Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Rick, Havinga"'
Autor:
Hannah R. Wardill, Ana Rita Da Silva Ferreira, Himanshu Kumar, Emma H. Bateman, Courtney B. Cross, Joanne M. Bowen, Rick Havinga, Hermie J. M. Harmsen, Jan Knol, Bram Dorresteijn, Miriam van Dijk, Jeroen van Bergenhenegouwen, Wim J. E. Tissing
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-11 (2023)
Abstract Cytotoxicity (i.e. cell death) is the core mechanism by which chemotherapy induces its anti-cancer effects. Unfortunately, this same mechanism underpins the collateral damage it causes to healthy tissues. The gastrointestinal tract is highly
Externí odkaz:
https://doaj.org/article/482db40cb7d744d09d27ea7752343e9d
Autor:
Venetia Bazioti, Anouk M. La Rose, Sjors Maassen, Frans Bianchi, Rinse de Boer, Benedek Halmos, Deepti Dabral, Emma Guilbaud, Arthur Flohr-Svendsen, Anouk G. Groenen, Alejandro Marmolejo-Garza, Mirjam H. Koster, Niels J. Kloosterhuis, Rick Havinga, Alle T. Pranger, Miriam Langelaar-Makkinje, Alain de Bruin, Bart van de Sluis, Alison B. Kohan, Laurent Yvan-Charvet, Geert van den Bogaart, Marit Westerterp
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Cholesterol efflux is mediated by specific transporters in T cells. Here the authors show that when the ABCA1/ABCG1 cholesterol transporters are absent, peripheral T cell numbers are reduced but activation increased with a premature aging phenotype o
Externí odkaz:
https://doaj.org/article/cce4b1448a8b440488b90cdc27f0a71a
Autor:
Anna Palmiotti, Hilde D. de Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Esther Verkade, Melany K. Veentjer, Theo H. van Dijk, Vincent W. Bloks, Rick Havinga, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2495 (2023)
Bile acids (BAs) and their signaling pathways have been identified as therapeutic targets for liver and metabolic diseases. We generated Cyp2c70−/− (KO) mice that were not able to convert chenodeoxycholic acid into rodent-specific muricholic acid
Externí odkaz:
https://doaj.org/article/6f2bbd3a48534fe2b250f2e7649963fb
Autor:
Lori W. E. van der Schoor, Henkjan J. Verkade, Anna Bertolini, Sanne de Wit, Elvira Mennillo, Eva Rettenmeier, André A. Weber, Rick Havinga, Petra Valášková, Jana Jašprová, Dicky Struik, Vincent W. Bloks, Shujuan Chen, Andrea B. Schreuder, Libor Vítek, Robert H. Tukey, Johan W. Jonker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Neonatal hyperbilirubinemia or jaundice is associated with kernicterus, resulting in permanent neurological damage or even death. Conventional phototherapy does not prevent hyperbilirubinemia or eliminate the need for exchange transfusion. H
Externí odkaz:
https://doaj.org/article/59f5708413df43f992dcb9093f632208
Autor:
Anouk M. La Rose, Anouk G. Groenen, Benedek Halmos, Venetia Bazioti, Martijn G.S. Rutten, Kishore A. Krishnamurthy, Mirjam H. Koster, Niels J. Kloosterhuis, Marieke Smit, Rick Havinga, Gilles Mithieux, Fabienne Rajas, Folkert Kuipers, Maaike H. Oosterveer, Marit Westerterp
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 31, Iss , Pp 100872- (2022)
Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resemb
Externí odkaz:
https://doaj.org/article/a17931b37180404cb8818baa30ee324c
Autor:
Andries Heida, Nanda Gruben, Leen Catrysse, Martijn Koehorst, Mirjam Koster, Niels J. Kloosterhuis, Albert Gerding, Rick Havinga, Vincent W. Bloks, Laura Bongiovanni, Justina C. Wolters, Theo van Dijk, Geert van Loo, Alain de Bruin, Folkert Kuipers, Debby P.Y. Koonen, Bart van de Sluis
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101349- (2021)
