Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Richelle Legaspi"'
Autor:
Sirintorn Stantripop, Sean Black, Ricardo D’Oliveira Albanus, S. L. Ho, John P. Didion, Beatrice B. Barnabas, Francis S. Collins, Brian P. Schmidt, Peter Orchard, Quino Maduro, Casandra Montemayor, Christina Sison, Karen L. Mohlke, Hannah J Perrin, K. Alaine Broadaway, Alice C. Young, Juyun Kim, Morgan Park, Laura J. Scott, Swarooparani Vadlamudi, Erin G. Schuetz, Karen Schandler, Narisu Narisu, James W. Thomas, Richelle Legaspi, Shelise Brooks, Gerard G. Bouffard, Joel Han, Federico Innocenti, Nancy Riebow, Vivek Rai, Lyudmila Dekhtyar, James C. Mullikin, Stephen C. J. Parker, Michael R. Erdos, Holly Coleman, Tingfen Yan, Catherine A. Masiello, Lori L. Bonnycastle, Jacqueline R. Idol, Amarjit S. Chaudhry, Jennifer C. McDowell, Kevin W Currin, Meghana Vemulapalli, Pamela J. Thomas, Amy S. Etheridge
Publikováno v:
Am J Hum Genet
Identifying the molecular mechanisms by which genome-wide association study (GWAS) loci influence traits remains challenging. Chromatin accessibility quantitative trait loci (caQTLs) help identify GWAS loci that may alter GWAS traits by modulating ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bebdd55fe1d80ed53db25b6e571c5a0
https://pubmed.ncbi.nlm.nih.gov/34038741
https://pubmed.ncbi.nlm.nih.gov/34038741
Autor:
Carsten G. Bönnemann, Francis J. McMahon, Quino Maduro, Alan T. Remaley, Brian P. Brooks, Sirintorn Stantripop, Jennifer C. McDowell, Kendall L. Umstead, Gerard G. Bouffard, Erin Turbitt, Catherine A. Masiello, Karen Schandler, Jeffrey Baron, Jennifer J. Johnston, Beatrice B. Barnabas, Richelle Legaspi, James W. Thomas, Holly Coleman, Eileen Pelayo, Barbara B. Biesecker, D. Nadine Dogbe, Ilias Alevizos, Joel Moss, W. Marston Linehan, Helen C. Su, Casandra Montemayor, Brian Schmidt, Alice C. Young, Morgan Park, Meghana Vemulapalli, Richard M. Siegel, Pamela J. Thomas, Chanthra Scharer, Youn Hee Jee, Deborah Nielsen, Carlos A. Zarate, Christina Sison, Leslie G. Biesecker, Alexis R Heidlebaugh, Sandra Donkervoort, Nancy Riebow, Shelise Brooks, James C. Mullikin, Teri A. Manolio, Julie C. Sapp, Xiaobin Guan, Ane Miren Sagardia, S. L. Ho, Kate Driscoll, Joel Han, Lyudmila Dekhtyar
© 2018 While consensus regarding the return of secondary genomic findings in the clinical setting has been reached, debate about such findings in the research setting remains. We developed a hybrid, research-clinical translational genomics process f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8f30234ebb7d1b8ff21c42057bf2c8
https://europepmc.org/articles/PMC6128311/
https://europepmc.org/articles/PMC6128311/
Autor:
John R. Mascola, Quino Maduro, Christina Sison, Jenny McDowell, Chaim A. Schramm, Lawrence Shapiro, Brian P. Schmidt, Betty Benjamin, Karen Schandler, Cathy Masiello, Richelle Legaspi, Pam Thomas, James Thomas, Zizhang Sheng, Nisc Comparative Sequencing Program, Raymond Arthur Smith, Jessica Rosarda, Xiaobin Guan, Shelise Brooks, James C. Mullikin, Mila Dekhtyar, Nancy Riebow, Joel Han, Gerry Bouffard, Holly Coleman, Casandra Montemayor, Meg Vemulapalli, Mal Stantripop, Peter D. Kwong, Rui Kong, Alice Young, Morgan Park, Shi ling Ho
