Zobrazeno 1 - 10
of 520
pro vyhledávání: '"Richard Yi"'
Autor:
Chenyuan Wang, Yushan Xia, Runming Wang, Jingru Li, Chun-Lung Chan, Richard Yi-Tsun Kao, Patrick H. Toy, Pak-Leung Ho, Hongyan Li, Hongzhe Sun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The rapid emergence of antimicrobial resistance (AMR) pathogens highlights the urgent need to approach this global burden with alternative strategies. Cefiderocol (Fetroja®) is a clinically-used sideromycin, that is utilized for the treatme
Externí odkaz:
https://doaj.org/article/c1898164917c40cdbcd6259a2256dd7e
Autor:
Peng Gao, Yuanxin Wei, Suying Hou, Pok-Man Lai, Han Liu, Sherlock Shing Chiu Tai, Victor Yat Man Tang, Pradeep Halebeedu Prakash, Kong-Hung Sze, Jonathan Hon Kwan Chen, Hongzhe Sun, Xuechen Li, Richard Yi-Tsun Kao
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Staphylococcus aureus is a major human pathogen responsible for a wide range of clinical infections. SaeRS is one of the two-component systems in S. aureus that modulate multiple virulence factors. Although SaeR is required for S. aureus to develop a
Externí odkaz:
https://doaj.org/article/5307efbe8a49412ab673ba50402d56c3
Autor:
Hanjun Zhao, Xinjie Meng, Zheng Peng, Hoiyan Lam, Chuyuan Zhang, Xinxin Zhou, Jasper Fuk-Woo Chan, Richard Yi Tsun Kao, Kelvin Kai-Wang To, Kwok-Yung Yuen
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 926-937 (2022)
Pandemic influenza virus and SARS-CoV-2 vaiants have posed major global threats to public health. Broad-spectrum antivirals blocking viral entry can be an effective strategy for combating these viruses. Here, we demonstrate a frog-defensin-derived ba
Externí odkaz:
https://doaj.org/article/a69e6e92bb824f269ca34c2743c4de0d
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291257 (2023)
ObjectiveAdolescents with fewer sources of environmental reinforcement may be at risk for alcohol use. Behavioral economic theories posit that engagement in some activities may facilitate alcohol use, whereas other activities may be incompatible with
Externí odkaz:
https://doaj.org/article/a8226e764f0d48c7b06bd31bbaf42e89
Autor:
Haibo Wang, Minji Wang, Xiaohan Xu, Peng Gao, Zeling Xu, Qi Zhang, Hongyan Li, Aixin Yan, Richard Yi-Tsun Kao, Hongzhe Sun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Silver (Ag) has been used as an antimicrobial agent since a long time, but its molecular mechanism of action was not elucidated due to technical challenges. Here, the authors develop a mass spectrometric approach to identify the Ag-proteome in Staphy
Externí odkaz:
https://doaj.org/article/793574555794407d804bad3dd59bbdde
Publikováno v:
Applied Sciences, Vol 13, Iss 6, p 3961 (2023)
Previous literature on deep learning theory has focused on implicit bias with small learning rates. In this work, we explore the impact of data separability on the implicit bias of deep learning algorithms under the large learning rate. Using deep li
Externí odkaz:
https://doaj.org/article/b955b31738db4a5b8b0c595710e1e937
Compositional Zero-Shot Learning (CZSL) aims to recognize novel \textit{state-object} compositions by leveraging the shared knowledge of their primitive components. Despite considerable progress, effectively calibrating the bias between semantically
Externí odkaz:
http://arxiv.org/abs/2408.08703
With the growing interest and applications in machine learning and data science, finding an efficient method to sparse analysis the high-dimensional data and optimizing a dimension reduction model to extract lower dimensional features has becoming mo
Externí odkaz:
http://arxiv.org/abs/2406.01885
Autor:
Hongzhe Sun, Qi Zhang, Runming Wang, Haibo Wang, Yuen-Ting Wong, Minji Wang, Quan Hao, Aixin Yan, Richard Yi-Tsun Kao, Pak-Leung Ho, Hongyan Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Multi-drug resistant pathogens remain a serious public health threat. Here, Sun and colleagues identify a role for auranofin, which is normally used as a drug for rheumatoid arthritis, for reversing antibiotic resistance to carbapenem and colistin.
Externí odkaz:
https://doaj.org/article/f7e57cb418f248e6bdad5f3c045c4159
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009807 (2022)
Estimating the changes of epidemiological parameters, such as instantaneous reproduction number, Rt, is important for understanding the transmission dynamics of infectious diseases. Current estimates of time-varying epidemiological parameters often f
Externí odkaz:
https://doaj.org/article/0cb7d6453f9e4cb9b09d1a215a73510b