Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Richard. O. Williams"'
Autor:
Natalya M. Kogan, Yarden Lavi, Louise M. Topping, Richard. O. Williams, Fiona E. McCann, Zhanna Yekhtin, Marc Feldmann, Ruth Gallily, Raphael Mechoulam
Publikováno v:
Molecules, Vol 26, Iss 18, p 5601 (2021)
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to p
Externí odkaz:
https://doaj.org/article/a6ffb15a4ba14101a91c716db021ac58
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9040 (2024)
It has been unequivocally established that kynurenic acid has a number of actions in a variety of cells and tissues, raising, in principle, the possibility of targeting its generation, metabolism or sites of action to manipulate those effects to a be
Externí odkaz:
https://doaj.org/article/878f796dd8c749be807b342ef317765f
Publikováno v:
Molecules, Vol 29, Iss 6, p 1398 (2024)
Short-chain fatty acids (SCFA) and lactate in ruminal fluid are products resulting from the microbial fermentation of substrates and can be used to reflect the composition and activity of the ruminal microbiome. Determination of SCFA and D-/L-lactate
Externí odkaz:
https://doaj.org/article/1371f5c0db5d44afb3603d1a4ff433c1
Autor:
Trevor W. Stone, Felix I. L. Clanchy, Yi-Shu Huang, Nien-Yi Chiang, L. Gail Darlington, Richard O. Williams
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Two of the molecular families closely associated with mediating communication between the brain and immune system are cytokines and the kynurenine metabolites of tryptophan. Both groups regulate neuron and glial activity in the central nervous system
Externí odkaz:
https://doaj.org/article/869365119ff04675ba191fd11afa3d14
Autor:
Joy Ogbechi, Yi-Shu Huang, Felix I. L. Clanchy, Eirini Pantazi, Louise M. Topping, L. Gail Darlington, Richard O. Williams, Trevor W. Stone
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Many invasive micro-organisms produce ‘quorum sensor’ molecules which regulate colony expansion and may modulate host immune responses. We have examined the ability of Pseudomonas Quorum Sensor (PQS) to influence cytokine expression under conditi
Externí odkaz:
https://doaj.org/article/0a21a9ffbdb34293be6dd44fbdbdf370
Autor:
Trevor W. Stone, Richard O. Williams
Publikováno v:
Cancers, Vol 15, Iss 11, p 2895 (2023)
The mechanisms underlying a relationship between inflammation and cancer are unclear, but much emphasis has been placed on the role of tryptophan metabolism to kynurenine and downstream metabolites, as these make a substantial contribution to the reg
Externí odkaz:
https://doaj.org/article/6f3c8386ac924c5d9aeebfa1b4c029e2
Autor:
Louise M. Topping, Laura Romero-Castillo, Vilma Urbonaviciute, Hans Bolinsson, Felix I. Clanchy, Rikard Holmdahl, B. Thomas Bäckström, Richard O. Williams
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Autoimmune murine disease models are vital tools for identifying novel targets and finding better treatments for human diseases. Complete Freund’s adjuvant is commonly used to induce disease in autoimmune models, and the quality of the adjuvant/aut
Externí odkaz:
https://doaj.org/article/b164c77abfec4f66a5c07ab3578ba63a
Autor:
S. Richard O. Williams, Joe L. Jacobs, Subhash Chandra, Martin Soust, Victoria M. Russo, Meaghan L. Douglas, Pablo S. Alvarez Hess
Publikováno v:
Animals, Vol 13, Iss 6, p 1018 (2023)
Using direct-fed microbials to mitigate enteric methane emissions could be sustainable and acceptable to both consumers and producers. Forty lactating, multiparous, Holstein-Friesian cows were randomly allocated one of two treatments: (1) a base of a
Externí odkaz:
https://doaj.org/article/1ae013f803834b36843422e232032223
Autor:
S. Richard O. Williams, Peter J. Moate, Josie B. Garner, Murray C. Hannah, Khageswor Giri, William J. Wales, Leah C. Marett
Publikováno v:
Animals, Vol 13, Iss 5, p 867 (2023)
The frequency, duration, and intensity of heat waves in Australia are increasing. To reduce the impact of heat waves on milk production, novel management strategies are required. Altering the forage type and amount offered affect the heat load on dai
Externí odkaz:
https://doaj.org/article/c41516d77243491a97a1e975d0c70c2f
Autor:
Josie B. Garner, S. Richard O. Williams, Peter J. Moate, Joe L. Jacobs, Murray C. Hannah, Greg L. Morris, William J. Wales, Leah C. Marett
Publikováno v:
Animals, Vol 12, Iss 16, p 2031 (2022)
Cereal grains that differ in the rate and extent of ruminal fermentation differ in heat increment and may be used to improve thermoregulation during heat stress. This experiment investigated the responses of dairy cows in late lactation to a heat cha
Externí odkaz:
https://doaj.org/article/510f78566f7e455fbd923e450f3f0994