Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rick W. Ransom"'
Autor:
J. Fred Hess, Kathryn L. Murphy, Mark G. Bock, Rick W. Ransom, Dai-Shi Su, Douglas J. Pettibone, Tsing-Bau Chen, R. S. L. Chang, Sookhee Ha, Pat J. Hey
Publikováno v:
Biochemistry. 45:14355-14361
We report the critical residues for the interaction of the kinins with human bradykinin receptor 1 (B1) using site-directed mutagenesis in conjunction with molecular modeling of the binding modes of the kinins in the homology model of the B1 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc55ace01757df410c1bda88fec544d
https://doi.org/10.1021/bi060673f
https://doi.org/10.1021/bi060673f
Autor:
J. Fred Hess, Michael A. Wallace, Rick W. Ransom, Douglas J. Pettibone, C. Meacham Harrell, Kathy L. Murphy, Matthew M. Zrada, Roger M. Freidinger, M. Kristine Markowitz, Bang-Lin Wan, Dai-Shi Su, Mark G. Bock, Dennis C. Dean, R. S. L. Chang, S. S. O'malley, Conrad E. Raab
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:6045-6048
We have developed an efficient and selective radioligand, the [35S]-radiolabeled dihydroquinoxalinone derivative, 4, for an ex vivo receptor occupancy assay in transgenic rats over-expressing the human bradykinin B1 receptor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd26b8e760658cf74db72a04fe61f73b
https://doi.org/10.1016/j.bmcl.2004.09.074
https://doi.org/10.1016/j.bmcl.2004.09.074
Autor:
J. Di Salvo, Rick W. Ransom, S. S. O'malley, R. S. L. Chang, Robert M. DiPardo, Mark G. Bock, Michael A. Patane, R. P. Price
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b19ecdbc30d16f04cb60dcc018e89460
https://doi.org/10.1002/chin.199902141
https://doi.org/10.1002/chin.199902141
Publikováno v:
Biochemical and Biophysical Research Communications. 184:260-268
A human BK-2 bradykinin receptor was cloned from the lung fibroblast cell line CCD-16Lu. The cDNA clone encodes a 364 amino acid protein that has the characteristics of a seven transmembrane domain G-protein coupled receptor. The predicted amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba40a5cea3c486d4e813e2aa4cebdd3
https://doi.org/10.1016/0006-291x(92)91187-u
https://doi.org/10.1016/0006-291x(92)91187-u
Autor:
Rick W. Ransom, Douglas J. Pettibone, Roger M. Freidinger, Jian Yu, Neville J. Anthony, Raymond S.L. Chang, Bang-Lin Wan, Dai-Shi Su, Thomayant Prueksaritanont, Mark G. Bock, Duane R. Reiss, S. S. O'malley, C. Meacham Harrell, Kathy L. Murphy, Cuyue Tang, John Jin Lim, Elizabeth Tinney
Publikováno v:
Journal of medicinal chemistry. 51(13)
Selective bradykinin (BK) B 1 receptor antagonists could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure activity relationships of the structurally novel HTS lead compound 1 provided potent hBK B 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656e77594201ffecbc747fd7d596257e
https://pubmed.ncbi.nlm.nih.gov/18553956
https://pubmed.ncbi.nlm.nih.gov/18553956
Autor:
Mark G. Bock, Duane R. Reiss, Douglas J. Pettibone, Thomayant Prueksaritanont, M. Kristine Markowitz, Roger M. Freidinger, Cuyue Tang, S. S. O'malley, John Jin Lim, Kathy L. Murphy, Rick W. Ransom, Raymond S.L. Chang, Bang-Lin Wan, Dai-Shi Su, C. Meacham Harrell
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(11)
Selective bradykinin (BK) B1 receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure–activity relationships of the bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec292e3e55ff7ef2aeb1a8fe08101015
https://pubmed.ncbi.nlm.nih.gov/17428657
https://pubmed.ncbi.nlm.nih.gov/17428657
Autor:
Dai-Shi Su, Kathryn L. Murphy, Sookhee Ha, Rick W. Ransom, Mark G. Bock, Roger M. Freidinger, C. Meacham Harrell, Pat J. Hey, M. Kristine Markowitz, R. S. L. Chang, Fred Hess, Tsing-Bau Chen
Publikováno v:
Biochemical and biophysical research communications. 331(1)
We report the first homology model of human bradykinin receptor B1 generated from the crystal structure of bovine rhodopsin as a template. Using an automated docking procedure, two B1 receptor antagonists of the dihydroquinoxalinone structural class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5851270dfb29bd11987a46d948a7d79
https://pubmed.ncbi.nlm.nih.gov/15845373
https://pubmed.ncbi.nlm.nih.gov/15845373
Autor:
Q. Shen, Rick W. Ransom, Kelem Kassahun, Roger M. Freidinger, Bharat Lagu, Dhanapalan Nagarathnam, Terry W. Schorn, John M. Wetzel, Douglas J. Pettibone, Theodore P. Broten, A. D. Rodrigues, D. Tian, Chao Li, Yoon T. Jeon, Carlos Forray, C. Gluchowski, T.-B. Chan, S. S. O'malley, R. S. L. Chang
Publikováno v:
Journal of medicinal chemistry. 43(15)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed718a4b3548ba91071a4decec212a4f
https://pubmed.ncbi.nlm.nih.gov/10956183
https://pubmed.ncbi.nlm.nih.gov/10956183
Autor:
Kelem Kassahun, Philippe G. Nantermet, Roger M. Freidinger, Timothy V. Olah, Carlos Forray, Harold G. Selnick, Thomas G. Steele, Theodore P. Broten, James C. Barrow, Kenneth E. Rittle, Raymond S.L. Chang, Duane R. Reiss, Carl F. Homnick, Rick W. Ransom, Paul J. Kling, Kristen L. Glass, A. Barrish, Kevin F. Gilbert, Paula Leppert, Stacey O'Malley, Dhanapalan Nagarathnam, Terry W. Schorn, Joan D. Ellis
Publikováno v:
Journal of medicinal chemistry. 43(14)
alpha(1) Adrenergic receptors mediate both vascular and lower urinary tract tone, and alpha(1) receptor antagonists such as terazosin (1b) are used to treat both hypertension and benign prostatic hyperplasia (BPH). Recently, three different subtypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ce2b550eb2c84ebbbcca4a081f4a14
https://pubmed.ncbi.nlm.nih.gov/10893308
https://pubmed.ncbi.nlm.nih.gov/10893308
Autor:
Howard Y. Chen, Joseph A. Borkowski, Myrna E. Trumbauer, Catherine D. Strader, Guy R. Seabrook, J.F. Hess, Rick W. Ransom, Raymond G. Hill
Publikováno v:
The Journal of biological chemistry. 270(23)
Mice that are homozygous for the targeted disruption of the gene encoding the B2 bradykinin receptor have been generated. The gene disruption results in a deletion of the entire coding sequence for the B2 receptor. The disruption of the B2 receptor g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda6c6ef714179600b584d3553288acc
https://pubmed.ncbi.nlm.nih.gov/7775424
https://pubmed.ncbi.nlm.nih.gov/7775424