Výsledky vyhledávání - "Richard de Goeij de Haas"

Akademický článek

IGF1R signaling induces epithelial-mesenchymal plasticity via ITGAV in cutaneous carcinoma

Autor: Marta Lopez-Cerda, Laura Lorenzo-Sanz, Victoria da Silva-Diz, Sandra Llop, Rosa M. Penin, Josep Oriol Bermejo, Richard de Goeij-de Haas, Sander R. Piersma, Thang V. Pham, Connie R. Jimenez, Juan Martin-Liberal, Purificación Muñoz

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-21 (2024)

Abstract Background Early cutaneous squamous cell carcinomas (cSCCs) generally show epithelial differentiation features and good prognosis, whereas advanced cSCCs present mesenchymal traits associated with tumor relapse, metastasis, and poor survival

Externí odkaz: https://doaj.org/article/2d2e3cd7ff3f4fedbed353deaa311a0c

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Akademický článek

Western diet triggers cardiac dysfunction in heterozygous Mybpc3-targeted knock-in mice: A two-hit model of hypertrophic cardiomyopathy

Autor: Edgar E. Nollet, Sila Algül, Max Goebel, Saskia Schlossarek, Nicole N. van der Wel, Judith J.M. Jans, Mark A. van de Wiel, Jaco C. Knol, Thang V. Pham, Sander R. Piersma, Richard de Goeij-de Haas, Jill Hermans, Jan Bert van Klinken, Michel van Weeghel, Riekelt H. Houtkooper, Lucie Carrier, Connie R. Jimenez, Diederik W.D. Kuster, Jolanda van der Velden

Publikováno v: Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100050- (2023)

Background and aim: Phenotypic expression of hypertrophic cardiomyopathy (HCM) and disease course are associated with unfavorable metabolic health. We investigated if Western diet (WD) feeding is sufficient to trigger cardiac hypertrophy and dysfunct

Externí odkaz: https://doaj.org/article/a35423357cb242d7a31ba3d7bed60292

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Supplementary Data from Tumor Drug Concentration and Phosphoproteomic Profiles After Two Weeks of Treatment With Sunitinib in Patients with Newly Diagnosed Glioblastoma

Autor: Henk M.W. Verheul, Connie R. Jiménez, William P. Vandertop, Thang V. Pham, Sander R. Piersma, Henk Dekker, Godefridus J. Peters, Jaco C. Knol, Alex A. Henneman, Richard de Goeij-de Haas, Richard J. Honeywell, Philip C. De Witt Hamer, Koos E. Hovinga, Cyrillo G. Brahm, Mariette Labots, Myra E. van Linde

Supplementary Data from Tumor Drug Concentration and Phosphoproteomic Profiles After Two Weeks of Treatment With Sunitinib in Patients with Newly Diagnosed Glioblastoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0592bc394e56094954a93738d20c1215
https://doi.org/10.1158/1078-0432.22482687.v1

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Data from Tumor Drug Concentration and Phosphoproteomic Profiles After Two Weeks of Treatment With Sunitinib in Patients with Newly Diagnosed Glioblastoma

Purpose:Tyrosine kinase inhibitors (TKI) have poor efficacy in patients with glioblastoma (GBM). Here, we studied whether this is predominantly due to restricted blood–brain barrier penetration or more to biological characteristics of GBM.Patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbdf25f191602c2463adb0ddbebdbb1
https://doi.org/10.1158/1078-0432.c.6530979

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Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies

Autor: Nick D. Bergkamp, Martine J. Smit, Truc Giap, Connie R. Jimenez, K. Christopher Garcia, Hidde L. Ploegh, Timo W.M. De Groof, Maarten P. Bebelman, Richard de Goeij de Haas, Raimond Heukers, Sander R. Piersma, Marco Siderius

Publikováno v: Nature Communications
Nature Communications, 12(1):4357. Nature Publishing Group
De Groof, T W M, Bergkamp, N D, Heukers, R, Giap, T, Bebelman, M P, Goeij-de Haas, R, Piersma, S R, Jimenez, C R, Garcia, K C, Ploegh, H L, Siderius, M & Smit, M J 2021, ' Selective targeting of ligand-dependent and-independent signaling by GPCR conformation-specific anti-US28 intrabodies ', Nature Communications, vol. 12, no. 1, pp. 4357 . https://doi.org/10.1038/s41467-021-24574-y
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, 12(1). Nature Publishing Group UK
De Groof, T W M, Bergkamp, N D, Heukers, R, Giap, T, Bebelman, M P, Goeij-de Haas, R, Piersma, S R, Jimenez, C R, Garcia, K C, Ploegh, H L, Siderius, M & Smit, M J 2021, ' Selective targeting of ligand-dependent and-independent signaling by GPCR conformation-specific anti-US28 intrabodies ', Nature Communications, vol. 12, no. 1, 4357 . https://doi.org/10.1038/s41467-021-24574-y

