Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rick D. Gaston"'
Autor:
Melanie Kessler, Eric A. Ertel, John Gatfield, Rick D Gaston, Corinna Grisostomi, Thomas Pfeifer, Lubos Remen, Lloyd Simons, Olivier Bezencon, Johannes Mosbacher, Catherine Roch, Richard Moon, Dennis Michael Downing, Markus Rey
Publikováno v:
Journal of Medicinal Chemistry. 59:8398-8411
A series of dihydropyrazole derivatives was developed as potent, selective, and brain-penetrating T-type calcium channel blockers. An optimized derivative, compound 6c, was advanced to in vivo studies, where it demonstrated efficacy in the WAG/Rij ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1d15b224e97575ffd39760a63e490e
https://doi.org/10.1021/acs.jmedchem.6b00756
https://doi.org/10.1021/acs.jmedchem.6b00756
Autor:
Ruben de Kanter, René Roscher, Rick D Gaston, Benno Schindelholz, John Gatfield, Catherine Roch, Olivier Bezencon, Eric A. Ertel, Johannes Mosbacher, Bruno Capeleto, Luboš Remeň, Davide Pozzi, Lloyd Simons, Thomas Pfeifer, Bibia Heidmann, Isabelle Reymond, Melanie Kessler, Corinna Grisostomi, Dennis Michael Downing, Simon Stamm, Richard Moon, Sylvia Richard, Luca Moccia, Romain Siegrist, Michael Toeroek-Schafroth, Elvire Fournier, Markus Rey
Publikováno v:
CHIMIA, Vol 71, Iss 10 (2017)
We describe the discovery and optimization of new, brain-penetrant T-type calcium channel blockers. We present optimized compounds with excellent efficacy in a rodent model of generalized absence-like epilepsy. Along the fine optimization of a chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7676bf0297b6aa2abe2bed65f09f90d1
https://doi.org/10.2533/chimia.2017.722
https://doi.org/10.2533/chimia.2017.722
Publikováno v:
Tetrahedron Letters. 42:5837-5839
Synthesis of a water-soluble recyclable organostannatrane has been accomplished via a straightforward three-step synthesis. The organostannatrane exhibits excellent water-solubility (0.33 M) and can be recovered from aqueous solutions via removal of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f337eeb9cd86b4f58c5d0516ab65bac
https://doi.org/10.1016/s0040-4039(01)01148-0
https://doi.org/10.1016/s0040-4039(01)01148-0
Publikováno v:
ChemInform. 23
Formyl cyanide has been generated by the retro-ene cleavage of cinnamyloxyacetonitrile using flash vacuum pyrolysis. Isolation of pure formyl cyanide in the gas phase has shown that the compoundis much more stable than originally reported, with a mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::601a2389da89bb31f274b20825942193
https://doi.org/10.1002/chin.199227141
https://doi.org/10.1002/chin.199227141
Publikováno v:
ChemInform. 32
Synthesis of a water-soluble recyclable organostannatrane has been accomplished via a straightforward three-step synthesis. The organostannatrane exhibits excellent water-solubility (0.33 M) and can be recovered from aqueous solutions via removal of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91fa67d12c0049bf4a7393e58077d411
https://doi.org/10.1002/chin.200148138
https://doi.org/10.1002/chin.200148138
Publikováno v:
Journal of the American Chemical Society. 114:1933-1938
Formyl cyanide has been generated by the retro-ene cleavage of cinnamyloxyacetonitrile using flash vacuum pyrolysis. Isolation of pure formyl cyanide in the gas phase has shown that the compoundis much more stable than originally reported, with a mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c6154c9997c42f9d8f1d791fec0d32f
https://doi.org/10.1021/ja00032a001
https://doi.org/10.1021/ja00032a001
Autor:
Bruce Evans, John G. Allen, Matthew P. Bourbeau, Alexander M. Long, Xin Huang, Larry W Mann, Rick D Gaston, Paul S. Andrews, Peter Yakowec, Michael D. Bartberger, Randall W. Hungate, G. Erich Wohlhieter, Tani Ann Lee, Evelyn Yang, Stephen Schneider, Michael E Matison, Robert C. Gadwood, Andreas Reichelt, Klaus Michelsen, Dongyin Yu, Jonathan D. Oliner
Publikováno v:
Journal of medicinal chemistry. 52(22)
Tumor protein 53 (p53) is a critical regulator of cell cycle and apoptosis that is frequently disabled in human tumors. In many tumor types, p53 is deleted or mutated, but in others p53 is inactivated by overexpression or amplification of its negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8874429a3e1b775cb14bfdcd8cc3907f
https://pubmed.ncbi.nlm.nih.gov/19856920
https://pubmed.ncbi.nlm.nih.gov/19856920
Autor:
Przemyslaw A. Marek, S. William Tam, Madhavi G. Murty, Maiko Ezawa, Mark Trocha, L. Gordon Letts, Richard A Earl, Rick D Gaston, Delano V. Young, Subhash P. Khanapure, Xinqin Fang, David S. Garvey, David R. Janero, Allison M. Martino, Matthew J. Shumway
Publikováno v:
Journal of medicinal chemistry. 46(25)
A novel series of benzo-1,3-dioxolane metharyl derivatives was synthesized and evaluated for cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1) inhibition in human whole blood (HWB). In the present study, structure-activity relationships (SAR) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6702dd4fac9e66e1d5b5d40b8b28af16
https://pubmed.ncbi.nlm.nih.gov/14640557
https://pubmed.ncbi.nlm.nih.gov/14640557
Autor:
John G. Allen, Matthew P. Bourbeau, G. Erich Wohlhieter, Michael D. Bartberger, Klaus Michelsen, Randall Hungate, Robert C. Gadwood, Rick D. Gaston, Bruce Evans, Larry W. Mann, Michael E. Matison, Stephen Schneider, Xin Huang, Dongyin Yu, Paul S. Andrews, Andreas Reichelt, Alexander M. Long, Peter Yakowec, Evelyn Y. Yang, Tani Ann Lee
Publikováno v:
Journal of Medicinal Chemistry; Nov2009, Vol. 52 Issue 22, p7044-7053, 10p
Autor:
Gregory A. Hartmann, Rick D. Gaston
Publikováno v:
Journal of Chemical Education. 72:96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66d5f2427e00d9c72318de8d7f4a1fc3
https://doi.org/10.1021/ed072p96
https://doi.org/10.1021/ed072p96