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology, Vol 8 (2017)
Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56819f330845f00b676af91b1c7b420a
https://pubmed.ncbi.nlm.nih.gov/28539926
https://pubmed.ncbi.nlm.nih.gov/28539926
Autor:
Sean Lovett, Stephen C. J. Parker, Holly Coleman, Narisu Narisu, D. Leland Taylor, Morgan Park, Len A. Pennacchio, Taccara Johnson, Jenny McDowell, Baishali Maskeri, Meg Vemulapalli, Axel Visel, April Hargrove, Jennifer A. Akiyama, James Thomas, Michael R. Erdos, Cathy Masiello, Michael D. Gregory, Brian L. Schmidt, Peter S. Chines, Michael L. Stitzel, Quino Maduro, Betty Benjamin, Shi-ling Ho, Robert W. Blakesley, Xiaobin Guan, Francis S. Collins, Karen Schandler, Mal Stantripop, Casandra Montemayor, Richelle Legaspi, Jesse Becker, Kelly Lammerts van Bueren, Alice Young, Nancy Riebow, James C. Mullikin, Christina Sison, Jyoti Gupta, Nisc Comparative Sequencing Program, Mila Dekhtyar, Joel Han, Jose M. Orozco, Brian L. Black, Pam Thomas, Shelise Brooks, Gerry Bouffard
Publikováno v:
Proceedings of the National Academy of Sciences. 110:17921-17926
Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcripto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2966a51d8f04562c79bd26ef7f5490
https://doi.org/10.1073/pnas.1317023110
https://doi.org/10.1073/pnas.1317023110
Autor:
Steven A. Rosenberg, Quino Maduro, Sean Lovett, Hannah Carter, Laura Elnitski, Sean Davis, Betty Benjamin, Nicholas K. Hayward, J. Lin, Michael D. Gregory, Chava Kimchi-Sarfaty, James Thomas, Michael A. Davies, Michael L. Stitzel, Rachel Karchin, Alice Young, Pam Thomas, Xiaobin Guan, Casandra Montemayor, Jesse Becker, Jamie K. Teer, Nancy Riebow, Shelise Brooks, Elliott H. Margulies, Gerry Bouffard, Holly Coleman, Jyoti Gupta, Brian L. Schmidt, Morgan Park, James C. Mullikin, Karen Schandler, Francis S. Collins, Cathy Masiello, Xiaomu Wei, Baishali Maskeri, Sujata Jha, William A. Robinson, Richelle Legaspi, Yardena Samuels, Shi-ling Ho, Steven E. Robinson, Christina Sison, Ken Dutton-Regester, Meg Vemulapalli, Todd D. Prickett, Jenny McDowell, Valer Gotea, Taccara Johnson, Nobuko H. Katagiri, Robert W. Blakesley, Umesh Bhanot, Guo Chen, Vijaya L. Simhadri, Stephen C. J. Parker, Jared J. Gartner, Mal Stantripop, Mila Dekhtyar, Jeffrey E. Gershenwald, Joel Han, Mario A. Morken, Giovanni Parmigiani, April Hargrove, Anton A. Komar
Publikováno v:
Proceedings of the National Academy of Sciences. 110:13481-13486
Synonymous mutations, which do not alter the protein sequence, have been shown to affect protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12(10):683–691]. However, synonymous mutations are rarely investigated in the cancer genomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73128767d86eb42c6e030e181b9b629f
https://doi.org/10.1073/pnas.1304227110
https://doi.org/10.1073/pnas.1304227110
Autor:
