Clinical implications of incorporating genetic and non-genetic risk factors in CanRisk-based breast cancer risk prediction.

Autor: Tüchler A; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., De Pauw A; Institut Curie, Department of Genetics, Paris, France; Université PSL, Paris, France., Ernst C; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Anota A; Department of Clinical Research and Innovation, Centre Léon Bérard, Lyon, France; Human and Social Sciences Department, Centre Léon Bérard, Lyon, France; French National Platform Quality of Life and Cancer, Centre Léon Bérard, Lyon, France., Lakeman IMM; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Dick J; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., van der Stoep N; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands., van Asperen CJ; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands., Maringa M; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Herold N; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Blümcke B; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Remy R; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Westerhoff A; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Stommel-Jenner DJ; Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Frouin E; Université PSL, Paris, France; Clinical Bioinformatics Unit, Institut Curie, Paris, France., Richters L; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Golmard L; Institut Curie, Department of Genetics, Paris, France; Université PSL, Paris, France., Kütting N; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Colas C; Institut Curie, Department of Genetics, Paris, France; Université PSL, Paris, France; Institut Curie, Inserm U830, Paris, France., Wappenschmidt B; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Rhiem K; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Devilee P; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands., Stoppa-Lyonnet D; Institut Curie, Department of Genetics, Paris, France; Institut Curie, Inserm U830, Paris, France; Université Paris Cité, Paris, France., Schmutzler RK; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany., Hahnen E; Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany. Electronic address: eric.hahnen@uk-koeln.de.

Publikováno v: Breast (Edinburgh, Scotland) [Breast] 2024 Feb; Vol. 73, pp. 103615. Date of Electronic Publication: 2023 Nov 29.

Prevalence of somatic mutations in risk genes including BRCA1/2 in consecutive ovarian cancer patients (AGO-TR-1 study)

Autor: Hauke, J., Hahnen, E., Burges, A., Reuss, A., de Gregorio, Nikolaus, El-Balat, A., Richters, L., Hilpert, F., Schmidt, S., Meier, W., Gevensleben, H., Heubner, Martin, Dietrich, D., Kast, K., Braicu, E., Neunhoeffer, T., Schmutzler, R. K., Harter, P.

Poster-Abstract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=unidue___bib::9aaadf47c2bd22db77135a1cf16e7023

Ovarian Cancer-Specific BRCA -like Copy-Number Aberration Classifiers Detect Mutations Associated with Homologous Recombination Deficiency in the AGO-TR1 Trial.

Autor: Schouten PC; Department of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands. p.schouten@nki.nl., Richters L; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Vis DJ; Department of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, the Netherlands., Kommoss S; Department of Women's Health, Tübingen University Hospital, Tübingen, Germany., van Dijk E; Department of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, the Netherlands., Ernst C; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Kluin RJC; Genomics Core Facility, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands., Marmé F; Department of Gynecologic Oncology, Medical Faculty Mannheim, University of Heidelberg, University Hospital Mannheim, Mannheim, Germany., Lips EH; Department of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Schmidt S; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Scheerman E; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Prieske K; Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., van Deurzen CHM; Department of Pathology, Erasmus MC, Rotterdam, the Netherlands., Burges A; Department of Gynecology and Obstetrics, University Hospital Munich-Großhadern, Munich, Germany., Ewing-Graham PC; Department of Pathology, Erasmus MC, Rotterdam, the Netherlands., Dietrich D; Department of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany., Jager A; Department of Medical Oncology, Erasmus MC, Rotterdam, the Netherlands., de Gregorio N; Department of Gynecology and Obstetrics, University Hospital, University of Ulm, Ulm, Germany., Hauke J; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., du Bois A; Department of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Germany., Nederlof PM; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Wessels LF; Department of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, the Netherlands.; Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, the Netherlands., Hahnen E; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Harter P; Department of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Germany., Linn SC; Department of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., Schmutzler RK; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Dec 01; Vol. 27 (23), pp. 6559-6569. Date of Electronic Publication: 2021 Sep 30.

Molecular profiling reveals novel therapeutic targets and clonal evolution in ovarian clear cell carcinoma.

Autor: Chao, Angel^1,2 (AUTHOR), Huang, Chen-Yang^3,4,5 (AUTHOR), Yu, Willie^4,5 (AUTHOR), Lin, Chiao-Yun^1,2 (AUTHOR), Lin, Hao⁶ (AUTHOR), Chao, An-Shine^1,7 (AUTHOR), Lin, Cheng-Tao^1,2 (AUTHOR), Chou, Hung-Hsueh^1,2 (AUTHOR), Huang, Kuang-Gen^1,2 (AUTHOR), Huang, Huei-Jean^1,2 (AUTHOR), Chang, Ting-Chang^1,2 (AUTHOR), Rozen, Steven G.^4,5,8 (AUTHOR), Wu, Ren-Chin^2,9 (AUTHOR) qby@cgmh.org.tw, Lai, Chyong-Huey^1,2 (AUTHOR) laich46@cgmh.org.tw

Publikováno v: BMC Cancer. 11/14/2024, Vol. 24, p1-14. 14p.

Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer.

Autor: Weber-Lassalle N; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Borde J; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Weber-Lassalle K; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Horváth J; Institute for Human Genetics, University Hospital Muenster, Muenster, Germany., Niederacher D; Department of Gynaecology and Obstetrics, University Hospital Duesseldorf, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany., Arnold N; Institute of Clinical Molecular Biology, Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany., Kaulfuß S; Institute of Human Genetics, University Medical Center, Georg August University, Goettingen, Germany., Ernst C; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Paul VG; Institute for Human Genetics, University Hospital Muenster, Muenster, Germany., Honisch E; Department of Gynaecology and Obstetrics, University Hospital Duesseldorf, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany., Klaschik K; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Volk AE; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kubisch C; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rapp S; Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany., Lichey N; Institute for Human Genetics, University Hospital Muenster, Muenster, Germany., Altmüller J; Cologne Center for Genomics, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Lepkes L; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Pohl-Rescigno E; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Thiele H; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Nürnberg P; Cologne Center for Genomics, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Larsen M; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Richters L; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Rhiem K; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Wappenschmidt B; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany., Meindl A; Department of Gynaecology and Obstetrics, University of Munich, Campus Großhadern, Munich, Germany., Schmutzler RK; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany., Hahnen E; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany. eric.hahnen@uk-koeln.de., Hauke J; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 34, 50931, Cologne, Germany.

Publikováno v: Breast cancer research : BCR [Breast Cancer Res] 2019 Apr 29; Vol. 21 (1), pp. 55. Date of Electronic Publication: 2019 Apr 29.