Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rick L. Barr"'
Autor:
Jason R.B. Dyck, Amy J. Barr, Gary D. Lopaschuk, Rick L. Barr, Paul F. Kantor, Panakkezhum D. Thomas, Marc Prentki, Luc G. Berthiaume, Dyal Singh, Teresa A. Hopkins, Nicolas Voilley
Publikováno v:
Biochemical Journal. 350:599-608
In the liver, malonyl-CoA is central to many cellular processes, including both fatty acid biosynthesis and oxidation. Malonyl-CoA decarboxylase (MCD) is involved in the control of cellular malonyl-CoA levels, and functions to decarboxylate malonyl-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7acc90c97efdb64534950eb8b535c92c
https://doi.org/10.1042/bj3500599
https://doi.org/10.1042/bj3500599
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 275:H2122-H2129
Malonyl-CoA is a potent inhibitor of fatty acid uptake into the mitochondria. Although the synthesis of malonyl-CoA in the heart by acetyl-CoA carboxylase (ACC) has been well characterized, no information is available as to how malonyl-CoA is degrade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b12747d2c0cc13fa642ad72076fe42
https://doi.org/10.1152/ajpheart.1998.275.6.h2122
https://doi.org/10.1152/ajpheart.1998.275.6.h2122
Autor:
Gary D. Lopaschuk, Rick L. Barr
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 38:11-17
Fatty acids and carbohydrates are the two main energy substrates used by the heart. Studies involving the regulation of these pathways in the heart have historically been hampered by a number of important technical problems. One problem is the need t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d0ab2eb75ccb93fe838ec91a9d086c
https://doi.org/10.1016/s1056-8719(97)86574-4
https://doi.org/10.1016/s1056-8719(97)86574-4
Autor:
Gary D. Lopaschuk, Rick L. Barr
Publikováno v:
Molecular and Cellular Biochemistry. 172:137-147
The isolated working rat heart is a useful experimental model which allows contractile function to be measured in hearts perfused at physiologically relevant workloads. To maintain these high workloads the heart is required to generate a tremendous a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e346a679baf1b036b4426f1f94062897
https://doi.org/10.1023/a:1006875823561
https://doi.org/10.1023/a:1006875823561
Publikováno v:
Circulation. 93:135-142
Background Ranolazine is a novel antianginal agent that may reduce symptoms without affecting hemodynamics and has shown cardiac antiischemic effects in in vivo and in vitro models. In one study it increased active pyruvate dehydrogenase (PDHa). Othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea110ab832cc315217920ebc393376ee
https://doi.org/10.1161/01.cir.93.1.135
https://doi.org/10.1161/01.cir.93.1.135
Publikováno v:
Journal of Biological Chemistry. 269:25871-25878
Fatty acid oxidation rapidly increases in the rabbit heart following birth. By inhibiting carnitine palmitoyltransferase 1 (CPT1), malonyl-CoA is a potent regulator of fatty acid oxidation in the heart. We therefore addressed the hypothesis that a de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dadb9806c2064a5a2f815760cff116f
https://doi.org/10.1016/s0021-9258(18)47327-9
https://doi.org/10.1016/s0021-9258(18)47327-9
Publikováno v:
Metabolism. 41:332-338
We have previously demonstrated that withdrawal of insulin treatment from BB diabetic rats for a 24-hour period will increase the failure rate of hearts subjected to low-flow ischemia. The purpose of this study was to determine if this increased seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cde627ce27bc845e1a09d5672fbd343
https://doi.org/10.1016/0026-0495(92)90280-n
https://doi.org/10.1016/0026-0495(92)90280-n
Autor:
Eoin O'leary, Guang Yang, Miguel Barbosa, Jason R.B. Dyck, Larry Liu, Masahiro Nishimoto, Rick L. Barr, Alex M. Nadzan, Yujin Huang, Jie-Fei Cheng, Richard Penuliar, Thomas Arrhenius, Gary D. Lopaschuk
Publikováno v:
Journal of medicinal chemistry. 49(14)
Discovery of 5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamides as a new class of malonyl-coenzyme A decarboxylase (MCD) inhibitors is described. tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3adaff158fc64b982008aba4a4bc2e3
https://pubmed.ncbi.nlm.nih.gov/16821767
https://pubmed.ncbi.nlm.nih.gov/16821767
Autor:
Bin Liu, Gary D. Lopaschuk, Thomas Arrhenius, Steven Brown, Charles Harmon, Rick L. Barr, David Wallace, Vicki Thorn, Jason R.B. Dyck, Jie-Fei Cheng, Souvothy Tith, Sean Reily, Mi Chen, Masayuki Haramura, Chi Ching Mak, Alex M. Nadzan
Publikováno v:
Journal of medicinal chemistry. 49(5)
The discovery and structure−activity relationship of first-generation small-molecule malonyl-CoA decarboxylase (MCD; CoA = coenzyme A) inhibitors are reported. We demonstrated that MCD inhibitors increased malonyl-CoA concentration in the isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4011430eb921a7827366b2da9ddafa18
https://pubmed.ncbi.nlm.nih.gov/16509570
https://pubmed.ncbi.nlm.nih.gov/16509570
Autor:
Steven Brown, Margaret P. Chandler, Rick L. Barr, Alex M. Nadzan, David Wallace, Charles Harmon, Gary D. Lopaschuk, Guang Yang, Jason R.B. Dyck, William C. Stanley, Jie-Fei Cheng, Thomas Arrhenius
Publikováno v:
Circulation Research. 94
Abnormally high rates of fatty acid oxidation and low rates of glucose oxidation are important contributors to the severity of ischemic heart disease. Malonyl coenzyme A (CoA) regulates fatty acid oxidation by inhibiting mitochondrial uptake of fatty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cb9ff8c94af11fdeeeac453a7f80d9
https://doi.org/10.1161/01.res.0000129255.19569.8f
https://doi.org/10.1161/01.res.0000129255.19569.8f