Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Richard Z Lin"'
Publikováno v:
Cells, Vol 13, Iss 12, p 1061 (2024)
Serine/threonine kinase AKT isoforms play a well-established role in cell metabolism and growth. Most pancreatic adenocarcinomas (PDACs) harbor activation mutations of KRAS, which activates the PI3K/AKT signaling pathway. However, AKT inhibitors are
Externí odkaz:
https://doaj.org/article/97da35a4a422476ebc5694cf615867be
Autor:
Kai Hou, Jianliang Shen, Junrong Yan, Chuannan Zhai, Jingxia Zhang, Ji-An Pan, Ye Zhang, Yaping Jiang, Yongbo Wang, Richard Z. Lin, Hongliang Cong, Shenglan Gao, Wei-Xing Zong
Publikováno v:
EBioMedicine, Vol 69, Iss , Pp 103456- (2021)
Background: Doxorubicin, an anthracycline chemotherapeutic agent, is widely used in the treatment of many cancers. However, doxorubicin posts a great risk of adverse cardiovascular events, which are thought to be caused by oxidative stress. We recent
Externí odkaz:
https://doaj.org/article/b1cffd1db963412989fa3db923dcbdbf
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
It has long been known that heart rate is regulated by the autonomic nervous system. Recently, we demonstrated that the pacemaker current, If, is regulated by phosphoinositide 3-kinase (PI3K) signaling independently of the autonomic nervous system. I
Externí odkaz:
https://doaj.org/article/4b0af37d918243b786b650aaacfa599c
Autor:
Rochelle K. Nelson, Jiang Ya-Ping, John Gadbery, Danya Abedeen, Nicole Sampson, Richard Z. Lin, Michael A. Frohman
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The Phospholipase D (PLD) superfamily is linked to neurological disease, cancer, and fertility, and a recent report correlated a potential loss-of-function PLD2 polymorphism with hypotension. Surprisingly, PLD2 −/− mice exhibit elevated
Externí odkaz:
https://doaj.org/article/42acf75c41c5480eb53ff6de77c917bc
Autor:
Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1287-1298.e6 (2019)
Summary: Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/surviv
Externí odkaz:
https://doaj.org/article/86935149469c4359a0a906c3024b9071
Autor:
Ying Luu, Imran Husain, Peng Yang, David Chu, Alan Kaell, Ira L. Cohen, Zhongju Lu, Jack Ip, Michael Lu, Chang-Kyung Kim, Richard Z. Lin
Publikováno v:
Journal of Community Hospital Internal Medicine Perspectives
article-version (VoR) Version of Record
Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 799-807 (2021)
article-version (VoR) Version of Record
Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 799-807 (2021)
Objective: To assess the prevalence of QTc prolongation in both non-diabetic and diabetic patients on TKIs. Some TKIs have been reported to cause QTc prolongation, which is prevalent in diabetes. However, there is no Risk Evaluation and Mitigation St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b9d8343a98267f626b89d7d958bb77
https://doi.org/10.1080/20009666.2021.1978652
https://doi.org/10.1080/20009666.2021.1978652
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176713 (2017)
Our previous work on angiotensin II-mediated electrical-remodeling in canine left ventricle, in connection with a long history of other studies, suggested the hypothesis: increases in mechanical load induce autocrine secretion of angiotensin II (A2),
Externí odkaz:
https://doaj.org/article/e53c587340894b349cc1ec19693a8488
Autor:
Richard Z Lin, Celine Gallagher, Samuel J Tu, Bradley M Pitman, Adam J Nelson, Ross L Roberts-Thomson, Matthew I Worthley, Dennis H Lau, Prashanthan Sanders, Christopher X Wong
Publikováno v:
Heart (British Cardiac Society).
ObjectivePrior data have shown rising acute myocardial infarction (MI) trends in Australia; whether these increases have continued in recent years is not known. This study thus sought to characterise contemporary nationwide trends in MI hospitalisati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9234bd36681dd32a6483bf2a8d85bf9d
https://pubmed.ncbi.nlm.nih.gov/36344268
https://pubmed.ncbi.nlm.nih.gov/36344268
Autor:
Kentaro Sahashi, Karen K. Y. Ling, Yimin Hua, John Erby Wilkinson, Tomoki Nomakuchi, Frank Rigo, Gene Hung, David Xu, Ya‐Ping Jiang, Richard Z. Lin, Chien‐Ping Ko, C. Frank Bennett, Adrian R. Krainer
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 10, Pp 1586-1601 (2013)
Abstract Loss‐of‐function mutations in SMN1 cause spinal muscular atrophy (SMA), a leading genetic cause of infant mortality. The related SMN2 gene expresses suboptimal levels of functional SMN protein, due to a splicing defect. Many SMA patients
Externí odkaz:
https://doaj.org/article/02f20b7d6ba64acfbfeeba4de2cef7d3
Autor:
Juei-Suei Chen, Kenneth Kaushansky, Ya-Ping Jiang, Melissa Castiglione, Haoyi Zheng, Sandy Lee, Wei Yin, Christopher Mazzeo, Richard Z. Lin, Huichun Zhan
Publikováno v:
Journal of Thrombosis and Haemostasis
Objective Cardiovascular complications are the leading cause of morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The acquired kinase mutation JAK2V617F plays a central role in these disorders. Mechanisms responsible for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf8dd951d09c27edc114941f1b712c1
http://europepmc.org/articles/PMC7756295
http://europepmc.org/articles/PMC7756295