Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Richard Yi-Tsun Kao"'
Autor:
Chenyuan Wang, Yushan Xia, Runming Wang, Jingru Li, Chun-Lung Chan, Richard Yi-Tsun Kao, Patrick H. Toy, Pak-Leung Ho, Hongyan Li, Hongzhe Sun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The rapid emergence of antimicrobial resistance (AMR) pathogens highlights the urgent need to approach this global burden with alternative strategies. Cefiderocol (Fetroja®) is a clinically-used sideromycin, that is utilized for the treatme
Externí odkaz:
https://doaj.org/article/c1898164917c40cdbcd6259a2256dd7e
Autor:
Peng Gao, Yuanxin Wei, Suying Hou, Pok-Man Lai, Han Liu, Sherlock Shing Chiu Tai, Victor Yat Man Tang, Pradeep Halebeedu Prakash, Kong-Hung Sze, Jonathan Hon Kwan Chen, Hongzhe Sun, Xuechen Li, Richard Yi-Tsun Kao
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Staphylococcus aureus is a major human pathogen responsible for a wide range of clinical infections. SaeRS is one of the two-component systems in S. aureus that modulate multiple virulence factors. Although SaeR is required for S. aureus to develop a
Externí odkaz:
https://doaj.org/article/5307efbe8a49412ab673ba50402d56c3
Autor:
Haibo Wang, Minji Wang, Xiaohan Xu, Peng Gao, Zeling Xu, Qi Zhang, Hongyan Li, Aixin Yan, Richard Yi-Tsun Kao, Hongzhe Sun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Silver (Ag) has been used as an antimicrobial agent since a long time, but its molecular mechanism of action was not elucidated due to technical challenges. Here, the authors develop a mass spectrometric approach to identify the Ag-proteome in Staphy
Externí odkaz:
https://doaj.org/article/793574555794407d804bad3dd59bbdde
Autor:
Hongzhe Sun, Qi Zhang, Runming Wang, Haibo Wang, Yuen-Ting Wong, Minji Wang, Quan Hao, Aixin Yan, Richard Yi-Tsun Kao, Pak-Leung Ho, Hongyan Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Multi-drug resistant pathogens remain a serious public health threat. Here, Sun and colleagues identify a role for auranofin, which is normally used as a drug for rheumatoid arthritis, for reversing antibiotic resistance to carbapenem and colistin.
Externí odkaz:
https://doaj.org/article/f7e57cb418f248e6bdad5f3c045c4159
Autor:
Jian Deng, Bao-zhong Zhang, Hin Chu, Xiao-lei Wang, Yixin Wang, Hua-Rui Gong, Renhao Li, Dong Yang, Cun Li, Ying Dou, Peng Gao, Jian-piao Cai, Meilin Jin, Qian Du, Jasper Fuk-Woo Chan, Richard Yi-Tsun Kao, Kwok-Yung Yuen, Jian-Dong Huang
Publikováno v:
EBioMedicine, Vol 70, Iss , Pp 103505- (2021)
Background: Staphylococcus aureus is a common human pathogen capable of causing diverse illnesses with possible recurrent infections. Although recent studies have highlighted the role of cellular immunity in recurrent infections, the mechanism by whi
Externí odkaz:
https://doaj.org/article/de7cd6d9ac834f5483f3034cef961878
Autor:
Shuofeng Yuan, Hin Chu, Jasper Fuk-Woo Chan, Zi-Wei Ye, Lei Wen, Bingpeng Yan, Pok-Man Lai, Kah-Meng Tee, Jingjing Huang, Dongdong Chen, Cun Li, Xiaoyu Zhao, Dong Yang, Man Chun Chiu, Cyril Yip, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kong-Hung Sze, Jie Zhou, Ivy Hau-Yee Chan, Kin-Hang Kok, Kelvin Kai-Wang To, Richard Yi-Tsun Kao, Johnson Yiu-Nam Lau, Dong-Yan Jin, Stanley Perlman, Kwok-Yung Yuen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the
Externí odkaz:
https://doaj.org/article/c1c5fe348ab54b8eb38874751717d9b6
Autor:
Li Zhu, Annie Wing-Tung Lee, Kelvin Ka-Lok Wu, Peng Gao, Kingsley King-Gee Tam, Rahim Rajwani, Galata Chala Chaburte, Timothy Ting-Leung Ng, Chloe Toi-Mei Chan, Hiu Yin Lao, Wing Cheong Yam, Richard Yi-Tsun Kao, Gilman Kit Hang Siu
Publikováno v:
Antibiotics, Vol 11, Iss 3, p 369 (2022)
The emergence of multidrug-resistant strains and hyper-virulent strains of Mycobacterium tuberculosis are big therapeutic challenges for tuberculosis (TB) control. Repurposing bioactive small-molecule compounds has recently become a new therapeutic a
Externí odkaz:
https://doaj.org/article/423ff6ac35df4bd99875f98dd272bdc1
Autor:
Runming Wang, Tsz-Pui Lai, Peng Gao, Hongmin Zhang, Pak-Leung Ho, Patrick Chiu-Yat Woo, Guixing Ma, Richard Yi-Tsun Kao, Hongyan Li, Hongzhe Sun
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Metallo-β-lactamases (MBL) are zinc containing enzymes that cause resistance to β-lactam antibiotics. Here the authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III),
Externí odkaz:
https://doaj.org/article/f323b829fd714274aab5e5072828f56c
Autor:
Haibo Wang, Minji Wang, Xiaohan Xu, Peng Gao, Zeling Xu, Qi Zhang, Hongyan Li, Aixin Yan, Richard Yi-Tsun Kao, Hongzhe Sun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/e5a0e9f0a0fa4a359a7565148792ad96
Autor:
Jian Deng, Xiaolei Wang, Bao-Zhong Zhang, Peng Gao, Qiubin Lin, Richard Yi-Tsun Kao, Kenth Gustafsson, Kwok-Yung Yuen, Jian-Dong Huang
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
ABSTRACT The demand for a prophylactic vaccine against methicillin-resistant Staphylococcus aureus (MRSA) has motivated numerous dedicated research groups to design and develop such a vaccine. In this study, we have developed a multivalent vaccine, S
Externí odkaz:
https://doaj.org/article/2c8355ae80914d0ebaedda23bd961a80