Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Rick T Owens"'
Autor:
Simone Buraschi, Thomas Neill, Rick T Owens, Leonardo A Iniguez, George Purkins, Rajanikanth Vadigepalli, Barry Evans, Liliana Schaefer, Stephen C Peiper, Zi-Xuan Wang, Renato V Iozzo
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45559 (2012)
Decorin, a member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis by directly targeting and antagonizing multiple receptor tyrosine kinases, such as the EGFR
Externí odkaz:
https://doaj.org/article/412b354afa804efdacc6e3aad012a408
Autor:
Oliver Jungmann, Katerina Nikolovska, Christian Stock, Jan-Niklas Schulz, Beate Eckes, Christoph Riethmüller, Rick T Owens, Renato V Iozzo, Daniela G Seidler
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50809 (2012)
Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling. Loss of the dermatan sulfate of decorin leads to an Ehlers-Danlos syndrome characterize
Externí odkaz:
https://doaj.org/article/4d7eac7c63834d10803e3047137d79b0
Publikováno v:
The Journal of Biological Chemistry
Macroautophagy is a fundamental and evolutionarily conserved catabolic process that eradicates damaged and aging macromolecules and organelles in eukaryotic cells. Decorin, an archetypical small leucine-rich proteoglycan, initiates a protracted autop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18d83b0df339199d179e0125158b27c
https://doi.org/10.1074/jbc.m116.769950
https://doi.org/10.1074/jbc.m116.769950
Publikováno v:
Matrix Biology. 35:42-50
The highly conserved eukaryotic process of macroautophagy (autophagy) is a non-specific bulk-degradation program critical for maintaining proper cellular homeostasis, and for clearing aged and damaged organelles. This decision is inextricably depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f00075eec4bd80f4593168b3e20b85
https://doi.org/10.1016/j.matbio.2014.04.002
https://doi.org/10.1016/j.matbio.2014.04.002
Publikováno v:
Matrix Biology. 35:266-275
Preterm birth is the leading cause of newborn mortality in the United States and about one third of cases are caused by preterm premature rupture of fetal membranes, a complication that is frequently observed in patients with Ehlers-Danlos Syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454d2d0846bfac11e481bc056928d1d3
Autor:
Simone Buraschi, Liliana Schaefer, Rick T. Owens, Hannah Painter, Renato V. Iozzo, Thomas Neill, Michael P. Lisanti
Publikováno v:
Journal of Biological Chemistry. 287:5492-5506
Decorin, a small leucine-rich proteoglycan, inhibits tumor growth by antagonizing multiple receptor tyrosine kinases including EGFR and Met. Here, we investigated decorin during normoxic angiogenic signaling. An angiogenic PCR array revealed a profou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77fdd46b497c1f2ee37e296ef1df1f22
https://doi.org/10.1074/jbc.m111.283499
https://doi.org/10.1074/jbc.m111.283499
Publikováno v:
Carcinogenesis. 32:1518-1524
Human epidemiological studies have shown that diets enriched in n-3 polyunsaturated fatty acids (n-3 PUFA) are associated with a lower incidence of cancers including breast cancer. Our previous studies showed that the n-3 PUFA, docosahexaenoic acid (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a49414edb53cb77a96a11b1410f4916
https://doi.org/10.1093/carcin/bgr132
https://doi.org/10.1093/carcin/bgr132
Autor:
Rick T. Owens, Yong Q. Chen, Joseph T. O'Flaherty, Yunping Hu, Iris J. Edwards, Jansheng Wu, Haiguo Sun, Zhennan Gu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 10, Pp 826-836 (2010)
Evidence indicates that diets enriched in n-3 polyunsaturated fatty acids (n-3 PUFAs) reduce the risk of prostate cancer, but biochemical mechanisms are unclear. Syndecan-1 (SDC-1), a transmembrane heparan sulfate proteoglycan, supports the integrity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c003da96c6d6dedf221175236fa72a
http://www.sciencedirect.com/science/article/pii/S1476558610800508
http://www.sciencedirect.com/science/article/pii/S1476558610800508
Autor:
Alexander Nyström, Renato V. Iozzo, Sampurna Sattar, Silvia Goldoni, Rick T. Owens, David J. McQuillan, Ashley C. Humphries, Keith Ireton
Publikováno v:
The Journal of Cell Biology
Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell growth by down-regulating the epidermal growth factor receptor. Decorin has a complex binding repertoire, thus, we predicted that decorin would modulate the bioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e93c1869ce6298f3e27aad018d9449
https://doi.org/10.1083/jcb.200901129
https://doi.org/10.1083/jcb.200901129
Autor:
Wittaya Pimtong, Renato V. Iozzo, Helen Corby, Jason J. Zoeller, Rick T. Owens, Silvia Goldoni, Shiu-Ying Ho, Alex E. Iozzo
Publikováno v:
Journal of Biological Chemistry. 284:11728-11737
Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, regulates collagen fibrillogenesis and cell growth. To further explore its biological function, we examined the role of Decorin during zebrafish development. Zebrafish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d6e5828a8b0e63599fbcf775ab5993
https://doi.org/10.1074/jbc.m808991200
https://doi.org/10.1074/jbc.m808991200