Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359

Autor: Hermes, Cornelia, Richarz, René, Wirtz, Daniel A., Patt, Julian, Hanke, Wiebke, Kehraus, Stefan, Voß, Jan Hendrik, Küppers, Jim, Ohbayashi, Tsubasa, Namasivayam, Vigneshwaran, Alenfelder, Judith, Inoue, Asuka, Mergaert, Peter, Gütschow, Michael, Müller, Christa E., Kostenis, Evi, König, Gabriele M., Crüsemann, Max

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, 2021, 12 (1), pp.144. ⟨10.1038/s41467-020-20418-3⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.144. ⟨10.1038/s41467-020-20418-3⟩

The potent and selective Gq protein inhibitor depsipeptide FR900359 (FR), originally discovered as the product of an uncultivable plant endosymbiont, is synthesized by a complex biosynthetic system comprising two nonribosomal peptide synthetase (NRPS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c7e750be03e5389994cc81c63d86217b
https://doaj.org/article/2463819dc4b944af9d1f08c6cace66cc

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Carrier Protein‐Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC**.

Autor: Aldemir, Hülya, Shu, Shuangjie, Schaefers, Francoise, Hong, Hanna, Richarz, René, Harteis, Sabrina, Einsiedler, Manuel, Milzarek, Tobias M., Schneider, Sabine, Gulder, Tobias A. M.

Publikováno v: Chemistry - A European Journal; 1/10/2022, Vol. 28 Issue 2, p1-6, 6p

Das biokatalytische Repertoire natürlicher Biarylbildung.

Autor: Aldemir, Hülya¹, Richarz, René¹, Gulder, Tobias A. M.¹ tobias.gulder@ch.tum.de

Publikováno v: Angewandte Chemie. Aug2014, Vol. 126 Issue 32, p8426-8433. 8p.

Heterologe Expression, Biosynthese und ökologische Funktion des selektiven Gq‐Signaltransduktionsinhibitors FR900359.

Autor: Crüsemann, Max, Reher, Raphael, Schamari, Isabella, Brachmann, Alexander O., Ohbayashi, Tsubasa, Kuschak, Markus, Malfacini, Davide, Seidinger, Alexander, Pinto‐Carbó, Marta, Richarz, René, Reuter, Tatjana, Kehraus, Stefan, Hallab, Asis, Attwood, Misty, Schiöth, Helgi B., Mergaert, Peter, Kikuchi, Yoshitomo, Schäberle, Till F., Kostenis, Evi, Wenzel, Daniela

Publikováno v: Angewandte Chemie; 1/15/2018, Vol. 130 Issue 3, p844-849, 6p