Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rick Kornelsen"'
Autor:
Noeen, Malik, Rick, Kornelsen, Siobhan, McCormick, Nadine, Colpo, Helen, Merkens, Shreya, Bendre, Francois, Benard, Vesna, Sossi, Ralf, Schirrmacher, Paul, Schaffer
Publikováno v:
European journal of medicinal chemistry. 211
Among all genetic mutations of LRRK2, the G2019S mutation is the most commonly associated with the late-onset of Parkinson's disease (PD). Hence, one potential therapeutic approach is to block the hyperactivity of mutated LRRK2 induced by kinase inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e0d09ce05f38c6e8bf02e56064e74725
https://pubmed.ncbi.nlm.nih.gov/33248850
https://pubmed.ncbi.nlm.nih.gov/33248850
Autor:
Cornelia Hoehr, Andrew Yung, Piotr Kozlowski, Rick Kornelsen, Geoffrey J. Topping, Vesna Sossi, Paul Schaffer
Publikováno v:
Medical Physics. 44:4056-4067
Purpose Mn2+ is used a contrast agent and marker for neuronal activity with magnetic resonance imaging (MRI) in rats and mice, but its accumulation is generally not assessed quantitatively. In this work, non-radioactive Mn and 52Mn are injected simul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fce171a8cd7cb7e717ecd8c89c2c509
https://doi.org/10.1002/mp.12300
https://doi.org/10.1002/mp.12300
Autor:
Paul Schaffer, Vesna Sossi, Francois Benard, Nadine Colpo, Rick Kornelsen, Ralf Schirrmacher, Helen Merkens, Siobhan McCormick, Noeen Malik, Shreya Bendre
Publikováno v:
European Journal of Medicinal Chemistry. 211:113005
Purpose Among all genetic mutations of LRRK2, the G2019S mutation is the most commonly associated with the late-onset of Parkinson’s disease (PD). Hence, one potential therapeutic approach is to block the hyperactivity of mutated LRRK2 induced by k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a8097f30db0719d52fea4a19b9f35d8
https://doi.org/10.1016/j.ejmech.2020.113005
https://doi.org/10.1016/j.ejmech.2020.113005
Autor:
Rick Kornelsen, Matthew D. Walker, Vesna Sossi, Qing Miao, Mike Adam, Matthew J. Farrer, Christine Takhar, Nathan V. Lee, Edwin Mak, Katherine Dinelle, Michael Schulzer
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 35:1331-1338
Neuroinflammation in the aging rat brain was investigated using [11C]PBR28 microPET (positron emission tomography) imaging. Normal rats were studied alongside LRRK2 p.G2019S transgenic rats; this mutation increases the risk of Parkinson's disease in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd57a16f26b8dda3def9bf0fbd461edf
https://doi.org/10.1038/jcbfm.2015.54
https://doi.org/10.1038/jcbfm.2015.54
Autor:
Siobhan McCormick, A. Jon Stoessl, Matthew J. Farrer, James E. Holden, Vesna Sossi, Katherine Dinelle, Chenoa Mah, Matthew D. Walker, Rick Kornelsen
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 33:59-66
Longitudinal measurements of dopamine (DA) uptake and turnover in transgenic rodents may be critical when developing disease-modifying therapies for Parkinson's disease (PD). We demonstrate methodology for such measurements using [18F]fluoro-3,4-dihy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676ab68ee3207426a41593173b0dfaf8
https://doi.org/10.1038/jcbfm.2012.120
https://doi.org/10.1038/jcbfm.2012.120
Autor:
Natalja Funk, Mattia Volta, Matthew J. Farrer, Chenoa Mah, Jaskaran Khinda, Rick Kornelsen, Kimberley Co, Sabrina Bergeron, Katrina Yu, Saskia Biskup, Patrick Chou, Thomas Ott, A. Jon Stoessl, Vesna Sossi, Katherine Dinelle, Lise N. Munsie, Olaf Riess, Austen J. Milnerwood, Matthew D. Walker, Marta Mroczek, Stefano Cataldi, Li Ping Cao, Dayne Beccano-Kelly, Dagmar Galter
Publikováno v:
Journal of Parkinson's Disease 4(3), 483-498 (2014). doi:10.3233/JPD-140344
BACKGROUND A major risk-factor for developing Parkinson's disease (PD) is genetic variability in leucine-rich repeat kinase 2 (LRRK2), most notably the p.G2019S mutation. Examination of the effects of this mutation is necessary to determine the etiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd02b05ebe9314828bf5440bff46f644
Autor:
James E. Holden, A. Jon Stoessl, Siobhan McCormick, Matthew D. Walker, Matthew J. Farrer, Katherine Dinelle, Chenoa Mah, Rick Kornelsen, Anna Lee, Vesna Sossi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53f98d1df507048f437a4dbd09f46e5d
https://doi.org/10.1016/b978-0-12-800044-1.00144-6
https://doi.org/10.1016/b978-0-12-800044-1.00144-6
Autor:
James E. Holden, Rick Kornelsen, Siobhan McCormick, Geoffrey J. Topping, Vesna Sossi, Katie Dinelle
Publikováno v:
Synapse (New York, N.Y.). 64(3)
Small animal positron emission tomography (PET) imaging allows in vivo quantification of lesion- or treatment-induced neurochemical changes in animal models of disease. Important for quantification are the kinetic modeling methods used to determine b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccfa3acfbae6afe099f8a30b4d688b9
https://pubmed.ncbi.nlm.nih.gov/19862685
https://pubmed.ncbi.nlm.nih.gov/19862685
Autor:
Patrick L, McGeer, Edward, Tobinick, Rick, Kornelsen, Siobhan, McCormick, Cara, Ferreira, Suzanne, Lapi, Thomas J, Ruth
Publikováno v:
Journal of Alzheimer's disease : JAD.
Ahead of Print article withdrawn by publisher.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d7a4e6da5b997ad644d2ba9159d795a
https://pubmed.ncbi.nlm.nih.gov/19433894
https://pubmed.ncbi.nlm.nih.gov/19433894
Publikováno v:
2007 IEEE Nuclear Science Symposium Conference Record.
Accurate methods are required for analysis of microPET dopamine (DA) receptor or transporter images of unilaterally 6-hydroxydopamine-lesioned rat models of Parkinson's disease. Heavily lesioned striata and the cerebellum do not appear distinctly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16e8289c18f864fe89527ab853a86a69
https://doi.org/10.1109/nssmic.2007.4436744
https://doi.org/10.1109/nssmic.2007.4436744