Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Rick Gussio"'
Autor:
Erkan Kiris, Jonathan E Nuss, Stephanie M Stanford, Laura M Wanner, Lisa Cazares, Michael F Maestre, Hao T Du, Glenn Y Gomba, James C Burnett, Rick Gussio, Nunzio Bottini, Rekha G Panchal, Christopher D Kane, Lino Tessarollo, Sina Bavari
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129264 (2015)
There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts focus on directly inhibiting the proteolytic components of BoNT, i.e. light chains (LC). Al
Externí odkaz:
https://doaj.org/article/60298f029db949189b12f9558abf609f
Autor:
Emanuela Screpanti, Stefano Santaguida, Tam Nguyen, Romano Silvestri, Rick Gussio, Andrea Musacchio, Ernest Hamel, Peter De Wulf
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11603 (2010)
Protein assemblies named kinetochores bind sister chromatids to the mitotic spindle and orchestrate sister chromatid segregation. Interference with kinetochore activity triggers a spindle checkpoint mediated arrest in mitosis, which frequently ends i
Externí odkaz:
https://doaj.org/article/7ca874e015d641ce92860e9a3c6dd90f
Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A.
Autor:
Jorge E Zuniga, Jared T Hammill, Omri Drory, Jonathan E Nuss, James C Burnett, Rick Gussio, Peter Wipf, Sina Bavari, Axel T Brunger
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11378 (2010)
The botulinum neurotoxin serotype A light chain (BoNT/A LC) protease is the catalytic component responsible for the neuroparalysis that is characteristic of the disease state botulism. Three related peptide-like molecules (PLMs) were designed using p
Externí odkaz:
https://doaj.org/article/a34e88d467e840418644c1507b4c85d7
Autor:
Peter De Wulf, Rick Gussio, Paola Conti, Ernest Hamel, Leonardo Lo Presti, Andrea Pinto, Maria Rosaria Cera, Tam Luong Nguyen
PDF file, 223KB, Growth inhibition profiles of the NCI60 tumor cell lines by S-A8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542ba844de8f46a21bc3c2bbd47dc23a
https://doi.org/10.1158/1535-7163.22498107
https://doi.org/10.1158/1535-7163.22498107
Autor:
Peter De Wulf, Rick Gussio, Paola Conti, Ernest Hamel, Leonardo Lo Presti, Andrea Pinto, Maria Rosaria Cera, Tam Luong Nguyen
PDF file, 152KB, 1H NMR spectrum of (�)-Boc-A8. The lower panel details the spectrum between 6.4 and 2.4 ppm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a1aefd278645e6c14b10493b884634
https://doi.org/10.1158/1535-7163.22498113
https://doi.org/10.1158/1535-7163.22498113
Autor:
Peter De Wulf, Rick Gussio, Paola Conti, Ernest Hamel, Leonardo Lo Presti, Andrea Pinto, Maria Rosaria Cera, Tam Luong Nguyen
Tumor resistance to antitubulin drugs resulting from P-glycoprotein (Pgp) drug-efflux activity, increased expression of the βIII tubulin isotype, and alterations in the drug-binding sites are major obstacles in cancer therapy. Consequently, novel an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c62ecf520f5414769a98892858cdaa
https://doi.org/10.1158/1535-7163.c.6535791.v1
https://doi.org/10.1158/1535-7163.c.6535791.v1
Autor:
Peter De Wulf, Rick Gussio, Paola Conti, Ernest Hamel, Leonardo Lo Presti, Andrea Pinto, Maria Rosaria Cera, Tam Luong Nguyen
PDF file, 229KB, Growth inhibition profiles of the NCI60 tumor cell lines by R-A8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dff70fb76e690a7021981957ae36793
https://doi.org/10.1158/1535-7163.22498110.v1
https://doi.org/10.1158/1535-7163.22498110.v1
Autor:
Peter Wipf, Rick Gussio, Connor F. McGrath, Melinda G. Hollingshead, James C. Burnett, Joseph M. Salamoun, Ann Hermone, Brian D. Peyser
Mean graph representation of full NCI-60 Log(GI50) results.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f848f9030085744ee0090891f8a2402
https://doi.org/10.1158/1535-7163.22504501
https://doi.org/10.1158/1535-7163.22504501
Autor:
Peter Wipf, Rick Gussio, Connor F. McGrath, Melinda G. Hollingshead, James C. Burnett, Joseph M. Salamoun, Ann Hermone, Brian D. Peyser
One-dose NCI-60 results for compound 1 with DCNP.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cdbf24425ce4be2023cf6d0cddcd6b
https://doi.org/10.1158/1535-7163.22504489
https://doi.org/10.1158/1535-7163.22504489
Autor:
Peter De Wulf, Rick Gussio, Paola Conti, Ernest Hamel, Leonardo Lo Presti, Andrea Pinto, Maria Rosaria Cera, Tam Luong Nguyen
PDF file, 97KB, Legends to the Supplementary Figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623dd66a1d6a0d609cafb5f354407226
https://doi.org/10.1158/1535-7163.22498104
https://doi.org/10.1158/1535-7163.22498104