Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Richmond Muimo"'
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273797 (2022)
There is growing evidence to suggest that phosphohistidines are present at significant levels in mammalian cells and play a part in regulating cellular activity, in particular signaling pathways related to cancer. Because of the chemical instability
Externí odkaz:
https://doaj.org/article/573de6f031b249249d353038f7557999
Autor:
Bezaleel Mambwe, Kurt Neo, Hanif Javanmard Khameneh, Keith Weng Kit Leong, Mariasilvia Colantuoni, Maurizio Vacca, Richmond Muimo, Alessandra Mortellaro
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The inflammasome is an intracellular multi-protein complex that orchestrates the release of the pro-inflammatory cytokines IL-1β and IL-18, and a form of cell death known as pyroptosis. Tyrosine phosphorylation of the inflammasome sensors NLRP3, AIM
Externí odkaz:
https://doaj.org/article/2f366aa1786c4e13856d1956de1a5a22
Autor:
Lee A Borthwick, Mathieu Kerbiriou, Christopher J Taylor, Giorgio Cozza, Ioan Lascu, Edith H Postel, Diane Cassidy, Pascal Trouvé, Anil Mehta, Louise Robson, Richmond Muimo
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149097 (2016)
Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent protein kinase A (PKA) and ATP-regulated chloride channel. Here, we demonstrate that nucleoside diphosphate kinase B (NDPK-B, N
Externí odkaz:
https://doaj.org/article/13fb56c72b124d73b03ae1b775667e52
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28166 (2011)
BACKGROUND: TRPV6 ion channels are key mediators of regulated transepithelial absorption of Ca2+ within the small intestine. Trpv6-/- mice were reported to have lower bone density than wild-type littermates and significant disturbances in calcium hom
Externí odkaz:
https://doaj.org/article/f935f6d0325d479b9fda13c3375eed7c
Autor:
Mehul Makwana, Cleide dos Santos Souza, Barry T. Pickup, Mark J. Thompson, Santosh K. Lomada, Yuxi Feng, Thomas Wieland, Richard FW Jackson, Richmond Muimo
Publikováno v:
ChemBioChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fba6a074e156bd97a63b5a8a45c7d87
https://doi.org/10.1002/cbic.202300182
https://doi.org/10.1002/cbic.202300182
Autor:
Mehul V. Makwana, Michael P. Williamson, Richard F. W. Jackson, Sandra van Meurs, Richmond Muimo, Andrea M. Hounslow
Protein phosphorylation plays a key role in many cellular processes but there is presently no accurate information or reliable procedure to determine the relative abundance of many phosphoamino acids in cells. At pH ≤ 8, phosphohistidine is unstabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6be4d6f2ea826a711af85a087a35274
https://doi.org/10.1101/2020.12.03.409540
https://doi.org/10.1101/2020.12.03.409540
Autor:
Mehul Makwana, Cleide Dos Santos Souza, Barry T. Pickup, Mark J. Thompson, Santosh Kumar Lomada, Yushi Feng, Thomas Wieland, Richard F. W. Jackson, Richmond MUIMO
Non-hydrolysable stable analogues of τ-pHis and π-pHis have been designed using electrostatic surface potential calculations, and subsequently synthesized. The τ-pHis and π-pHis analogues (phosphopyrazole 8 and pyridyl amino amide 13, respectivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fdc6226da1290a1dd6edfc80af08c8
https://doi.org/10.26434/chemrxiv.12993371.v1
https://doi.org/10.26434/chemrxiv.12993371.v1
Autor:
Paul V. Attwood, Richmond Muimo
Publikováno v:
Laboratory Investigation. 98:283-290
Nucleoside diphosphate kinases (NDPKs) are multifunctional proteins encoded by the nme (non-metastatic cells) genes, also called NM23. NDPKs catalyze the transfer of γ-phosphate from nucleoside triphosphates to nucleoside diphosphates by a ping-pong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a82cf14416e97457a9f9af5f8a6f607
https://doi.org/10.1038/labinvest.2017.125
https://doi.org/10.1038/labinvest.2017.125
Publikováno v:
Chemical Communications. 51:7305-7308
We report the synthesis of a stable analogue of τ-phosphohistidine: 4-phosphopyrazol-2-yl alanine (pPza). Polyclonal antibodies generated against the mimic show high reactivity and selectivity for τ-phosphohistidine, with minor or no cross-reactivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e8a374a2882c9b38805196e8c5cb7e
https://doi.org/10.1039/c5cc01811k
https://doi.org/10.1039/c5cc01811k
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 98(3)
Protein phosphorylation is an important post-translational modification that is an integral part of cellular function. The O-phosphorylated amino-acid residues, such as phosphoserine (pSer), phosphothreonine (pThr) and phosphotyrosine (pTyr), have do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f31d3a27c346878f731cd3ae613dd91
https://pubmed.ncbi.nlm.nih.gov/30305721
https://pubmed.ncbi.nlm.nih.gov/30305721