John R. Mascola, Yongping Yang, Melissa Simek, S. Munir Alam, Christina Sison, Sean Lovett, April Hargrove, Julie Blinn, Robert W. Blakesley, Cathy Masiello, Nancy Riebow, Lawrence Shapiro, James C. Mullikin, Gabriel Lu, Jeff Skinner, Dennis R. Burton, Krisha McKee, Pam Thomas, Barton F. Haynes, Joshua Eudailey, Shi-ling Ho, Betty Benjamin, Nisc Comparative Sequencing Program, Holly Coleman, Jiang Zhu, Quino Maduro, Zhenhai Zhang, Mila Dekhtyar, Gilad Ofek, Karen Schandler, Joel Han, Richelle Legaspi, Jenny McDowell, Taccara Johnson, Mal Stantripop, Jesse Becker, Krissey E. Lloyd, James Thomas, Shelise Brooks, Gerry Bouffard, Alice Young, Baoshan Zhang, Meg Vemulapalli, Brian L. Schmidt, Marie Pancera, Peter D. Kwong, Mark K. Louder, Baishali Maskeri, Morgan Park, Robert Parks, Jyoti Gupta, Michael D. Gregory, Wayne C. Koff, Xiaobin Guan, Casandra Montemayor
Publikováno v:
Proceedings of the National Academy of Sciences. 110:6470-6475
Next-generation sequencing of antibody transcripts from HIV-1–infected individuals with broadly neutralizing antibodies could provide an efficient means for identifying somatic variants and characterizing their lineages. Here, we used 454 pyroseque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b087750599718ed65d8607625ce81ff2
https://doi.org/10.1073/pnas.1219320110
https://doi.org/10.1073/pnas.1219320110
Autor:
Chung-Yi Wu, Michael Gregory, Brian P. Schmidt, Peter D. Kwong, Reda Rawi, Yongping Yang, Cathy Masiello, Chang-Chun D Lee, James C. Mullikin, Shi-ling Ho, Anqi Zheng, John R. Mascola, Karen Schandler, Richelle Legaspi, Holly Coleman, Chen-Hsiang Shen, Mila Dekhtyar, Catherine Stevenson, Vidya S. Shivatare, Joel Han, Rui Kong, Xiaobin Guan, Casandra Montemayor, Gwo-Yu Chuang, Dennis R. Burton, Krisha McKee, Jenny McDowell, Eric Waltari, Pam Thomas, Justin Taft, Chi-Huey Wong, Mal Stantripop, Sijy O'Dell, Xueling Wu, Morgan Park, Shelise Brooks, Meg Vemulapalli, Gerry Bouffard, Lawrence Shapiro, Mark K. Louder, Robert W. Blakesley, Baishali Maskeri, Victoria R. Polonis, Ivelin S. Georgiev, Sachin S. Shivatare, Yaroslav Tsybovsky, Baoshan Zhang, April Hargrove, Syna Gift, Tongqing Zhou, Betty Benjamin, Syed Shahzad-ul-Hussan, Alice Young, James W. Thomas, Carole A. Bewley, Jyoti Gupta, Guillaume Stewart-Jones, Quino Maduro, Nancy Riebow, Christina Sison, Robert T. Bailer, Ulrich Baxa
Publikováno v:
Immunity. 48:500-513.e6
Summary Virtually the entire surface of the HIV-1-envelope trimer is recognized by neutralizing antibodies, except for a highly glycosylated region at the center of the "silent face" on the gp120 subunit. From an HIV-1-infected donor, #74, we identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34ddd9d2ad313941c9715e018cf74cf
https://doi.org/10.1016/j.immuni.2018.02.013
https://doi.org/10.1016/j.immuni.2018.02.013
Autor:
Adrian M. Zelazny, Julie A. Segre, Quino Maduro, Jyoti Gupta, Lilia A. Mijares, Holly Coleman, Morgan Park, Pam Thomas, Patrick R. Murray, Marie Gestole, Lauren H. Smith, Clemente I. Montero, Robert W. Blakesley, Michael D. Gregory, Christina Sison, Jim C. Mullikin, Sean Lovett, April Hargrove, Shelise Brooks, Grace Chu, Evan S. Snitkin, Xiaobin Guan, Brian L. Schmidt, Mila Dekhtyar, Casandra Montemayor, Gerry Bouffard, Mal Stantripop, Frida Stock, Joel Han, Nancy Riebow, Jerlil Myrick, Colleen Ramsahoye, Alice Young, Betty Benjamin, Baishali Maskeri, Karen Schandler, Richelle Legaspi, Betsy Novotny, Cathy Masiello, Shi-ling Ho, Taccara Johnson, Jenny McDowell
