Small Extracellular Vesicle-Associated MiRNAs in Polarized Retinal Pigmented Epithelium.

Autor: Hernandez BJ; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, United States., Strain M; Duke Molecular Physiology Institute, Department of Medicine, Duke University, Durham, North Carolina, United States., Suarez MF; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, United States., Stamer WD; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, United States.; Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States., Ashley-Koch A; Duke Molecular Physiology Institute, Department of Medicine, Duke University, Durham, North Carolina, United States., Liu Y; Department of Cellular Biology and Anatomy, James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, Georgia, United States., Klingeborn M; McLaughlin Research Institute, Great Falls, Montana, United States.; Touro College of Osteopathic Medicine Montana, Great Falls, Montana, United States., Bowes Rickman C; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, United States.; Department of Cell Biology, Duke University, Durham, North Carolina, United States.

Publikováno v: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2024 Nov 04; Vol. 65 (13), pp. 57.

Aging and intraocular pressure homeostasis in mice.

Autor: Li G; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., van Batenburg-Sherwood J; Department of Bioengineering, Imperial College London, London, UK., Safa BN; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Fraticelli Guzmán NS; Department of Ophthalmology, Emory University, Atlanta, Georgia, USA.; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Wilson A; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Bahrani Fard MR; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Choy K; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA., de Ieso ML; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Cui JS; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Feola AJ; Department of Ophthalmology, Emory University, Atlanta, Georgia, USA.; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.; Center for Visual and Neurocognitive Rehabilitation, Atlanta Virginia Medical Center, Decatur, Georgia, USA., Weisz T; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Kuhn M; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Bowes Rickman C; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Farsiu S; Department of Ophthalmology, Duke University, Durham, North Carolina, USA.; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA., Ethier CR; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.; Department of Ophthalmology, Emory University, Atlanta, Georgia, USA., Stamer WD; Department of Ophthalmology, Duke University, Durham, North Carolina, USA.; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.

Publikováno v: Aging cell [Aging Cell] 2024 Jul; Vol. 23 (7), pp. e14160. Date of Electronic Publication: 2024 Apr 02.

Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2.

Autor: Yu C; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA., Lad EM; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA., Mathew R; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA., Shiraki N; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA., Littleton S; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.; Department of Immunology, Duke University, Durham, NC, USA., Chen Y; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Hou J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Schlepckow K; German Center for Neurodegenerative Diseases Munich , Munich, Germany., Degan S; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA., Chew L; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA., Amason J; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA., Kalnitsky J; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA., Bowes Rickman C; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.; Department of Cell Biology, Duke University, Durham, NC, USA., Proia AD; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.; Department of Pathology, Campbell University Jerry M. Wallace School of Osteopathic Medicine, Lillington, NC, USA., Colonna M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Haass C; German Center for Neurodegenerative Diseases Munich , Munich, Germany.; Chair of Metabolic Biochemistry, Faculty of Medicine, Biomedical Center, Ludwig-Maximilians-Universität München, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) , Munich, Germany., Saban DR; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.; Department of Immunology, Duke University, Durham, NC, USA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2024 Mar 04; Vol. 221 (3). Date of Electronic Publication: 2024 Jan 30.

Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation.

Autor: Liu Z; Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, USA., Sokratian A; Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, USA., Duda AM; Department of Chemistry, Duke University, Durham, NC, USA., Xu E; Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, USA., Stanhope C; Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, USA., Fu A; Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, USA., Strader S; Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, USA., Li H; Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, USA., Yuan Y; Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, USA., Bobay BG; Department of Chemistry, Duke University, Durham, NC, USA., Sipe J; Department of Civil and Environmental Engineering, Duke University, Durham, NC, USA., Bai K; Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, USA., Lundgaard I; Department of Experimental Medical Science, Lund University, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden., Liu N; Department of Experimental Medical Science, Lund University, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden., Hernandez B; Department of Ophthalmology and Cell Biology, Duke University, Durham, NC, USA., Bowes Rickman C; Department of Ophthalmology and Cell Biology, Duke University, Durham, NC, USA., Miller SE; Department of Pathology, Duke University, Durham, NC, USA., West AB; Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.

Publikováno v: Science advances [Sci Adv] 2023 Nov 15; Vol. 9 (46), pp. eadi8716. Date of Electronic Publication: 2023 Nov 17.

Polarized Desmosome and Hemidesmosome Shedding via Small Extracellular Vesicles is an Early Indicator of Outer Blood-Retina Barrier Dysfunction.

Autor: Hernandez BJ; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA., Skiba NP; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA., Plössl K; Institute of Human Genetics, University of Regensburg, 93053 Regensburg, Germany., Strain M; Duke Molecular Physiology Institute, Department of Medicine, Duke University, Durham, NC 27710, USA., Liu Y; Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA., Grigsby D; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA., Kelly U; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA., Cady MA; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA., Manocha V; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA., Maminishkis A; Ophthalmic Genetics and Visual Function Branch, Section on Epithelial and Retinal Physiology and Disease, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA., Watkins T; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA.; Current address: Office of Animal Welfare Assurance, Duke Animal Care and Use Program, Duke University, Durham, NC 27710, USA., Miller SS; Ophthalmic Genetics and Visual Function Branch, Section on Epithelial and Retinal Physiology and Disease, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA., Ashley-Koch A; Duke Molecular Physiology Institute, Department of Medicine, Duke University, Durham, NC 27710, USA., Stamer WD; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA.; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Weber BHF; Institute of Human Genetics, University of Regensburg, 93053 Regensburg, Germany.; Institute of Clinical Human Genetics, University Hospital Regensburg, 93053 Regensburg, Germany., Bowes Rickman C; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA.; Department of Cell Biology, Duke University, Durham, NC 27710, US., Klingeborn M; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA.; Current address: McLaughlin Research Institute, Great Falls, MT 59405, USA.

Publikováno v: Journal of extracellular biology [J Extracell Biol] 2023 Oct; Vol. 2 (10). Date of Electronic Publication: 2023 Oct 11.