Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Rick A, Friedman"'
Autor:
Kathleen M. Fisch, Sara Brin Rosenthal, Adam Mark, Roman Sasik, Chanond A. Nasamran, Royce Clifford, M. Jennifer Derebery, Ely Boussaty, Kristen Jepsen, Jeffrey Harris, Rick A. Friedman
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Ménière's disease (MD) is a disorder of the inner ear that causes episodic bouts of severe dizziness, roaring tinnitus, and fluctuating hearing loss. To date, no targeted therapy exists. As such, we have undertaken a large whole
Externí odkaz:
https://doaj.org/article/8da97123b0944854b490b79a85cae0b7
Autor:
Ely Cheikh Boussaty, Yuzuru Ninoyu, Leonardo R Andrade, Qingzhong Li, Ryu Takeya, Hideki Sumimoto, Takahiro Ohyama, Karl J Wahlin, Uri Manor, Rick A Friedman
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011211 (2024)
Age-related hearing loss (ARHL) is a common sensory impairment with complex underlying mechanisms. In our previous study, we performed a meta-analysis of genome-wide association studies (GWAS) in mice and identified a novel locus on chromosome 18 ass
Externí odkaz:
https://doaj.org/article/ac94d3baa66a4707867124f7352245ec
Autor:
Robert C. Rennert, Michael G. Brandel, Jeffrey A. Steinberg, Rick A. Friedman, William T. Couldwell, Takanori Fukushima, John D. Day, Alexander A. Khalessi, Michael L. Levy
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Anatomic knowledge of the internal auditory canal (IAC) and surrounding structures is a prerequisite for performing skull base approaches to the IAC. We herein perform a morphometric analysis of the IAC and surgically relevant aspects of the
Externí odkaz:
https://doaj.org/article/e5b44819a0e9439d9cfe8f5d9a6f9bba
Volumetric analysis of the aging auditory pathway using high resolution magnetic resonance histology
Autor:
Eric Y. Du, Briana K. Ortega, Yuzuru Ninoyu, Robert W. Williams, Gary P. Cofer, James J. Cook, Kathryn J. Hornburg, Yi Qi, G. Allan Johnson, Rick A. Friedman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Numerous shown consequences of age-related hearing loss have been unveiled; however, the relationship of the cortical and subcortical structures of the auditory pathway with aging is not well known. Investigations into neural structure analysis remai
Externí odkaz:
https://doaj.org/article/6a8811bcadb44f6385348548acc67a51
Autor:
Miguel A. Ramirez, Yuzuru Ninoyu, Cayla Miller, Leonardo R. Andrade, Seby Edassery, Ewa Bomba-Warczak, Briana Ortega, Uri Manor, Mark A. Rutherford, Rick A. Friedman, Jeffrey N. Savas
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104803- (2022)
Summary: Hearing depends on precise synaptic transmission between cochlear inner hair cells and spiral ganglion neurons through afferent ribbon synapses.Neuroligins (Nlgns) facilitate synapse maturation in the brain, but they have gone unstudied in t
Externí odkaz:
https://doaj.org/article/2d83c1d5d98a4ed9a50479488748c93e
Local Tumor Behavior Associated With Survival Among Patients With Paraganglioma of the Head and Neck
Autor:
Randall J. Harley, Jason H. Lee MD, Benjamin T. Ostrander MD, Andrey Finegersh MD, Tammy B. Pham MD, Kareem O. Tawfik MD, Yin Ren MD, PhD, Farhoud Faraji MD, PhD, Rick A. Friedman MD, PhD
Publikováno v:
OTO Open, Vol 6 (2022)
Objective The purpose of this study was to evaluate the utility of ICD-O-3 –classified local tumor behavior as a prognosticator of head and neck paraganglioma (HNP) outcomes. Study Design Retrospective cohort study. Setting National Cancer Database
Externí odkaz:
https://doaj.org/article/5ba25133c32c46e2b10e9a909af6fe69
Publikováno v:
Otolaryngologic Clinics of North America. 56:533-541
Autor:
Tammy B. Pham, Ely Cheikh Boussaty, Antonio Currais, Pamela Maher, David R. Schubert, Uri Manor, Rick A. Friedman
Publikováno v:
Journal of Molecular Neuroscience. 73:307-315
In the senescence-accelerated mouse prone 8 (SAMP8) mouse model, oxidative stress leads to premature senescence and age-related hearing impairment (ARHI). CMS121 inhibits oxytosis/ferroptosis by targeting fatty acid synthase. The aim of our study was
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss
Autor:
Limei Cui, Jing Zheng, Qiong Zhao, Jia-Rong Chen, Hanqing Liu, Guanghua Peng, Yue Wu, Chao Chen, Qiufen He, Haosong Shi, Shankai Yin, Rick A. Friedman, Ye Chen, Min-Xin Guan
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
The pathophysiology underlying spiral ganglion cell defect–induced deafness remains elusive. Using the whole exome sequencing approach, in combination with functional assays and a mouse disease model, we identified the potentially novel deafness-ca
Externí odkaz:
https://doaj.org/article/d7b9609d77224c7ba5b56f7c0d1119f2
Autor:
Elina Kari, Lorida Llaci, John L. Go, Marcus Naymik, James A. Knowles, Suzanne M. Leal, Sampath Rangasamy, Matthew J. Huentelman, Rick A. Friedman, Isabelle Schrauwen
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 12, Pp n/a-n/a (2019)
Abstract Background Childhood hearing impairment affects language and cognitive development. Profound congenital sensorineural hearing impairment can be due to an abnormal cochleovestibular nerve (CVN) and cochleovestibular malformations, however, th
Externí odkaz:
https://doaj.org/article/9b80457c15074a4ebf1c72b9e4f78736