Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rick Crouse"'
Autor:
Kevin Sill, J. Edward Semple, Tomas Vojkovsky, Suzanne Bakewell, Lauren Repp, Tyler Ellis, Rick Crouse, Tara Lee Costich, Adam Carie, Taylor Buley
Publikováno v:
Cancer Research. 76:1317-1317
Daunorubicin is an anthracycline family chemotherapeutic with a narrow therapeutic window. Employing our nanoparticle drug delivery platform we encapsulated daunorubicin non-covalently in the hydrophobic core of a polymer micelle (IT-143). IT-143 is
Autor:
Adam Carie, Kevin Sill, Suzanne Bakewell, J. Edward Semple, Bradford Sullivan, Rick Crouse, Jyothi Sethuraman, Tara Lee Costich, Tyler Ellis, Taylor Buley
Publikováno v:
Cancer Research. 76:1321-1321
IT-147 is a formulation of epothilone D encapsulated in a stabilized polymer micelle. Epothilones are a class of cytotoxic chemotherapeutics that induce apoptosis via microtubule stabilization. Epothilone D is a poor substrate for P-glycoprotein effl
Publikováno v:
Cancer Research. 76:284-284
IT-139, sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] is a ruthenium based small molecule that has successfully completed a phase I clinical trial in 41 patients with mild to moderate systemic toxicities. There were no dose limiting hemato
Autor:
Tomas Vojkovsky, Rick Crouse, Jyothi Sethuraman, Tara Lee Costich, Suzanne Bakewell, Valentin Cognet
Publikováno v:
Cancer Research. 76:2996-2996
IT-139, sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] is a first in class small molecule that has successfully completed a phase I clinical trial against solid refractory cancers. 11 of 41 patients achieved stable disease with manageable s