Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Rick A Friedman"'
Autor:
Ely Cheikh Boussaty, Yuzuru Ninoyu, Leonardo R Andrade, Qingzhong Li, Ryu Takeya, Hideki Sumimoto, Takahiro Ohyama, Karl J Wahlin, Uri Manor, Rick A Friedman
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011211 (2024)
Age-related hearing loss (ARHL) is a common sensory impairment with complex underlying mechanisms. In our previous study, we performed a meta-analysis of genome-wide association studies (GWAS) in mice and identified a novel locus on chromosome 18 ass
Externí odkaz:
https://doaj.org/article/ac94d3baa66a4707867124f7352245ec
Autor:
Pezhman Salehi, Marshall X Ge, Usha Gundimeda, Leah Michelle Baum, Homero Lael Cantu, Joel Lavinsky, Litao Tao, Anthony Myint, Charlene Cruz, Juemei Wang, Angeliki Maria Nikolakopoulou, Carolina Abdala, Matthew William Kelley, Takahiro Ohyama, Thomas Matthew Coate, Rick A Friedman
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007048 (2017)
Neuropilin-1 (Nrp1) encodes the transmembrane cellular receptor neuropilin-1, which is associated with cardiovascular and neuronal development and was within the peak SNP interval on chromosome 8 in our prior GWAS study on age-related hearing loss (A
Externí odkaz:
https://doaj.org/article/197dc0aae6f442fc9fbd254a8ce05297
Autor:
Joel Lavinsky, Amanda L Crow, Calvin Pan, Juemei Wang, Ksenia A Aaron, Maria K Ho, Qingzhong Li, Pehzman Salehide, Anthony Myint, Maya Monges-Hernadez, Eleazar Eskin, Hooman Allayee, Aldons J Lusis, Rick A Friedman
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005293 (2015)
Externí odkaz:
https://doaj.org/article/dd1c3b2e0dbb46a3a70a3faffb50ba27
Autor:
Joel Lavinsky, Amanda L Crow, Calvin Pan, Juemei Wang, Ksenia A Aaron, Maria K Ho, Qingzhong Li, Pehzman Salehide, Anthony Myint, Maya Monges-Hernadez, Eleazar Eskin, Hooman Allayee, Aldons J Lusis, Rick A Friedman
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005094 (2015)
In the United States, roughly 10% of the population is exposed daily to hazardous levels of noise in the workplace. Twin studies estimate heritability for noise-induced hearing loss (NIHL) of approximately 36%, and strain specific variation in sensit
Externí odkaz:
https://doaj.org/article/94782504ad8043708b393a68af904bc6
Volumetric analysis of the aging auditory pathway using high resolution magnetic resonance histology
Autor:
Eric Y. Du, Briana K. Ortega, Yuzuru Ninoyu, Robert W. Williams, Gary P. Cofer, James J. Cook, Kathryn J. Hornburg, Yi Qi, G. Allan Johnson, Rick A. Friedman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Numerous shown consequences of age-related hearing loss have been unveiled; however, the relationship of the cortical and subcortical structures of the auditory pathway with aging is not well known. Investigations into neural structure analysis remai
Externí odkaz:
https://doaj.org/article/6a8811bcadb44f6385348548acc67a51
Autor:
Miguel A. Ramirez, Yuzuru Ninoyu, Cayla Miller, Leonardo R. Andrade, Seby Edassery, Ewa Bomba-Warczak, Briana Ortega, Uri Manor, Mark A. Rutherford, Rick A. Friedman, Jeffrey N. Savas
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104803- (2022)
Summary: Hearing depends on precise synaptic transmission between cochlear inner hair cells and spiral ganglion neurons through afferent ribbon synapses.Neuroligins (Nlgns) facilitate synapse maturation in the brain, but they have gone unstudied in t
Externí odkaz:
https://doaj.org/article/2d83c1d5d98a4ed9a50479488748c93e
Publikováno v:
Otolaryngologic Clinics of North America. 56:533-541
Autor:
Tammy B. Pham, Ely Cheikh Boussaty, Antonio Currais, Pamela Maher, David R. Schubert, Uri Manor, Rick A. Friedman
Publikováno v:
Journal of Molecular Neuroscience. 73:307-315
In the senescence-accelerated mouse prone 8 (SAMP8) mouse model, oxidative stress leads to premature senescence and age-related hearing impairment (ARHI). CMS121 inhibits oxytosis/ferroptosis by targeting fatty acid synthase. The aim of our study was
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss
Autor:
Limei Cui, Jing Zheng, Qiong Zhao, Jia-Rong Chen, Hanqing Liu, Guanghua Peng, Yue Wu, Chao Chen, Qiufen He, Haosong Shi, Shankai Yin, Rick A. Friedman, Ye Chen, Min-Xin Guan
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
The pathophysiology underlying spiral ganglion cell defect–induced deafness remains elusive. Using the whole exome sequencing approach, in combination with functional assays and a mouse disease model, we identified the potentially novel deafness-ca
Externí odkaz:
https://doaj.org/article/d7b9609d77224c7ba5b56f7c0d1119f2
Autor:
Peter R, Dixon, Luke, Wojdyla, Joshua, Lee, Omid, Moshtaghi, Alexander D, Claussen, Usman A, Khan, Marin A, Mcdonald, Marc S, Schwartz, Rick A, Friedman
Publikováno v:
Otology & Neurotology. 43:1072-1077
Predict hearing preservation after middle cranial fossa approach for vestibular schwannomas.Application of machine learning algorithms, including classification and regression trees and random forest models to observational data.Single-tertiary refer