Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Richele K Rasmussen"'
Autor:
Richele K. Rasmussen, Gerald H. Thomsen, Shirin Bonni, Jeffrey L. Wrana, Peter A. Kavsak, Carrie G. Causing, Haitao Zhu
Publikováno v:
Molecular Cell. 6(6):1365-1375
Ubiquitin-mediated proteolysis regulates the activity of diverse receptor systems. Here, we identify Smurf2, a C2-WW-HECT domain ubiquitin ligase and show that Smurf2 associates constitutively with Smad7. Smurf2 is nuclear, but binding to Smad7 induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dc309fb9eaf31c9c9d7d31429c3c68
Publikováno v:
Electrophoresis. 19:946-955
Two-dimensional polyacrylamide gel electrophoresis (2-DE) in combination with mass spectrometry is an extremely powerful tool for characterizing complex mixtures of proteins. In many cases, the success of this approach relies upon the ability to reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625964966b39125f83b2fdf7c89d3c63
https://doi.org/10.1002/elps.1150190610
https://doi.org/10.1002/elps.1150190610
Autor:
Gavin E. Reid, James S. Eddes, Richard J. Simpson, Richele K. Rasmussen, Robert L. Moritz, Donna S. Dorow, Hong Ji
Publikováno v:
Electrophoresis. 18:588-598
MLK2, a member of the mixed lineage kinase (MLK) family of protein kinases, first reported by Dorow et al. (Eur. J. Biochem. 1993, 213, 701-710), comprises several distinct structural domains including an src homology-3 (SH3) domain, a kinase catalyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afaf3472b18ee863821a50a1d815a38b
https://doi.org/10.1002/elps.1150180342
https://doi.org/10.1002/elps.1150180342
Autor:
Ronald Knegtel, Ian Ager, Luca Settimo, Stephen Clinton Young, Dean Boyall, Richele K Rasmussen, Claire M. Bolton, Peter Chiu, Adam P. Curnock, Christopher John Davis, Adam Tanner, Juan-Miguel Jimenez, Damien Fraysse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(14)
The identification of a novel series of PKCθ inhibitors and subsequent optimization using docking based on a crystal structure of PKCθ is described. SAR was rapidly generated around an amino pyridine-ketone hit; (6-aminopyridin-2-yl)(2-aminopyridin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcb8517f1186f9dfe4bbe54db055a35
https://pubmed.ncbi.nlm.nih.gov/22738630
https://pubmed.ncbi.nlm.nih.gov/22738630
Autor:
Abiodun A. Ogunjimi, Bruce T. Seet, Richele K. Rasmussen, Gianni M. Di Guglielmo, Douglas J. Briant, Christine Le Roy, Peter A. Kavsak, Jeffrey L. Wrana, Frank Sicheri, Nadia Pece-Barbara
Publikováno v:
Molecular cell. 19(3)
The conjugation of ubiquitin to proteins involves a cascade of activating (E1), conjugating (E2), and ubiquitin-ligating (E3) type enzymes that commonly signal protein destruction. In TGFbeta signaling the inhibitory protein Smad7 recruits Smurf2, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936f1044a4c07243417c89f4bec970cb
https://pubmed.ncbi.nlm.nih.gov/16061177
https://pubmed.ncbi.nlm.nih.gov/16061177
Autor:
Golec Julian M C, Richele K Rasmussen, Cecile Demur, Michael Su, Tomoko Nakayama, Abi O Ajose-Adeogun, Karen Miller, David Bebbington, Elizabeth A Harrington, Thierry Hercend, Anita Diu-Hercend, Jeff Moore, Joanne A Graham
Publikováno v:
Nature medicine. 10(3)
The Aurora kinases are essential for the regulation of chromosome segregation and cytokinesis during mitosis. Aberrant expression and activity of these kinases occur in a wide range of human tumors, and lead to aneuploidy and tumorigenesis. Here we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5d40f776c1a0fb8edd05d7b7dff7bc
https://pubmed.ncbi.nlm.nih.gov/14991042
https://pubmed.ncbi.nlm.nih.gov/14991042
Autor:
Jenny Rusak, Donna S. Dorow, Phillip J. Robinson, Richard J. Simpson, Richele K. Rasmussen, Gareth Price
Publikováno v:
The Biochemical journal. 335
Mixed-lineage kinase 2 (MLK2) is a cytoplasmic protein kinase expressed at high levels in mammalian brain. The MLK2 structure is composed of a Src homology 3 (SH3) domain, two leucine zippers, a basic motif, a Cdc42/Rac interactive binding motif and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e462545bf93e561180fa7a840b0b08a
https://pubmed.ncbi.nlm.nih.gov/9742220
https://pubmed.ncbi.nlm.nih.gov/9742220
Autor:
Gavin E. Reid, Robert L. Moritz, James S. Eddes, Richard J. Simpson, Hong Ji, Richele K. Rasmussen, Donna S. Dorow
Publikováno v:
Electrophoresis. 19(5)
The mixed lineage kinase 2 (MLK2) protein contains several structurally distinct domains including an src homology (SH) 3 domain, a kinase catalytic domain, two leucine zippers, a basic motif and a cdc42/rac interactive binding motif. These domains h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9c92c59536c288b47f9aade716f138
https://pubmed.ncbi.nlm.nih.gov/9629920
https://pubmed.ncbi.nlm.nih.gov/9629920
Autor:
Richele K. Rasmussen, James S. Eddes, Hong Ji, Lisa M. Zugaro, Gavin E. Reid, Richard J. Simpson, Donna S. Dorow
Publikováno v:
Electrophoresis. 19(5)
Previously, we reported a two-dimensional gel map and database with molecular weight/isoelectric point (Mr/pI) loci for 22 proteins expressed in the breast carcinoma cell line, MDA-MB231 (Rasmussen et al., Electrophoresis 1997, 18, 588-598). Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ffca34ee8fb6214a009da3b084dc4a
https://pubmed.ncbi.nlm.nih.gov/9629921
https://pubmed.ncbi.nlm.nih.gov/9629921
Autor:
Richele K. Rasmussen, Daixin Tong, Richard J. Simpson, Donna S. Dorow, Robert L. Moritz, Gavin E. Reid, James S. Eddes
Publikováno v:
Journal of protein chemistry. 16(5)
Capillary column (or = 320-micron ID) liquid chromatography is an essential tool for the separation and concentration of low-picomole amounts of proteins and peptides for mass-spectrometric based structural analysis. We describe a detailed procedure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3febc3cd1c08ce5c70dca5a688c02c9b
https://pubmed.ncbi.nlm.nih.gov/9246624
https://pubmed.ncbi.nlm.nih.gov/9246624