Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation

Autor: Ward Heggermont, Stephane Heymans, Javier Díez, Marieke Rienks, Uwe Himmelreich, Jolanda van der Velden, Sophie Deckx, Rick van Leeuwen, Tom Dresselaers, Arantxa González, Anna-Pia Papageorgiou, Paolo Carai, Wies Lommen

Publikováno v: Deckx, S, Heggermont, W, Carai, P, Rienks, M, Dresselaers, T, Himmelreich, U, van Leeuwen, R, Lommen, W, van der Velden, J, Gonzalez, A, Diez, J, Papageorgiou, A P & Heymans, S 2018, ' Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation ', Matrix Biology, vol. 66, pp. 110-124 . https://doi.org/10.1016/j.matbio.2017.09.002
Matrix Biology, 66, 110-124. Elsevier
Matrix Biology, 66, 110-124. Elsevier Science

The small leucine-rich proteoglycan osteoglycin has been implicated in matrix homeostasis in different organs, including the ischemic heart. However, whether osteoglycin modulates cardiac hypertrophy, fibrosis or inflammation in hypertensive heart di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654d8c01171bd2491abb5cd4d2005860
https://doi.org/10.1016/j.matbio.2017.09.002

Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure

Autor: Kerstin Korn, Wouter J. A. Derks, Blanche Schroen, Rick van Leeuwen, Robin Verjans, Stephane Heymans, Marc van Bilsen, Birte Sönnichsen

Publikováno v: Scientific Reports, 9:6055. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports

Heart failure (HF) is the leading cause of death in the Western world. Pathophysiological processes underlying HF development, including cardiac hypertrophy, fibrosis and inflammation, are controlled by specific microRNAs (miRNAs). Whereas most studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e7158a6cda2bf6ae52ea42c6c82d6c
https://cris.maastrichtuniversity.nl/en/publications/41d08f83-1794-4fe1-906a-cb8c4e81d276

SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis

Autor: Bianca Hemmeryckx, Elizabeth A. V. Jones, Wouter Verhesen, Rick van Leeuwen, Jurgen W. G. E. van Teeffelen, Anna-Pia Papageorgiou, Marieke Rienks, Daniel M. Johnson, Stephane Heymans, Bart Eskens, Paolo Carai

Publikováno v: Matrix Biology, 74, 21-34. Elsevier Science
Rienks, M, Carai, P, van Teeffelen, J, Eskens, B, Verhesen, W, Hemmeryckx, B, Johnson, D M, van Leeuwen, R, Jones, E A, Heymans, S & Papageorgiou, A-P 2018, ' SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis ', Matrix Biology . https://doi.org/10.1016/j.matbio.2018.04.015

Myocardial damage as a consequence of cardiotropic viruses leads to a broad variety of clinical presentations and is still a complicated condition to diagnose and treat. Whereas the extracellular matrix protein Secreted Protein Acidic and Rich in Cys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fef81b912213b9938fbab5cc5ad381b
https://lirias.kuleuven.be/handle/123456789/631698

Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction

Autor: Ies Elzenaar, Rik Gijsbers, Paolo Carai, Alexander Nickel, Blanche Schroen, Sophie Deckx, Peter Carmeliet, Stephane Heymans, Annelies Quaegebeur, Yigal M. Pinto, Christoph Maack, Ann-Sophie Walravens, Anna-Pia Papageorgiou, Stefan Janssens, Chris Van den Haute, Sandra Schoors, Sergey Alekseev, Peter Pokreisz, Marc van Bilsen, Guy Eelen, Wouter Verhesen, Ward Heggermont, Stefan Vinckier, Rick van Leeuwen

Publikováno v: Circulation, 136(8), 747-761. Lippincott Williams and Wilkins
Circulation, 136(8), 747-761. LIPPINCOTT WILLIAMS & WILKINS

Background: Cardiovascular diseases remain the predominant cause of death worldwide, with the prevalence of heart failure continuing to increase. Despite increased knowledge of the metabolic alterations that occur in heart failure, novel therapies to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63abf95b3209b677c7f6dd748e0ac64
https://pure.amc.nl/en/publications/inhibition-of-microrna146a-and-overexpression-of-its-target-dihydrolipoyl-succinyltransferase-protect-against-pressure-overloadinduced-cardiac-hypertrophy-and-dysfunction(312a717b-87a3-4d43-aa23-b5944bee4ea8).html

MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure

Autor: Marc A. M. J. van Zandvoort, Melissa Swinnen, Geert C. van Almen, Casper Eurlings, Jack P.M. Cleutjens, Mark W.M. Schellings, Rick van Leeuwen, Wouter Verhesen, Blanche Schroen, Mathijs van de Vrie, Stephane Heymans

Publikováno v: Aging Cell. 10:769-779

To understand the process of cardiac aging, it is of crucial importance to gain insight into the age-related changes in gene expression in the senescent failing heart. Age-related cardiac remodeling is known to be accompanied by changes in extracellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5440270985b43ea7db7e26c670a4ba0a
https://doi.org/10.1111/j.1474-9726.2011.00714.x