Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rick Jack"'
Autor:
Tsuyoshi Ogiku, James Zapf, Shao-Hui Zhang, Kui Xu, Kei Takedomi, Naoki Sakurai, Guang Yang, Rick Jack, Jie-Fei Cheng, Miguel Barbosa, Chiaki Fukushima
Publikováno v:
Journal of Medicinal Chemistry. 51:2057-2061
We conducted virtual docking studies using GLIDE with modified LXRbeta ligand-binding domain (LBD) on internal compound collection followed by the gene profiling with ArrayPlate mRNA assay. A total of 69 compounds were found to upregulate LXRalpha an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c423f07eaac7c8768ae34ef8ec2901
https://doi.org/10.1021/jm7011326
https://doi.org/10.1021/jm7011326
Autor:
Madhavi Pannala, Sunil Kher, Ila Sircar, Rick Jack, Kirk Lake, Shao-Hui Zhang, James Zapf, Lisa Morera, Juping Liu, Kui Xu, Farid Bakir, Jie-Fei Cheng, Naoki Sakurai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4442-4446
Structure-activity relationship studies on a series of Boc-indole derivatives as LXR agonists are described. Compound 1 was identified as an LXR agonist through structure-based virtual screening followed by high-throughput gene profiling. Replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b33d8f8884334c3855313d44722c5fe
https://doi.org/10.1016/j.bmcl.2007.06.017
https://doi.org/10.1016/j.bmcl.2007.06.017
Autor:
Ila Sircar, Chiaki Fukushima, Lisa Schneider, James Zapf, Madhavi Pannala, Lisa Morera, Trang Nguyen, Jie-Fei Cheng, Rick Jack, Norma Wilson, Shao-Hui Zhang, Kui Xu, Farid Bakir, Juping Liu, Kei Takedomi, Naoki Sakurai, Sunil Kher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3473-3479
A structurally novel liver X receptor (LXR) agonist (1) was identified from internal compound collection utilizing the combination of structure-based virtual screening and high-throughput gene profiling. Compound 1 increased ABCA1 gene expression by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7eb508e31f7c0f8a1fb69a6abab291c
https://doi.org/10.1016/j.bmcl.2007.03.076
https://doi.org/10.1016/j.bmcl.2007.03.076
Publikováno v:
Journal of Biomolecular NMR. 22:165-173
Genomic research on target identification and validation has created a great need for methods that rapidly provide detailed structural information on protein-ligand interactions. We developed a suite of NMR experiments as rapid and efficient tools to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a593727e1d9e48c0d716a572a3ea5639
https://doi.org/10.1023/a:1014256707875
https://doi.org/10.1023/a:1014256707875
Autor:
Rick Jack, Jie-Fei Cheng
Publikováno v:
Molecular diversity. 12(1)
CCR1 (CC Chemokine receptor 1) is a widely studied G protein-coupled receptor target expressed on multiple types of leukocytes. It is implicated in initiating and exacerbating inflammatory conditions and thus is viewed as a good target for autoimmune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc6f588b80b4f445fee9ec05f4e7346
https://pubmed.ncbi.nlm.nih.gov/18560988
https://pubmed.ncbi.nlm.nih.gov/18560988
Autor:
Kirk Lake, Jason Parise, Juping Liu, Ila Sircar, Rick Jack, Naoki Sakurai, Jian Li, Gobi Nagarajan, Lisa Schneider, Miguel Barbosa, Kevin Dines, Kathleen Ligsay, Ding Huang, Yun Feng Xie, Mallareddy Komandla, Kui Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(12)
Design and synthesis of a series of 3-amino-4-(2-(2-(4-benzylpiperazin-1-yl)-2-oxoethoxy)phenylamino)cyclobutenedione derivatives as novel CCR1 antagonists are described. Structure-activity relationship studies led to the identification of compound 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74976f2785bdbf2a07cf37dfa853a5a9
https://pubmed.ncbi.nlm.nih.gov/17446072
https://pubmed.ncbi.nlm.nih.gov/17446072
Publikováno v:
Journal of biomolecular NMR. 22(2)
Genomic research on target identification and validation has created a great need for methods that rapidly provide detailed structural information on protein-ligand interactions. We developed a suite of NMR experiments as rapid and efficient tools to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::985e2e0e182c830fa1ef76df925f0600
https://pubmed.ncbi.nlm.nih.gov/11883777
https://pubmed.ncbi.nlm.nih.gov/11883777
Publikováno v:
Journal of cellular biochemistry. Supplement.
As a result of genomics efforts, the number of protein drug targets is expected to increase by an order of magnitude. Functional genomics efforts are identifying these targets, while structural genomics efforts are determining structures for many of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d05f41951b884feb42e3fef2271523
https://pubmed.ncbi.nlm.nih.gov/11842434
https://pubmed.ncbi.nlm.nih.gov/11842434
Autor:
David Meininger, Maurizio Pellecchia, Daniel S. Sem, Charles B. Kasper, Rick Jack, Anna L. Shen
Publikováno v:
Journal of the American Chemical Society. 123(19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2275844c6433ad73ec1c17df3a3c7289
https://pubmed.ncbi.nlm.nih.gov/11457263
https://pubmed.ncbi.nlm.nih.gov/11457263
Autor:
Jie-Fei Cheng, James Zapf, Kei Takedomi, Chiaki Fukushima, Tsuyoshi Ogiku, Shao-Hui Zhang, Guang Yang, Naoki Sakurai, Miguel Barbosa, Rick Jack, Kui Xu
Publikováno v:
Journal of Medicinal Chemistry; Mar2008, Vol. 51 Issue 7, p2057-2061, 5p