While various GPCRs, including US28, display constitutive, ligand-independent activity, it remains to be established whether ligand-dependent and -independent active conformations differ and can be selectively modulated. Previously, the agonist-bound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34630bbac1bf5a3229244884d5e7a47
http://europepmc.org/articles/PMC8285524

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Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome

Autor: Richard J. Honeywell, Connie R. Jimenez, Godefridus J. Peters, Sander R. Piersma, Martijn R. Meijerink, Robin Beekhof, Richard de Goeij de Haas, Maarten Neerincx, Jaco C. Knol, Donald L. van der Peet, Nicole C.T. van Grieken, Thang V. Pham, Johannes C. van der Mijn, Henk M.W. Verheul, Henk L. Dekker, Mariette Labots

Publikováno v: Cancers, 12(2):330. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 12
Cancers
Volume 12
Issue 2
Cancers, 12, 2
Labots, M, Pham, T V, Honeywell, R J, Knol, J C, Beekhof, R, de Goeij-de Haas, R, Dekker, H, Neerincx, M, Piersma, S R, van der Mijn, J C, van der Peet, D L, Meijerink, M R, Peters, G J, van Grieken, N C T, Jiménez, C R & Verheul, H M W 2020, ' Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome ', Cancers, vol. 12, no. 2, 330 . https://doi.org/10.3390/cancers12020330
Cancers, Vol 12, Iss 2, p 330 (2020)

Identification of predictive biomarkers for targeted therapies requires information on drug exposure at the target site as well as its effect on the signaling context of a tumor. To obtain more insight in the clinical mechanism of action of protein k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9ab5f80e090bb9908796d5a68427f5
https://research.vumc.nl/en/publications/0819c55f-746c-40ee-882b-d23b37439956

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Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Targetable Kinase Activities and Novel Treatment Combination Strategies

Autor: Jelle Dylus, Jules P.P. Meijerink, Sander R. Piersma, Thang V. Pham, Rico Hagelaar, Guido J.R. Zaman, Richard de Goeij-de Haas, Connie R. Jimenez, Valentina Cordo

Publikováno v: Blood. 136:14-15

Introduction Intensive multi-agent treatment has boosted survival up to 80% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients. Nevertheless, relapsed patients have a poor prognosis due to acquired therapy resistance while most survivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0c4ddf4b310c54ad750357947ed97a8
https://doi.org/10.1182/blood-2020-139259

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Prediction of response to sunitinib in patients with advanced renal cell carcinoma (RCC) using mass spectrometry-based (phospho) proteomics

Autor: Henk M.W. Verheul, Richard de Goeij de Haas, Mariette Labots, Jaco C. Knol, Thang V. Pham, Sander R. Piersma, Alex A. Henneman, Robin Beekhof, Hanneke van der Wijngaart, Connie R. Jimenez

Publikováno v: Journal of Clinical Oncology. 39:e16556-e16556

e16556 Background: Sunitinib, a multi-targeted antiangiogenic tyrosine kinase inhibitor has improved the outcome of patients with advanced RCC considerably. Unfortunately, ± 30% of patients are intrinsically resistant, which underscores the urgent n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a28c44226196106222e53f02c2f7d76
https://doi.org/10.1200/jco.2021.39.15_suppl.e16556

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Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

Publikováno v: Verweij, F J, Bebelman, M P, Jimenez, C R, Garcia-Vallejo, J J, Janssen, H, Neefjes, J, Knol, J C, de Goeij-de Haas, R, Piersma, S R, Baglio, S R, Verhage, M, Middeldorp, J M, Zomer, A, van Rheenen, J, Coppolino, M G, Hurbain, I, Raposo, G, Smit, M J, Toonen, R F G, van Niel, G & Pegtel, D M 2018, ' Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling ', Journal of Cell Biology, vol. 217, no. 3, pp. 1129-1142 . https://doi.org/10.1083/jcb.201703206
The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, 2018, 217 (3), pp.1129-1142. ⟨10.1083/jcb.201703206⟩
Journal of Cell Biology, 217(3), 1129-1142. Rockefeller University Press
Journal of Cell Biology, 217(3), 1129. Rockefeller University Press
Journal of Cell Biology, Rockefeller University Press, 2018, 217 (3), pp.1129-1142. ⟨10.1083/jcb.201703206⟩
Journal of Cell Biology, 217(3), 1129-1142

All mammalian cells release small endosome-derived exosomes that function in intercellular communication, but the secretion process is poorly understood. Verweij et al. developed a live-imaging approach and demonstrate that external cues can trigger

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d807d4f291bc079a77bc789b319fde04
https://hdl.handle.net/1871.1/091ce542-44c8-4022-aad1-3b7087ddd5f1

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