Acinetobacter baumannii is an emerging human pathogen and a significant cause of nosocomial infections among hospital patients worldwide. The enormous increase in multidrug resistance among hospital isolates and the recent emergence of pan-drug–res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87900db12ab6f73cc2976f0a460b7451
https://europepmc.org/articles/PMC3158218/
https://europepmc.org/articles/PMC3158218/
Autor:
Stephen M. Beckstrom-Sternberg, Donna Karolchik, Baoli Zhu, M. C. Huang, Tyrone J. Summers, J. T. Tran, Jeffrey W. Touchman, Jacquelyn R. Idol, L. S. Wiggins, James W. Thomas, Charles P. Brinkley, N. Akhter, Scott Schwartz, M. S. Schwartz, Laura Elnitski, Nancy F. Hansen, Eric D. Green, David J. Cutler, Quino Maduro, Aravinda Chakravarti, Mathieu Blanchette, K. Ayele, Robert W. Blakesley, J. C. McCloskey, Sirintorn Stantripop, Shih-Queen Lee-Lin, Keith Wetherby, Elliott H. Margulies, Alice C. Young, Nicole Dietrich, M. A. Walker, Stephen D. Mastrian, P. L. Laric, Jenny McDowell, Richelle Legaspi, B. Zhao, S. L. Ho, Webb Miller, R. Bevan, Pamela J. Thomas, Philip Green, Kazutoyo Osoegawa, Emmanuelle Tiongson, Betty Benjamin, S. Granite, P. Haghighi, L. H. Zhang, Cathy Masiello, Arian F.A. Smit, Baishali Maskeri, Jennifer Vogt, T. C. Bruen, W. J. Kent, David Haussler, Eric Karlins, P. J. De Jong, Matthew E. Portnoy, R. J. Weber, C. L. Shu, C. Tsurgeon, Xin-Yuan Guan, R. Pearson, K. Cariaga, Shelise Brooks, Gerry Bouffard, Arjun B. Prasad, Adam Siepel, Charles E. Lawrence, Jyoti Gupta, M. J. Lim, Valerie Maduro
Publikováno v:
Nature. 424(6950)
The systematic comparison of genomic sequences from different organisms represents a central focus of contemporary genome analysis. Comparative analyses of vertebrate sequences can identify coding1,2,3,4,5,6 and conserved non-coding4,6,7 regions, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bf163bc04c79abc0a10b0563ab4c9e
https://pubmed.ncbi.nlm.nih.gov/12917688
https://pubmed.ncbi.nlm.nih.gov/12917688
Autor:
John R. Mascola, Robert T. Bailer, Baoshan Zhang, Betty Benjamin, Peter D. Kwong, Cinque Soto, Michael D. Gregory, Chaim A. Schramm, M. Gordon Joyce, Xiaobin Guan, Lawrence Shapiro, Casandra Montemayor, Cathy Masiello, Brian L. Schmidt, Tongqing Zhou, Robert W. Blakesley, Rebecca M. Lynch, Xueling Wu, Morgan Park, Christina Sison, Shi-ling Ho, Mark K. Louder, Baishali Maskeri, Shelise Brooks, Nancy S. Longo, Mark Connors, Nancy Riebow, Quino Maduro, Sijy O'Dell, Alice Young, Sanjay Srivatsan, Young Do Kwon, Mila Dekhtyar, Kevin O. Saunders, James C. Mullikin, Gerry Bouffard, Joel Han, Jenny McDowell, Yongping Yang, Jyoti Gupta, Krisha McKee, Pam Thomas, Karen Schandler, Richelle Legaspi, Ivelin S. Georgiev, Zhenhai Zhang, Holly Coleman, Meg Vemulapalli, James Thomas, April Hargrove, Gwo-Yu Chuang, Mal Stantripop, Zizhang Sheng
Publikováno v:
Cell. (3):470-485
SummaryHIV-1-neutralizing antibodies develop in most HIV-1-infected individuals, although highly effective antibodies are generally observed only after years of chronic infection. Here, we characterize the rate of maturation and extent of diversity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6be0e5162d5e55f2a82bbce110bb85