Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rick L. Horetsky"'
Autor:
Anita K. Hopper, Leonard S. Jefferson, Athulaprabha Murthi, Scot R. Kimball, Hussam H. Shaheen, Rick L. Horetsky
Publikováno v:
Proceedings of the National Academy of Sciences. 104:8845-8850
Until recently, transport of tRNA was presumed to be unidirectional, from the nucleus to the cytoplasm. Our published findings, however, revealed that cytoplasmic tRNAs move retrograde to the nucleus in Saccharomyces cerevisiae and that nuclear accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931e59bd49d4d5bae8fe49da776612aa
https://doi.org/10.1073/pnas.0700765104
https://doi.org/10.1073/pnas.0700765104
Autor:
Michael J. Clemens, Vivienne J. Tilleray, Leonard S. Jefferson, Ronald C. Wek, Rick L. Horetsky, Scot R. Kimball
Publikováno v:
Biochemical and Biophysical Research Communications. 280:293-300
The alpha-subunit of eukaryotic initiation factor eIF2 is a preferred substrate for the double-stranded RNA-activated protein kinase, PKR. Phosphorylation of eIF2alpha converts the factor from a substrate into a competitive inhibitor of the guanine n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b251dcf74c77967b4196d8fae7ab38
https://doi.org/10.1006/bbrc.2000.4103
https://doi.org/10.1006/bbrc.2000.4103
Publikováno v:
Protein Expression and Purification. 12:415-419
The alpha-subunit of eukaryotic initiation factor eIF2 (eIF2alpha) plays an important role in the regulation of mRNA translation through modulation of the interaction of eIF2 and a second initiation factor, eIF2B. The interaction of the two proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad960701ccd5d4e91435abe1c30da6f7
https://doi.org/10.1006/prep.1998.0863
https://doi.org/10.1006/prep.1998.0863
Publikováno v:
Journal of Biological Chemistry. 273:3039-3044
Modulation of protein/protein interaction is an important mechanism involved in regulation of translation initiation. Specifically, regulation of the interaction of eIF2 with the guanine nucleotide exchange factor, eIF2B, is a key mechanism for contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e43000e1f06a198ac683181787697aa
https://doi.org/10.1074/jbc.273.5.3039
https://doi.org/10.1074/jbc.273.5.3039
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 28:285-294
Protein synthesis is inhibited in both rat liver and isolated rat hepatocytes following deprivation of single essential amino acids. The aim of the present study was to define the time course of changes in peptide-chain initiation, albumin synthesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1989ff29b104e58d39fa0627e65c89d3
https://doi.org/10.1016/1357-2725(95)00143-3
https://doi.org/10.1016/1357-2725(95)00143-3
Publikováno v:
Journal of Biological Chemistry. 268:25277-25284
The studies presented herein were designed to investigate the role of insulin in maintaining the steady-state number of ribosomes in primary cultures of rat hepatocytes. The RNA content of hepatocytes maintained in the presence of insulin did not cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9d7e116a298498426559fb4104795e9
https://doi.org/10.1016/s0021-9258(19)74389-0
https://doi.org/10.1016/s0021-9258(19)74389-0
Publikováno v:
Analytical biochemistry. 325(2)
Modulation of interactions among proteins is an important mechanism for regulating both the subcellular location and the function of proteins. An example of the importance of protein–protein interaction is the reversible association of eukaryotic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d2a493cbed8c88dd4ebaa2023e92a4
https://pubmed.ncbi.nlm.nih.gov/14751272
https://pubmed.ncbi.nlm.nih.gov/14751272
Autor:
Rick L. Horetsky, Scot R. Kimball
Publikováno v:
The international journal of biochemistrycell biology. 33(8)
Interaction of the translational repressor 4E-BP1 with the mRNA cap binding protein eIF4E plays an important role in the regulation of translation initiation. This interaction is modulated by phosphorylation of 4E-BP1 on at least six residues. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a780355d03e2a5b41f219efaa4da92c0
https://pubmed.ncbi.nlm.nih.gov/11404183
https://pubmed.ncbi.nlm.nih.gov/11404183
Publikováno v:
The Journal of biological chemistry. 274(17)
Regulation of translation of mRNAs coding for specific proteins plays an important role in controlling cell growth, differentiation, and transformation. Two proteins have been implicated in the regulation of specific mRNA translation: eukaryotic init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a29da122db6471faa20b8a476e89306
https://pubmed.ncbi.nlm.nih.gov/10206976
https://pubmed.ncbi.nlm.nih.gov/10206976
Publikováno v:
The Journal of biological chemistry. 273(47)
The present study was designed to investigate the mechanism through which leucine and histidine regulate translation initiation in L6 myoblasts. The results show that both amino acids stimulate initiation and coordinately regulate the activity of euk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5836ab771f623b898d1fd3c99a9392e8
https://pubmed.ncbi.nlm.nih.gov/9812990
https://pubmed.ncbi.nlm.nih.gov/9812990