Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rick, Oerlemans"'
Autor:
Victor O. Gawriljuk, Andre S. Godoy, Rick Oerlemans, Luise A. T. Welker, Anna K. H. Hirsch, Matthew R. Groves
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Plasmodium falciparum is the main causative agent of malaria, a deadly disease that mainly affects children under five years old. Artemisinin-based combination therapies have been pivotal in controlling the disease, but resistance has arisen
Externí odkaz:
https://doaj.org/article/90554e6626e14b1aa94660f22c07e76b
Autor:
Robin M. Gierse, Rick Oerlemans, Eswar R. Reddem, Victor O. Gawriljuk, Alaa Alhayek, Dominik Baitinger, Harald Jakobi, Bernd Laber, Gudrun Lange, Anna K. H. Hirsch, Matthew R. Groves
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The development of drug resistance by Mycobacterium tuberculosis and other pathogenic bacteria emphasizes the need for new antibiotics. Unlike animals, most bacteria synthesize isoprenoid precursors through the MEP pathway. 1-Deoxy-d-xylulos
Externí odkaz:
https://doaj.org/article/2b8bfdc100064a6dbd3b456cb371d4e2
Autor:
Mikhail S. Chesnokov, Marianna Halasi, Soheila Borhani, Zarema Arbieva, Binal N. Shah, Rick Oerlemans, Irum Khan, Carlos J. Camacho, Andrei L. Gartel
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-13 (2021)
Abstract FOXM1 transcription factor is an oncogene and a master regulator of chemoresistance in multiple cancers. Pharmacological inhibition of FOXM1 is a promising approach but has proven to be challenging. We performed a network-centric transcripto
Externí odkaz:
https://doaj.org/article/3babdd7ba88c4a3193ab9166ae0d1cb3
Autor:
Victor Oliveira Gawriljuk, Rick Oerlemans, Robin M. Gierse, Riya Jotwani, Anna K. H. Hirsch, Matthew R. Groves
Publikováno v:
Crystals, Vol 13, Iss 5, p 737 (2023)
Stagnation in the development of new antibiotics emphasizes the need for the discovery of drugs with novel modes of action that can tackle antibiotic resistance. Contrary to humans, most bacteria use the methylerythritol phosphate (MEP) pathway to sy
Externí odkaz:
https://doaj.org/article/d0c31101d36c42e5a1d40f6228cd1a04
Autor:
Yue Zhang, Huijie Chen, Mengmeng Zou, Rick Oerlemans, Changhao Shao, Yudong Ren, Ruili Zhang, Xiaodan Huang, Guangxing Li, Yingying Cong
Publikováno v:
Viruses, Vol 13, Iss 9, p 1825 (2021)
The porcine epidemic diarrhea virus (PEDV) is an Alphacoronavirus (α-CoV) that causes high mortality in infected piglets, resulting in serious economic losses in the farming industry. Hypericin is a dianthrone compound that has been shown as an anti
Externí odkaz:
https://doaj.org/article/49bd8419c8104e0e86e27e79b75d8b86
Autor:
Nika Sokolova, Lili Zhang, Sadaf Deravi, Rick Oerlemans, Matthew R. Groves, Kristina Haslinger
Publikováno v:
ChemBioChem, 24(9):e202300076. WILEY-V C H VERLAG GMBH
ChemBioChem
ChemBioChem
Oxygen-directed methylation is a ubiquitous tailoring reaction in natural product pathways catalysed by 15 O-methyltransferases (OMTs). Promiscuous OMT biocatalysts are thus a valuable asset in the toolkit for 16 sustainable synthesis and optimizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd1998bb07fa65f16e39c24801eba77
https://research.rug.nl/en/publications/ec746f20-0328-4613-8c53-7d34e424406f
https://research.rug.nl/en/publications/ec746f20-0328-4613-8c53-7d34e424406f
Autor:
Bo Peng, Lili Zhang, Siqi He, Rick Oerlemans, Wim J. Quax, Matthew R. Groves, Kristina Haslinger
Homoeriodictyol and hesperetin are naturally occurring O-methylated flavonoids with many health-promoting properties. They are produced in plants in low abundance and as complex mixtures of similar compounds that are difficult to separate. Synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90fd285741124118d0f5a61133d07af
https://doi.org/10.1101/2022.10.02.510496
https://doi.org/10.1101/2022.10.02.510496
Autor:
Deniz Eris, Pravin Patil, Matthew Groves, M. Sharpe, Meitian Wang, Mojgan Hadian, Rick Oerlemans, Alexander Dömling, Shabnam Shaabani, Fandi Sutanto
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International ed. in English), 60(33), 18231-18239. WILEY-V C H VERLAG GMBH
Angewandte Chemie (International ed. in English), 60(33), 18231-18239. WILEY-V C H VERLAG GMBH
Protein crystallography (PX) is widely used to drive advanced stages of drug optimization or to discover medicinal chemistry starting points by fragment soaking. However, recent progress in PX could allow for a more integrated role into early drug di
Autor:
Irum Khan, Soheila Borhani, Marianna Halasi, Carlos J. Camacho, Zarema Arbieva, Binal N. Shah, Andrei L. Gartel, Mikhail S. Chesnokov, Rick Oerlemans
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
FOXM1 transcription factor is an oncogene and a master regulator of chemoresistance in multiple cancers. Pharmacological inhibition of FOXM1 is a promising approach but has proven to be challenging. We performed a network-centric transcriptomic analy
Publikováno v:
Drug Repurposing-Molecular Aspects and Therapeutic Applications
Since the advent of the twentieth century, several severe virus outbreaks have occurred—H1N1 (1918), H2N2 (1957), H3N2 (1968), H1N1 (2009) and recently COVID-19 (2019)—all of which have posed serious challenges to public health. Therefore, rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb03e847e51284d44315a7109f3742d
https://doi.org/10.5772/intechopen.101443
https://doi.org/10.5772/intechopen.101443