tackett, Stephanie D. Byrum
Therapeutic approaches to treat melanoma include small molecule drugs that target activating protein mutations in pro-growth signaling pathways like the MAPK pathway. While beneficial to the approximately 50% of patients with activatingBRAFV600mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b31ecbe4a7f506bf06d484cfc388b48
https://doi.org/10.17504/protocols.io.b68erhte
https://doi.org/10.17504/protocols.io.b68erhte
Autor:
Timothy Aballo, Theresa Mensah, Samuel G. Mackintosh, Xien Yu Chua, Ricky D. Edmondson, Arthur R. Salomon
Publikováno v:
Mol Cell Proteomics
Dynamic tyrosine phosphorylation is fundamental to a myriad of cellular processes. However, the inherently low abundance of tyrosine phosphorylation in the proteome and the inefficient enrichment of phosphotyrosine(pTyr)-containing peptides has led t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda9128a0247c902a3229fbe2b6c0a58
https://doi.org/10.1074/mcp.tir119.001865
https://doi.org/10.1074/mcp.tir119.001865
Autor:
Kanishka Manna, Prashanthi Dharanipragada, Duah Alkam, Nathan L. Avaritt, Charity L. Washam, Michael S. Robeson, Ricky D. Edmondson, Samuel G. Mackintosh, Zhentao Yang, Yan Wang, Shirley H. Lomeli, Gatien Moriceau, Stephanie D. Byrum, Roger S. Lo, Alan J. Tackett
Therapeutic approaches to treat melanoma include small molecule drugs that target activating protein mutations in pro-growth signaling pathways like the MAPK pathway. While beneficial to the approximately 50% of patients with activating BRAFV600 muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c901c8d9ebf37fbe61741e5a30391d
https://doi.org/10.1101/2022.02.15.480454
https://doi.org/10.1101/2022.02.15.480454
Autor:
Weida Gong, Stephanie D. Byrum, Phillip M. Galbo, Jie Li, Ling Cai, Alan J. Tackett, Aaron J. Storey, Samuel G. Mackintosh, Xufen Yu, Yi-Hsuan Tsai, Jeong Hyun Ahn, Shenghui He, Yiran Guo, Jian Jin, Ricky D. Edmondson, Jason E. Farrar, Deyou Zheng, Gang Greg Wang
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Recurring chromosomal translocation t(10;17)(p15;q21) present in a subset of human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed ZMYND11-MBTD1 (ZM); however, its function remains undetermined. Here, we show that ZM conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb999bbfc378015f10f1f401606351e
http://europepmc.org/articles/PMC7886901
http://europepmc.org/articles/PMC7886901
Autor:
James A Stahl, Shweta S Chavan, Jeffrey M Sifford, Veronica MacLeod, Daniel E Voth, Ricky D Edmondson, J Craig Forrest
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003583 (2013)
Lytic gammaherpesvirus (GHV) replication facilitates the establishment of lifelong latent infection, which places the infected host at risk for numerous cancers. As obligate intracellular parasites, GHVs must control and usurp cellular signaling path
Externí odkaz:
https://doaj.org/article/7ad478253cdf4b53877ee99992c6dea0
Autor:
Ling Cai, Stephanie D. Byrum, Chenxi Xu, Ricky D. Edmondson, Samuel G. Mackintosh, Young E. Whang, Gang Greg Wang, Weida Gong, Yuemei Xu, Phillip M. Galbo, Alan J. Tackett, Deyou Zheng, Aaron J. Storey, H. Shelton Earp, Yi-Hsuan Tsai, Jiaoti Huang, Joel S. Parker
Castration-resistant prostate cancer (CRPC) is a terminal disease, demanding a better understanding of its pathogenesis. Targeted therapy needs to be developed for CRPC due to its heterogeneity and resistance to current treatments. Here, through cist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66956ce5436b0129faaaf419edafc87b
https://doi.org/10.1101/2020.09.17.302596
https://doi.org/10.1101/2020.09.17.302596