Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rick R. Adler"'
Publikováno v:
Journal of Histotechnology. 39:2-7
Intracellular accumulation of excessive glycogen or lipid in the liver occurs as a manifestation of metabolic dysfunction or drug-induced toxicity in humans or animals. The identification of individual components (lipids, glycogen, or water) involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e89f597b6ec2a57fbf98e37f27bafc
https://doi.org/10.1080/01478885.2015.1106072
https://doi.org/10.1080/01478885.2015.1106072
Autor:
C. M. Merrill, K. Mellon-Kusibab, David H. Melich, Sundeep A. Chandra, Rick R. Adler, David Bailey, Richard A. Peterson
Publikováno v:
Journal of Applied Toxicology. 34:857-861
Petrolatum is widely used in cosmetics, topical pharmaceuticals and also as a vehicle in dermal toxicity studies. New Zealand white rabbits treated with white petrolatum (vehicle control) in a 2-week dermal irritation study exhibited moderate to seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10284840a902307eef9d5d0506460aa0
https://doi.org/10.1002/jat.2895
https://doi.org/10.1002/jat.2895
Autor:
Brian R. Berridge, Malcolm York, A. Casartelli, Kimberly Roland, Rick R. Adler, Alan H. Stokes, Rhiannon C. Davies, Patrizia Cristofori, Federica Crivellente, Carie L. Kimbrough, Franck Chanut, Rick Hailey, Holly L. Jordan, Jan Klapwijk, Angela Hughes-Earle, Heath C. Thomas
Publikováno v:
Toxicologic Pathology. 41:1126-1136
Cardiovascular safety signals in nonclinical studies remain among the main reasons for drug attrition during pharmaceutical research and development. Drug-induced changes can be functional and/or associated with morphological alterations in the norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ccb664db9eb246bb3ccc29e45c39a3
https://doi.org/10.1177/0192623313478692
https://doi.org/10.1177/0192623313478692
Autor:
Beverly E. Maleeff, Patrizia Cristofori, Rick R. Adler, Charlotte M. Keenan, Angela Hughes-Earle, Jan Klapwijk, Heath C. Thomas
Publikováno v:
Toxicologic Pathology. 38:995-998
Toxicologic pathologists are tasked with morphologic evaluation of tissues in animal toxicity studies to ascertain drug or chemical-related effects. These assessments are based on knowledge of the species and spectrum of morphologic changes that occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9882cb5b0b3bfca3066ee2cc9bffd06b
https://doi.org/10.1177/0192623310378868
https://doi.org/10.1177/0192623310378868
Autor:
Sundeep A. Chandra, Christine L. Merrill, Richard A. Peterson, Kristina DeSmet, David H. Melich, Katherine Mellon-Kusibab, Rick R. Adler, Alan H. Stokes, Rick Hailey, Sylvia Furst
Publikováno v:
Toxicologic pathology. 43(4)
The field of dermal toxicity continues to evolve in order to accurately predict dermal (and systemic) responses in humans to topically applied chemicals. Although the testing methods have undergone extensive refinements, idiosyncrasies and unexpected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c501d7144f75b9c1d919ea4b6873ef
https://pubmed.ncbi.nlm.nih.gov/25389277
https://pubmed.ncbi.nlm.nih.gov/25389277
Autor:
Rick R. Adler, Jeffrey I. Everitt
Numerous genetic, microbial, environmental, and experimental factors work together to influence development of the lesions studied by the toxicologic pathologist. The pathologist needs to understand how factors associated with the laboratory animal,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95812d025a30da8bea3ceebeac9a7f11
https://doi.org/10.1016/b978-0-12-415759-0.00020-0
https://doi.org/10.1016/b978-0-12-415759-0.00020-0
Publikováno v:
Toxicologic pathology. 38(6)
Interpretation of chemical-induced effects on the female beagle mammary gland can be difficult owing to the wide variation of normal glandular morphology. In this retrospective study, morphological features of the gland in four (proestrus, estrus, di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfe9b13c1143edf1fad5c79d1babfb8
https://pubmed.ncbi.nlm.nih.gov/20651098
https://pubmed.ncbi.nlm.nih.gov/20651098
Autor:
Rick R. Adler, Sundeep A. Chandra
Publikováno v:
Toxicologic pathology. 36(7)
The beagle is a monoestric, nonseasonal breeder with a long estrous cycle. Owing to lengthy stages in individual phases of the estrous cycle, limited group size, and typical group assignment focused on homogenized body weight, dogs in the same stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d30c6a240dc3792dce7b5e7d6b05e9
https://pubmed.ncbi.nlm.nih.gov/19126790
https://pubmed.ncbi.nlm.nih.gov/19126790
Publikováno v:
Drug discovery today. 13(17-18)
Drug effects on mitochondrial function are frequently characterized in vitro. Whether these findings are relevant pharmacologically or toxicologically is generally unclear. Methods for in vivo assessment of mitochondrial function would help establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cabeb63d461ac2dbe37fb889f80bfed
https://pubmed.ncbi.nlm.nih.gov/18577467
https://pubmed.ncbi.nlm.nih.gov/18577467
Autor:
Rick R. Adler, John E. Burkhardt, Roy L. Kerlin, Eugenia Floyd, Jack A. Reynolds, Ricardo Ochoa
Publikováno v:
Toxicologic pathology. 27(4)
Most nonclinical safety studies performed to satisfy regulatory requirements include numerous anatomic and clinical pathology endpoints. Consequently, the traditional predominant role of the pathologist in the pharmaceutical industry has focused upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d37ec16086b1e02c08ee6792bad379
https://pubmed.ncbi.nlm.nih.gov/10485831
https://pubmed.ncbi.nlm.nih.gov/10485831