Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Rick A Wetsel"'
Autor:
Yanyu Wang, Sarah A Jenkins, Chunfang Gu, Ankita Shree, Margarita Martinez-Moczygemba, Jennifer Herold, Marina Botto, Rick A Wetsel, Yi Xu
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007579 (2019)
[This corrects the article DOI: 10.1371/journal.ppat.1005678.].
Externí odkaz:
https://doaj.org/article/0d71b0984a7f464680f0f269e18b7eb5
Autor:
Yanyu Wang, Sarah A Jenkins, Chunfang Gu, Ankita Shree, Margarita Martinez-Moczygemba, Jennifer Herold, Marina Botto, Rick A Wetsel, Yi Xu
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005968 (2016)
[This corrects the article DOI: 10.1371/journal.ppat.1005678.].
Externí odkaz:
https://doaj.org/article/c256971a77bd49078c2ef3b9ae9ff379
Autor:
Yanyu Wang, Sarah A Jenkins, Chunfang Gu, Ankita Shree, Margarita Martinez-Moczygemba, Jennifer Herold, Marina Botto, Rick A Wetsel, Yi Xu
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005678 (2016)
Spores of Bacillus anthracis, the causative agent of anthrax, are known to persist in the host lungs for prolonged periods of time, however the underlying mechanism is poorly understood. In this study, we demonstrated that BclA, a major surface prote
Externí odkaz:
https://doaj.org/article/40555b242b6d42bdb8d76604a7c0de0e
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120294 (2015)
BXD2 mice spontaneously develop autoantibodies and subsequent glomerulonephritis, offering a useful animal model to study autoimmune lupus. Although initial studies showed a critical contribution of IL-17 and Th17 cells in mediating autoimmune B cell
Externí odkaz:
https://doaj.org/article/261b13f971044da39a23c9ad800b5c46
Autor:
Elisabeth Wende, Robert Laudeley, André Bleich, Eva Bleich, Rick A Wetsel, Silke Glage, Andreas Klos
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62257 (2013)
Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying pathomechanisms in order to identify new therapeutic targets. Complement activation was found in patien
Externí odkaz:
https://doaj.org/article/d1c9b939d4ec46ceb9c7d504ecbd252c
Autor:
Hoyong Lim, Young Uk Kim, Scott M Drouin, Stacey Mueller-Ortiz, Kyoungah Yun, Eva Morschl, Rick A Wetsel, Yeonseok Chung
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52666 (2012)
Activation of complement is one of the earliest immune responses to exogenous threats, resulting in various cleavage products including anaphylatoxin C3a. In addition to its contribution to host defense, C3a has been shown to mediate Th2 responses in
Externí odkaz:
https://doaj.org/article/dbe108bd87454309b3ec1fa81169d059
Autor:
Damien Bierschenk, Nikolina Papac-Milicevic, Ian P. Bresch, Valentina Kovacic, Serena Bettoni, Mateusz Dziedzic, Rick A. Wetsel, Susanne Eschenburg, Christoph J. Binder, Anna M. Blom, Ben C. King
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Dysregulated NLRP3 inflammasome activation drives a wide variety of diseases, while endogenous inhibition of this pathway is poorly characterised. The serum protein C4b-binding protein (C4BP) is a well-established inhibitor of complement with emergin
Externí odkaz:
https://doaj.org/article/99cd06018276418c8529742dbe8a4176
Publikováno v:
The FASEB Journal. 34:7540-7560
The vascular endothelium has been discovered in the past several years to be important in shaping the cellular immune response. During the immune response the vascular endothelium is constantly perturbed by biologically potent molecules, including th
Autor:
Ken Simmons, Rick A. Wetsel, Charles A. Garcia, Stacey L. Mueller-Ortiz, John L. Mazzilli, Aleksey Y. Domozhirov, Eva M Zsigmond
Publikováno v:
Molecular Immunology. 118:91-98
The purpose of this study was to identify a membrane-bound complement inhibitor that could be overexpressed on retinal pigment epithelial cells (RPE) providing a potential therapy for age-related macular degeneration (AMD). This type of therapy may a
Autor:
Aleksey Y. Domozhirov, Charles A. Garcia, Peter D. Westenskow, Ken Simmons, John L. Mazzilli, Joshua D Snook, Eva M Zsigmond, Rick A. Wetsel
Publikováno v:
J Ocul Pharmacol Ther
Purpose: Age-related macular degeneration (AMD) is a common disease trending towards epidemic proportions and is a leading cause of irreversible vision loss in people over the age of 65. A pathomechanism of AMD is death and/or dysfunction of retinal