Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rick Carty"'
Autor:
Garth A. Kinberger, Michael Tanowitz, Linda Fradkin, Michael E. Østergaard, Alfred E. Chappell, Jinghua Yu, Richard G. Lee, Michaela Jackson, Sue Murray, Amy Dan, Frank Rigo, C. Frank Bennett, Patrick Anderson, Tae-Won Kim, Rick Carty, Adam E. Mullick, Hans Gaus, Eric E. Swayze, Audrey Low, Thazha P. Prakash, Punit P. Seth, Rachel Q Peralta
Publikováno v:
Nucleic Acids Research
We determined the effect of attaching palmitate, tocopherol or cholesterol to PS ASOs and their effects on plasma protein binding and on enhancing ASO potency in the muscle of rodents and monkeys. We found that cholesterol ASO conjugates showed 5-fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb973fd64884350316c0896910ce938
http://europepmc.org/articles/PMC6614849
http://europepmc.org/articles/PMC6614849
Autor:
Shuling Guo, Sheri L. Booten, Walt F. Lima, Mark J. Graham, Susan F. Murray, Heather F. Murray, Stan Riney, Alfred E. Chappell, Hans Gaus, Jeff Crosby, Mariam Aghajan, Chenguang Zhao, Audrey Low, Rick Carty, Thazha P. Prakash, Punit P. Seth, Brett P. Monia, Karsten Schmidt, Eric E. Swayze, Jinghua Yu
Publikováno v:
Nucleic Acids Research
Triantennary N-acetyl galactosamine (GalNAc, GN3), a high-affinity ligand for the hepatocyte-specific asialoglycoprotein receptor (ASGPR), enhances the potency of second-generation gapmer antisense oligonucleotides (ASOs) 6–10-fold in mouse liver.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75aee5c2accb348ceaacf9fe6aae89ff
https://doi.org/10.1093/nar/gku531
https://doi.org/10.1093/nar/gku531