Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Rickvinder, Besla"'
Autor:
Tharini Sivasubramaniyam, Jiaqi Yang, Henry S. Cheng, Alexandra Zyla, Angela Li, Rickvinder Besla, Idit Dotan, Xavier S. Revelo, Sally Yu Shi, Helen Le, Stephanie A. Schroer, David W. Dodington, Yoo Jin Park, Min Jeong Kim, Daniella Febbraro, Isabelle Ruel, Jacques Genest, Raymond H. Kim, Tak W. Mak, Daniel A. Winer, Clinton S. Robbins, Minna Woo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Inflammation is a key contributor to atherosclerosis with macrophages playing a pivotal role through the induction of oxidative stress and cytokine/chemokine secretion. DJ1, an anti-oxidant protein, has shown to paradoxically protect against
Externí odkaz:
https://doaj.org/article/dd1b0c94e3934c83829b8e94c00d30fc
Autor:
Harsh R. Desai, Tharini Sivasubramaniyam, Xavier S. Revelo, Stephanie A. Schroer, Cynthia T. Luk, Prashanth R. Rikkala, Adam H. Metherel, David W. Dodington, Yoo Jin Park, Min Jeong Kim, Joshua A. Rapps, Rickvinder Besla, Clinton S. Robbins, Kay-Uwe Wagner, Richard P. Bazinet, Daniel A. Winer, Minna Woo
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract During obesity, macrophages can infiltrate metabolic tissues, and contribute to chronic low-grade inflammation, and mediate insulin resistance and diabetes. Recent studies have elucidated the metabolic role of JAK2, a key mediator downstream
Externí odkaz:
https://doaj.org/article/b77b851e7bc64e208ba3be8fd1060be7
Autor:
Eric A. Shikatani, Rickvinder Besla, Sherine Ensan, Aditi Upadhye, Nadiya Khyzha, Angela Li, Takuo Emoto, Felix Chiu, Norbert Degousee, Joshua M. Moreau, Heather M. Perry, Danya Thayaparan, Henry S. Cheng, Shaun Pacheco, David Smyth, Hossein Noyan, Caleb C.J. Zavitz, Carla M.T. Bauer, Ingo Hilgendorf, Peter Libby, Filip K. Swirski, Jennifer L. Gommerman, Jason E. Fish, Martin R. Stampfli, Myron I. Cybulsky, Barry B. Rubin, Christopher J. Paige, Timothy P. Bender, Coleen A. McNamara, Mansoor Husain, Clinton S. Robbins
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2304-2312.e6 (2019)
Summary: Mechanisms that govern transcriptional regulation of inflammation in atherosclerosis remain largely unknown. Here, we identify the nuclear transcription factor c-Myb as an important mediator of atherosclerotic disease in mice. Atherosclerosi
Externí odkaz:
https://doaj.org/article/739dd39d1f244a6f8144a50e8b09c4c0
Autor:
Shaun Pacheco, Thomas F. Lindsay, Yonghong Chen, Antigona Ulndreaj, Angela Li, Rickvinder Besla, John S Byrne, Myron I. Cybulsky, Marwan G Althagafi, Clinton S. Robbins
Publikováno v:
Clinical Science. 135:1295-1309
Objective: Aortic macrophage accumulation is characteristic of the pathogenesis of abdominal aortic aneurysm (AAA) but the mechanisms of macrophage accumulation and their phenotype are poorly understood. Lymphatic vessel endothelial receptor-1 (Lyve-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae7807440bfb0c78e149e258894c691
https://doi.org/10.1042/cs20200963
https://doi.org/10.1042/cs20200963
Autor:
Filio Billia, Felix Chiu, Craig A. Simmons, Rickvinder Besla, Abdul Momen, Danny D. Dinh, Clinton S. Robbins, Luke S. Dingwell, Scott P. Heximer, Eric A. Shikatani, Rohan John, Jennifer L. Gommerman, Mansoor Husain, Talat Afroze, James W. Scholey, Steffen-Sebastian Bolz, Hangjun Zhang, Michelle B. Chen, Andrew S. Levy
Publikováno v:
Hypertension. 73:561-570
The proto-oncogene c-myb (and corresponding nuclear transcription factor, c-Myb) regulates the proliferation and differentiation of hematologic and vascular smooth muscle cells; however, the role of c-Myb in blood pressure regulation is unknown. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62636bb8b69a771e74c0caaa20b42a0
