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EP08.02-031 NRF2 Pathway Signature Predicts KEAP1/NFE2L2 Mutations and Reveals Alternative Pathway-Activating Mutations in NSCLC

Autor: Arolt, C., Dugan, M., Wild, R., Richartz, V., Holz, B., Scheel, A.H., Brägelmann, J., Merkelbach-Bruse, S., Wolf, J., Büttner, R., Lafleur, F., Scheffler, M., Catanzariti, L., Hillmer, A.

Publikováno v: In Journal of Thoracic Oncology September 2022 17(9) Supplement:S411-S412

Integrative genomic analyses of European intrahepatic cholangiocarcinoma: Novel ROS1 fusion gene and PBX1 as prognostic marker.

Autor: Plum PS; Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Hess T; Center for Human Genetics, University Hospital of Marburg, Marburg, Germany., Bertrand D; Computational and Systems Biology, Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore., Morgenstern I; General, Visceral and Transplant Surgery, Johannes Gutenberg University, Mainz, Germany., Velazquez Camacho O; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Jonas C; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Alidousty C; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Wagner B; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Roessler S; Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Liver Cancer Center Heidelberg (LCCH), Heidelberg, Germany., Albrecht T; Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Liver Cancer Center Heidelberg (LCCH), Heidelberg, Germany., Becker J; Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany., Richartz V; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Holz B; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Hoppe S; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Poh HM; Cancer Therapeutics and Stratified Oncology, Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore., Chia BKH; Computational and Systems Biology, Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore., Chan CX; Cancer Therapeutics and Stratified Oncology, Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore., Pathiraja T; Cancer Therapeutics and Stratified Oncology, Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore., Teo AS; Cancer Therapeutics and Stratified Oncology, Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore., Marquardt JU; I Department of Medicine, Johannes Gutenberg University, Mainz, Germany.; Department of Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany., Khng A; Cancer Therapeutics and Stratified Oncology, Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore., Heise M; General, Visceral and Transplant Surgery, Johannes Gutenberg University, Mainz, Germany.; Department for General, Visceral and Transplant Surgery, University Hospital Frankfurt, Goethe-University Frankfurt/Main, Frankfurt, Germany., Fei Y; Cancer Therapeutics and Stratified Oncology, Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore., Thieme R; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Klein S; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Hong JH; Duke-NUS Medical School, Cancer and Stem Cell Biology, Singapore, Singapore.; Division of Medical Science, Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore., Dima SO; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania., Popescu I; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania., Hoppe-Lotichius M; General, Visceral and Transplant Surgery, Johannes Gutenberg University, Mainz, Germany., Buettner R; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Lautem A; General, Visceral and Transplant Surgery, Johannes Gutenberg University, Mainz, Germany., Otto G; Emeritus of the Division of Transplantation Surgery, University Medical Center, Mainz, Germany., Quaas A; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Nagarajan N; Computational and Systems Biology, Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore., Rozen S; Duke-NUS Medical School, Cancer and Stem Cell Biology, Singapore, Singapore., Teh BT; Duke-NUS Medical School, Cancer and Stem Cell Biology, Singapore, Singapore., Goeppert B; RKH Klinikum Ludwigsburg, Institute of Pathology and Neuropathology, Ludwigsburg, Germany.; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Drebber U; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Lang H; General, Visceral and Transplant Surgery, Johannes Gutenberg University, Mainz, Germany., Tan P; Duke-NUS Medical School, Cancer and Stem Cell Biology, Singapore, Singapore.; Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore., Gockel I; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Schumacher J; Center for Human Genetics, University Hospital of Marburg, Marburg, Germany., Hillmer AM; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cancer Therapeutics and Stratified Oncology, Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2024 Jun; Vol. 14 (6), pp. e1723.