Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rick E.W van Leeuwen"'
Autor:
John G. Collard, Louis H. Cohen, Rick E.W van Leeuwen, Pascale Nègre-Aminou, Monique van Erck
Publikováno v:
Biochemical Pharmacology. 61:991-998
The underlying mechanism of the antiproliferative effect of S (simvastatin), a HMG-CoA reductase inhibitor, in vascular smooth muscle cells (SMC) is still poorly understood. In the present study, we used synchronized human SMC, isolated from left int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375b9b817fccdda13c8be86a8a5c1470
https://doi.org/10.1016/s0006-2952(01)00566-4
https://doi.org/10.1016/s0006-2952(01)00566-4
Autor:
Brigitte E. A. Burm, Gijs A. van der Marel, Rick E.W van Leeuwen, Jacques H. van Boom, Louis H. Cohen, Elsbet J. Pieterman, Mark Overhand
Publikováno v:
Biochemical Pharmacology. 60:1061-1068
Anchoring of small G-proteins to cellular membranes via a covalently bound lipophylic prenyl group is essential for the functioning of these proteins. For example, the farnesylation of Ras by the action of the enzyme protein:farnesyl transferase (PFT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fa59dc22386418efbfe487b161a409
https://doi.org/10.1016/s0006-2952(00)00386-5
https://doi.org/10.1016/s0006-2952(00)00386-5
Autor:
A. Rob P. M. Valentijn, Louis H. Cohen, Pascale Nègre-Aminou, Jacques H. van Boom, Mark Overhand, Elsbet J. Pieterman, Rick E.W van Leeuwen, Junrong Du, Gijs A. van der Marel
Publikováno v:
Biochemical Pharmacology. 57:365-373
In this study, it was investigated whether and how inhibitors of protein:farnesyl transferase (PFT) can inhibit the proliferation of human smooth muscle cells (HSMC) in culture. Several farnesyl pyrophosphate (FPP) analogues were synthesized and test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5046b599cd888118b43d1cf2f7410fa2
https://doi.org/10.1016/s0006-2952(98)00322-0
https://doi.org/10.1016/s0006-2952(98)00322-0
Autor:
Rick E.W. Van Leeuwen, Loes Roodenburg, Gijs A. van der Marel, Louis H. Cohen, Adrianus R.P.M. Valentijn, Jacques H. van Boom, Robert J. Lutz, R.Holger Huisman
Publikováno v:
Biochemical Pharmacology. 49:839-845
The inhibitory potency of farnesyl pyrophosphate analogues was investigated on two farnesyl pyrophosphate-consuming enzymes: squalene synthase, a secondary regulation site in the cholesterol synthesis pathway, and protein: farnesyl transferase, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0474b09f9084b081d5a477d7894d9e9f
https://doi.org/10.1016/0006-2952(94)00454-t
https://doi.org/10.1016/0006-2952(94)00454-t
Autor:
Wilfried W. de Jong, Roy A. Quinlan, G.Christa F van Thiel, Paul R.L.A. van den IJssel, Louis H. Cohen, Rick E.W van Leeuwen, Pascale Nègre-Aminou
Publikováno v:
Biochemical pharmacology. 64(10)
In the present study, we have analyzed the response of human smooth muscle cell (SMC)s to oxidative stress, in terms of recruitment of key elements of the stress-activated protein kinase (SAPK) pathway, such as Rac 1 , p38, and the small heat shock p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9959a7ede654999692ff2f2c4f7a2d
https://pubmed.ncbi.nlm.nih.gov/12417261
https://pubmed.ncbi.nlm.nih.gov/12417261
Autor:
Rick E.W van Leeuwen, Pascale Nègre-Aminou, Monique van Erck, Louis H. Cohen, Arlène K. van Vliet, G.Christa F van Thiel
Publikováno v:
Biochimica et biophysica acta. 1345(3)
The effects of 6 HMG-CoA reductase inhibitors: pravastatin, lovastatin, simvastatin, atorvastatin, fluvastatin and cerivastatin were analyzed in cultured human smooth muscle cells, fibroblasts, endothelial cells and myoblasts. In vascular smooth musc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb4d36df8f1642d06e184f22f811581
https://pubmed.ncbi.nlm.nih.gov/9150246
https://pubmed.ncbi.nlm.nih.gov/9150246