Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rick, Mofsen"'
Autor:
Daniel Umbricht, Markus Abt, Paul Tamburri, Christopher Chatham, Štefan Holiga, Michael J. Frank, Anne G.E. Collins, David P. Walling, Rick Mofsen, Daniel Gruener, Lev Gertsik, Jeff Sevigny, Sanjay Keswani, Juergen Dukart
Publikováno v:
Biological Psychiatry Global Open Science, Vol 1, Iss 1, Pp 70-77 (2021)
Background: Reduced activation of dopamine D1 receptor signaling may be implicated in reward functioning as a potential driver of negative symptoms in schizophrenia. Phosphodiesterase 10A (PDE10A), an enzyme that is highly expressed in the striatum,
Externí odkaz:
https://doaj.org/article/4e96e9575d7248e086f19bdc0d374f88
Autor:
Stefan Holiga, Daniel Umbricht, Rick Mofsen, Markus Abt, Michael J. Frank, Juergen Dukart, Sanjay Keswani, Lev Gertsik, Christopher H. Chatham, Daniel Gruener, Jeff Sevigny, Anne G.E. Collins, David P. Walling, Paul Tamburri
Publikováno v:
Biological psychiatry 1(1), 70-77 (2021). doi:10.1016/j.bpsgos.2021.03.001
Biological Psychiatry Global Open Science, Vol 1, Iss 1, Pp 70-77 (2021)
Biological Psychiatry Global Open Science, Vol 1, Iss 1, Pp 70-77 (2021)
Background Reduced activation of dopamine D1 receptor signaling may be implicated in reward functioning as a potential driver of negative symptoms in schizophrenia. Phosphodiesterase 10A (PDE10A), an enzyme that is highly expressed in the striatum, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055794a1effef60fcc6fd99358a3cd1d
https://hdl.handle.net/2128/28586
https://hdl.handle.net/2128/28586
Autor:
Rick Mofsen, Lev Gertsik, Jürgen Dukart, Michael J. Frank, Daniel Umbricht, Anne G.E. Collins, Daniel Gruener, Paul Tamburri, David P. Walling, Christopher H. Chatham, Markus Abt, Jeffrey Sevigny
Publikováno v:
Schizophrenia Bulletin
Background The enzyme phosphodiesterase 10A (PDE10A) is highly expressed in the striatum where it modulates both dopamine D2 and D1 dependent signaling. Its inhibition leads to a suppression of D2 mediated signaling –similar to effects of D2 antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756d2971653124d4957974f8624795d4
http://europepmc.org/articles/PMC5888501
http://europepmc.org/articles/PMC5888501
Autor:
Sheldon, Preskorn, Matthew, Macaluso, D O Vishaal, Mehra, Gary, Zammit, Joseph R, Moskal, Ronald M, Burch, Rick, Mofsen
Publikováno v:
Journal of psychiatric practice. 21(2)
Approximately 45% of patients with major depressive disorder (MDD) do not remit when treated with biogenic amine antidepressants. Consequently, there is a significant need for antidepressant agents with different mechanisms of action. Early proof of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126b36593df8f87b8d4f37d3973e541c
https://pubmed.ncbi.nlm.nih.gov/25782764
https://pubmed.ncbi.nlm.nih.gov/25782764
Publikováno v:
The International Journal of Psychiatry in Medicine. 34:259-266
Background:As evidence of a biologic determinant of schizophrenia has been elaborated, an interest in the relationship between schizophrenia and autoimmune disorders has become increasingly more developed over the last decade. Pedigree analysis has s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5635c56915a13879a381099d4ccf9b26
https://doi.org/10.2190/v8jb-5m7q-l5xu-xr2a
https://doi.org/10.2190/v8jb-5m7q-l5xu-xr2a
Autor:
Rick Mofsen, Jordan Balter
Publikováno v:
Clinical therapeutics. 23(10)
Background: The use of generic drugs has resulted in considerable cost savings; however, whether all generics are truly bioequivalent to their brand-name counterparts is questionable. Although the efficacy of clozapine in the management of treatment-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95341fbf2fabe683e857492c938e8df
https://pubmed.ncbi.nlm.nih.gov/11726006
https://pubmed.ncbi.nlm.nih.gov/11726006