Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Rick F Nelson"'
Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea
Autor:
Ksenia A. Aaron, Katja Pekrun, Patrick J. Atkinson, Sara E. Billings, Julia M. Abitbol, Ina A. Lee, Yasmin Eltawil, Yuan-Siao Chen, Wuxing Dong, Rick F. Nelson, Mark A. Kay, Alan G. Cheng
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 413-428 (2023)
Adeno-associated virus (AAV)-mediated gene transfer has shown promise in rescuing mouse models of genetic hearing loss, but how viral capsid and promoter selection affects efficacy is poorly characterized. Here, we tested combinations of AAVs and pro
Externí odkaz:
https://doaj.org/article/12dd1baf9a7e41769ec3b2c66b940104
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Cochlear implants (CI) have revolutionized the treatment of patients with severe to profound sensory hearing loss by providing a method of bypassing normal hearing to directly stimulate the auditory nerve. A further advance in the field has been the
Externí odkaz:
https://doaj.org/article/25ef7089e8c749a7894d23de2f02b8b2
Publikováno v:
OTO Open, Vol 7, Iss 2, Pp n/a-n/a (2023)
Abstract Objective Military veterans have high rates of noise‐induced hearing loss (NIHL) which is associated with more significant spiral ganglion neuronal loss. This study explores the relationship between NIHL and cochlear implant (CI) outcomes
Externí odkaz:
https://doaj.org/article/88327c667c1642a09f9c960854c4d50a
Autor:
Dhruv Sharma, Vincent J. Campiti, Michael J. Ye, Mohamad Saltagi, Aaron E. Carroll, Jonathan Y. Ting, Elisa A. Illing, Jae Hong Park, Rick F. Nelson, Sarah J. Burgin
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 6, Iss 1, Pp 129-136 (2021)
Abstract Objective The risk of SARS‐CoV‐2 transmission to healthcare workers through airborne aerosolization during otologic surgery has not been characterized. The objective of this study was to describe and quantify the aerosol generation durin
Externí odkaz:
https://doaj.org/article/c55fc0b8729f412084ad5e2ef2a3e7d1
Publikováno v:
Clinical Case Reports, Vol 9, Iss 10, Pp n/a-n/a (2021)
Abstract While intraosseous cranial myxoma is a rare pathology, it is important for providers to be aware of it, as early diagnosis and treatment is imperative for prognosis. Long‐term follow‐up is needed as high rates of recurrence have been doc
Externí odkaz:
https://doaj.org/article/b608f14ba4804bac9dc93ece175585e8
Autor:
Pei-Ciao Tang, Alpha L. Alex, Jing Nie, Jiyoon Lee, Adam A. Roth, Kevin T. Booth, Karl R. Koehler, Eri Hashino, Rick F. Nelson
Publikováno v:
Stem Cell Reports, Vol 13, Iss 1, Pp 147-162 (2019)
Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear. We combined the use of stem cell-derive
Externí odkaz:
https://doaj.org/article/0b32ffcd58a04aa0900f1c6271a2373f
Autor:
Douglas J, Totten, Nathan T, Connell, Lauren A, Howser, Elaine, Colomb, Morgan M, Sandelski, Cyrus C, Rabbani, Jesse J, Savage, Mitesh V, Shah, Rick F, Nelson
Publikováno v:
Otology & Neurotology. 44:66-71
To describe a tumor resection using the inferior long-axis (ILA) technique for cisternal facial nerve dissection in large vestibular schwannomas (VS).Retrospective case series from 2018 to 2021.Tertiary academic medical center.Patients who underwent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe66b5fa8038a750893e9b20fbac0d4a
https://doi.org/10.1097/mao.0000000000003753
https://doi.org/10.1097/mao.0000000000003753
Autor:
Yuan-Siao Chen, Ernesto Cabrera, Brady J Tucker, Timothy J Shin, Jasmine V Moawad, Douglas J Totten, Kevin T Booth, Rick F Nelson
Publikováno v:
J Med Genet
BackgroundIt is well established that biallelic mutations in transmembrane protease, serine 3 (TMPRSS3) cause hearing loss. Currently, there is controversy regarding the audiological outcomes after cochlear implantation (CI) forTMPRSS3-associated hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae3b448c0081b3c5e90d5dcf8eb6756
https://doi.org/10.1136/jmg-2022-108654
https://doi.org/10.1136/jmg-2022-108654
Publikováno v:
Otology & Neurotology. 43:547-558
To determine root causes leading to misplaced cochlear implant (CI) electrode arrays and discuss their management using a case series and contemporary literature review.Retrospective case review and contemporary literature review.Single tertiary-refe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5aad9c5433e38368528c1f2bb5a6188
https://doi.org/10.1097/mao.0000000000003503
https://doi.org/10.1097/mao.0000000000003503
Publikováno v:
Proceedings of IMPRS. 5
Background/Objective: Transmembrane serine protease 3 (TMPRSS3) is the most common causative hearing loss gene in adults undergoing cochlear implantation and a significant cause of non-syndromic hearing loss. However, the function of TMPRSS3 within t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::720d0c4dd1dca8e1df56057878e36370
https://doi.org/10.18060/26724
https://doi.org/10.18060/26724