Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment.

Autor: Troutman JA; Central Product Safety, The Procter & Gamble Company, Cincinnati, OH, USA. Electronic address: troutman.ja@pg.com., Rick DL; Toxicology & Environmental Research & Consulting, The Dow Chemical Company, Midland, MI, USA. Electronic address: LRick@dow.com., Stuard SB; Central Product Safety, The Procter & Gamble Company, Cincinnati, OH, USA. Electronic address: stuard.sb@pg.com., Fisher J; National Center for Toxicological Research, Food & Drug Administration, Jefferson, AR, USA. Electronic address: jeffrey.fisher@fda.hhs.gov., Bartels MJ; Toxicology & Environmental Research & Consulting, The Dow Chemical Company, Midland, MI, USA. Electronic address: MJBartels@dow.com.

Publikováno v: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2015 Nov; Vol. 73 (2), pp. 530-43. Date of Electronic Publication: 2015 Jul 16.

TK Modeler version 1.0, a Microsoft® Excel®-based modeling software for the prediction of diurnal blood/plasma concentration for toxicokinetic use.

Autor: McCoy AT; Toxicology & Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA. amccoy@dow.com, Bartels MJ, Rick DL, Saghir SA

Publikováno v: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2012 Jul; Vol. 63 (2), pp. 333-43. Date of Electronic Publication: 2012 Apr 13.

Simultaneous quantitation of testosterone and estradiol in human cell line (H295R) by liquid chromatography/positive atmospheric pressure photoionization tandem mass spectrometry.

Autor: Zhang F; Toxicology and Environmental Research & Consulting, The Dow Chemical Company, Midland, MI 48674, USA. fzzhang@dow.com, Rick DL, Kan LH, Perala AW, Geter DR, LeBaron MJ, Bartels MJ

Publikováno v: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2011 Oct 30; Vol. 25 (20), pp. 3123-30.

In vitro metabolism and covalent binding of ethylbenzene to microsomal protein as a possible mechanism of ethylbenzene-induced mouse lung tumorigenesis.

Autor: Saghir SA; Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA. ssaghir@dow.com, Zhang F, Rick DL, Kan L, Bus JS, Bartels MJ

Publikováno v: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2010 Jul-Aug; Vol. 57 (2-3), pp. 129-35. Date of Electronic Publication: 2010 Jan 22.

Mechanism of ethylbenzene-induced mouse-specific lung tumor: metabolism of ethylbenzene by rat, mouse, and human liver and lung microsomes.

Autor: Saghir SA; Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA. ssaghir@dow.com, Rick DL, McClymont EL, Zhang F, Bartels MJ, Bus JS

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2009 Feb; Vol. 107 (2), pp. 352-66. Date of Electronic Publication: 2008 Dec 15.