Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rick D Gaston"'
Autor:
Melanie Kessler, Eric A. Ertel, John Gatfield, Rick D Gaston, Corinna Grisostomi, Thomas Pfeifer, Lubos Remen, Lloyd Simons, Olivier Bezencon, Johannes Mosbacher, Catherine Roch, Richard Moon, Dennis Michael Downing, Markus Rey
Publikováno v:
Journal of Medicinal Chemistry. 59:8398-8411
A series of dihydropyrazole derivatives was developed as potent, selective, and brain-penetrating T-type calcium channel blockers. An optimized derivative, compound 6c, was advanced to in vivo studies, where it demonstrated efficacy in the WAG/Rij ra
Publikováno v:
ChemInform. 23
Formyl cyanide has been generated by the retro-ene cleavage of cinnamyloxyacetonitrile using flash vacuum pyrolysis. Isolation of pure formyl cyanide in the gas phase has shown that the compoundis much more stable than originally reported, with a mea
Publikováno v:
Journal of the American Chemical Society. 114:1933-1938
Formyl cyanide has been generated by the retro-ene cleavage of cinnamyloxyacetonitrile using flash vacuum pyrolysis. Isolation of pure formyl cyanide in the gas phase has shown that the compoundis much more stable than originally reported, with a mea
Autor:
Przemyslaw A. Marek, S. William Tam, Madhavi G. Murty, Maiko Ezawa, Mark Trocha, L. Gordon Letts, Richard A Earl, Rick D Gaston, Delano V. Young, Subhash P. Khanapure, Xinqin Fang, David S. Garvey, David R. Janero, Allison M. Martino, Matthew J. Shumway
Publikováno v:
Journal of medicinal chemistry. 46(25)
A novel series of benzo-1,3-dioxolane metharyl derivatives was synthesized and evaluated for cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1) inhibition in human whole blood (HWB). In the present study, structure-activity relationships (SAR) in
Autor:
John G. Allen, Matthew P. Bourbeau, G. Erich Wohlhieter, Michael D. Bartberger, Klaus Michelsen, Randall Hungate, Robert C. Gadwood, Rick D. Gaston, Bruce Evans, Larry W. Mann, Michael E. Matison, Stephen Schneider, Xin Huang, Dongyin Yu, Paul S. Andrews, Andreas Reichelt, Alexander M. Long, Peter Yakowec, Evelyn Y. Yang, Tani Ann Lee
Publikováno v:
Journal of Medicinal Chemistry; Nov2009, Vol. 52 Issue 22, p7044-7053, 10p
Autor:
Gregory A. Hartmann, Rick D. Gaston
Publikováno v:
Journal of Chemical Education. 72:96