Anti-inflammatory potential of aspergillus unguis SP51-EGY: TLR4-dependent effects & chemical diversity via Q-TOF LC-HRMS.

Autor: Nasr, Soad^1,2 (AUTHOR), Dawood, Abdelhameed S.¹ (AUTHOR), Ibrahim, Amal Mosad³ (AUTHOR), Abdel-Aziz, Mohamed S.⁴ (AUTHOR), Fayad, Walid⁵ (AUTHOR), Abdelnaser, Anwar¹ (AUTHOR) anwar.abdelnaser@aucegypt.edu, EL-Hady, Faten K. Abd³ (AUTHOR)

Publikováno v: BMC Biotechnology. 9/18/2024, Vol. 24 Issue 1, p1-21. 21p.

The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes.

Autor: Brennan MS; Neurology Research, Biogen Inc., Cambridge, MA, 02142, USA.; Boston University School of Medicine, Boston, MA 02118, USA., Matos MF; Neurology Research, Biogen Inc., Cambridge, MA, 02142, USA., Richter KE; Neurology Research, Biogen Inc., Cambridge, MA, 02142, USA., Li B; Neurology Research, Biogen Inc., Cambridge, MA, 02142, USA., Scannevin RH; Neurology Research, Biogen Inc., Cambridge, MA, 02142, USA.

Publikováno v: Scientific reports [Sci Rep] 2017 Feb 09; Vol. 7, pp. 42054. Date of Electronic Publication: 2017 Feb 09.

Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.

Autor: Liang SH; Gordon Center for Medical Imaging & Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA., Chen JM; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Normandin MD; Gordon Center for Medical Imaging & Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA., Chang JS; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Chang GC; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Taylor CK; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Trapa P; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA, 02139, USA., Plummer MS; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Para KS; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Conn EL; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Lopresti-Morrow L; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Lanyon LF; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Cook JM; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Richter KE; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Nolan CE; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Schachter JB; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Janat F; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Che Y; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Shanmugasundaram V; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Lefker BA; Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA, 02139, USA., Enerson BE; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA., Livni E; Gordon Center for Medical Imaging & Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA., Wang L; Gordon Center for Medical Imaging & Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA., Guehl NJ; Gordon Center for Medical Imaging & Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA., Patnaik D; Departments of Neurology & Psychiatry, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA., Wagner FF; Stanley Center for Psychiatric Research, Broad Institute, 415 Main Street, Cambridge, MA, o2142, USA., Perlis R; Stanley Center for Psychiatric Research, Broad Institute, 415 Main Street, Cambridge, MA, o2142, USA.; Departments of Neurology & Psychiatry, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA., Holson EB; Stanley Center for Psychiatric Research, Broad Institute, 415 Main Street, Cambridge, MA, o2142, USA., Haggarty SJ; Departments of Neurology & Psychiatry, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA., El Fakhri G; Gordon Center for Medical Imaging & Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA., Kurumbail RG; Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA. ravi.g.kurumbail@pfizer.com., Vasdev N; Gordon Center for Medical Imaging & Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA. vasdev.neil@mgh.harvard.edu.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2016 Aug 08; Vol. 55 (33), pp. 9601-5. Date of Electronic Publication: 2016 Jun 29.

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: discovery of PF-3084014.

Autor: Brodney MA; Neuroscience Medicinal Chemistry, Pfizer PharmaTherapeutics Research and Development, Eastern Point Road, Groton, CT 06340, USA. michael.a.brodney@pfizer.com, Auperin DD, Becker SL, Bronk BS, Brown TM, Coffman KJ, Finley JE, Hicks CD, Karmilowicz MJ, Lanz TA, Liston D, Liu X, Martin BA, Nelson RB, Nolan CE, Oborski CE, Parker CP, Richter KE, Pozdnyakov N, Sahagan BG, Schachter JB, Sokolowski SA, Tate B, Wood DE, Wood KM, Van Deusen JW, Zhang L

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 May 01; Vol. 21 (9), pp. 2637-40. Date of Electronic Publication: 2010 Dec 30.

Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.

Autor: Lanz TA; Neuroscience Research Unit, Pfizer, Inc., Groton, CT 06340, USA. thomas.a.lanz@pfizer.com, Wood KM, Richter KE, Nolan CE, Becker SL, Pozdnyakov N, Martin BA, Du P, Oborski CE, Wood DE, Brown TM, Finley JE, Sokolowski SA, Hicks CD, Coffman KJ, Geoghegan KF, Brodney MA, Liston D, Tate B

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2010 Jul; Vol. 334 (1), pp. 269-77. Date of Electronic Publication: 2010 Apr 02.