Objective: Obesity-related chronic inflammation plays an important role in the development of Metabolic Associated Fatty Liver Disease (MAFLD). Although the contribution of the pro-inflammatory NF-κB signaling pathway to the progression from simple
Externí odkaz:
https://doaj.org/article/54c1ebb08d38492b9a76c2c3c92de6e6
Autor:
John P. Kennelly, Jelske N. van der Veen, Randal C. Nelson, Kelly-Ann Leonard, Rick Havinga, Jean Buteau, Folkert Kuipers, René L. Jacobs
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1695-1708 (2018)
De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-α (CTα) is required for VLDL secretion. To determine the precise role of de novo PC synthesis in intestinal lipid metabolism, we deleted CTα exclusively in the
Externí odkaz:
https://doaj.org/article/92c736a4f02e47748548008985011563
Autor:
Onne A H O Ronda, Bert J M van de Heijning, Alain de Bruin, Rachel E Thomas, Ingrid Martini, Martijn Koehorst, Albert Gerding, Mirjam H Koster, Vincent W Bloks, Angelika Jurdzinski, Niels L Mulder, Rick Havinga, Eline M van der Beek, Dirk-Jan Reijngoud, Folkert Kuipers, Henkjan J Verkade
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0232069 (2020)
Mouse models are frequently used to study mechanisms of human diseases. Recently, we observed a spontaneous bimodal variation in liver weight in C57BL/6JOlaHsd mice fed a semisynthetic diet. We now characterized the spontaneous variation in liver wei
Externí odkaz:
https://doaj.org/article/7a34a45721614e4783dbcd572ecf0fb3
Autor:
Andrea C. Postmus, Janine K. Kruit, Roos E. Eilers, Rick Havinga, Mirjam H. Koster, Yoshikazu Johmura, Makoto Nakanishi, Bart van de Sluis, Johan W. Jonker
Publikováno v:
Toxicology and Applied Pharmacology. 468
Cancer survivors who received chemotherapy, such as the anthracycline doxorubicin (DOX), have an increased risk of developing complications later in life, including the development of chronic metabolic diseases. Although the etiology of this increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8711e2b18ac3119e7e4ea289730001a
https://doi.org/10.1016/j.taap.2023.116531
https://doi.org/10.1016/j.taap.2023.116531
Autor:
Angela J. C. Tol, Kaja Hribar, Janine Kruit, Laura Bongiovanni, Marcel A. Vieira‐Lara, Mirjam H. Koster, Niels J. Kloosterhuis, Rick Havinga, Martijn Koehorst, Alain de Bruin, Barbara M. Bakker, Maaike H. Oosterveer, Eline M. van der Beek
Publikováno v:
Journal of Physiology, 601(10), 1761-1780. Wiley-Blackwell
Journal of Physiology, 601(10), 1761-1780. BLACKWELL PUBLISHING
Tol, A J C, Hribar, K, Kruit, J, Bongiovanni, L, Vieira-Lara, M A, Koster, M H, Kloosterhuis, N J, Havinga, R, Koehorst, M, de Bruin, A, Bakker, B M, Oosterveer, M H & van der Beek, E M 2023, ' Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model ', Journal of Physiology, vol. 601, no. 10, pp. 1761-1780 . https://doi.org/10.1113/JP284061
Journal of Physiology, 601(10), 1761-1780. BLACKWELL PUBLISHING
Tol, A J C, Hribar, K, Kruit, J, Bongiovanni, L, Vieira-Lara, M A, Koster, M H, Kloosterhuis, N J, Havinga, R, Koehorst, M, de Bruin, A, Bakker, B M, Oosterveer, M H & van der Beek, E M 2023, ' Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model ', Journal of Physiology, vol. 601, no. 10, pp. 1761-1780 . https://doi.org/10.1113/JP284061
Hyperglycaemia in pregnancy (HIP) is a pregnancy complication characterized by mild to moderate hyperglycaemia that negatively impacts short- and long-term health of mother and child. However, relationships between severity and timing of pregnancy hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1ee18648d2bd9e7fcfb867525e4768
https://dspace.library.uu.nl/handle/1874/429424
https://dspace.library.uu.nl/handle/1874/429424