https://doi.org/10.1161/hypertensionaha.118.11828
https://doi.org/10.1161/hypertensionaha.118.11828
Autor:
Yoo Jin Park, Minna Woo, David W. Dodington, Helen Le, Angela Li, Stephanie A. Schroer, Xavier S. Revelo, Alexandra Zyla, Jacques Genest, Min Jeong Kim, Daniella Febbraro, Tak W. Mak, Rickvinder Besla, Isabelle Ruel, Daniel A. Winer, Idit Dotan, Henry S. Cheng, Raymond H. Kim, Clinton S. Robbins, Jiaqi Yang, Tharini Sivasubramaniyam, Sally Yu Shi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Inflammation is a key contributor to atherosclerosis with macrophages playing a pivotal role through the induction of oxidative stress and cytokine/chemokine secretion. DJ1, an anti-oxidant protein, has shown to paradoxically protect against chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991f38dc3b33dcf7c104e04688db6bde
http://europepmc.org/articles/PMC7907332
http://europepmc.org/articles/PMC7907332
Autor:
Ilyse Darwish, David Banner, Samira Mubareka, Hani Kim, Rickvinder Besla, David J Kelvin, Kevin C Kain, W Conrad Liles
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71761 (2013)
Severe influenza remains a major public health threat and is responsible for thousands of deaths annually. Increasing antiviral resistance and limited effectiveness of current therapies highlight the need for new approaches to influenza treatment. Ex
Externí odkaz:
https://doaj.org/article/9ae550f64dd6468a8b9117ca967295f0
Autor:
Myron I. Cybulsky, Xavier Clemente-Casares, Rickvinder Besla, Sarah A. Dick, Jinmiao Chen, Sara Nejat, Rysa Zaman, Jillian A. Macklin, Abdul Momen, Anthony Wong, Siyavash Hosseinzadeh, Laura Aronoff, Slava Epelman, Crystal Kantores, Marwan G. Althagafi, Florent Ginhoux, Kory J. Lavine, Babak Razani, Mansoor Husain, Clinton S. Robbins, Iulia Barbu
Publikováno v:
Nature immunology
Macrophages promote both injury and repair after myocardial infarction, but discriminating functions within mixed populations remains challenging. Here we used fate mapping, parabiosis and single-cell transcriptomics to demonstrate that at steady sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa50154c1df0e7800bb991f4815f21a
http://europepmc.org/articles/PMC6565365
http://europepmc.org/articles/PMC6565365
Autor:
Angela Li, Sarah K. Steinbach, Martha H Carruthers, Clinton S. Robbins, Mansoor Husain, Adam P. Johnston, Rickvinder Besla, Tao Wang
Publikováno v:
Stem Cells and Development. 27:888-897
Sca-1+ progenitor cells in the adult mouse aorta are known to generate vascular smooth muscle cells (VSMCs), but their embryological origins and temporal abundance are not known. Using tamoxifen-inducible Myf5-CreER mice, we demonstrate that Sca-1+ a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c8d4e8cc69995e206a013fa35937ac
https://doi.org/10.1089/scd.2018.0038
https://doi.org/10.1089/scd.2018.0038
Autor:
Michele Geoffrion, Nadiya Khyzha, Katey J. Rayner, Angela Li, Chantal M. Boulanger, My-Anh Nguyen, Myron I. Cybulsky, Andreas Schober, Lei Cai, Mansoor Husain, Eric A. Shikatani, Tong Li, Rickvinder Besla, Ryan E. Temel, Maliheh Nazari-Jahantigh, Henry S. Cheng, Clinton S. Robbins, Jason E. Fish, Zhiqi Chen, Adel Hammoutene, Sonya A. MacParland
Publikováno v:
Circulation Research. 121:354-367
Rationale: Inflammation is a key contributor to atherosclerosis. MicroRNA-146a (miR-146a) has been identified as a critical brake on proinflammatory nuclear factor κ light chain enhancer of activated B cells signaling in several cell types, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be7030121afd7044933204a0124939d
https://doi.org/10.1161/circresaha.116.310529
https://doi.org/10.1161/circresaha.116.310529