Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Richard Yaacov Lawrence"'
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Akademický článek
Epidermal growth factor receptor (EGFR) mutation status and Rad51 determine the response of glioblastoma (GBM) to multimodality therapy with cetuximab, temozolomide and radiation
Autor: Phyllis Rachelle Wachsberger, Richard Yaacov Lawrence, Yi eLiu, Barbara eRice, Constantine eDaskalakis, Adam P Dicker
Publikováno v: Frontiers in Oncology, Vol 3 (2013)
Purpose: EGFR amplification and mutation (i.e., EGFRvIII) are found in 40% of primary GBM tumors and are believed to contribute to tumor development and therapeutic resistance. This study was designed to investigate how EGFR mutational status modulat
Externí odkaz: https://doaj.org/article/2744cd6261334a7495359d11320d5753
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2
Cediranib enhances control of wild type EGFR and EGFRvIII-expressing gliomas through potentiating temozolomide, but not through radiosensitization: implications for the clinic
Autor: Phyllis R. Wachsberger, Yi Liu, Richard Yaacov Lawrence, Barbara Andersen, Adam P. Dicker, Xu Xia
Publikováno v: Journal of Neuro-Oncology. 105:181-190
Glioblastomas (GBM) frequently overexpress the epidermal growth factor receptor (wtEGFR) or its mutant, EGFRvIII, contributing to chemo- and radioresistance. The current standard of care is surgery followed by radiation therapy with concurrent temozo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb40e9804be3c7202cedec232e553a2
https://doi.org/10.1007/s11060-011-0580-y
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3
Epidermal growth factor receptor (EGFR) mutation status and Rad51 determine the response of glioblastoma (GBM) to multimodality therapy with cetuximab, temozolomide and radiation
Autor: Richard Yaacov Lawrence, Yi Liu, Barbara Rice, Constantine Daskalakis, Phyllis R. Wachsberger, Adam P. Dicker
Publikováno v: Frontiers in Oncology, Vol 3 (2013)
Frontiers in Oncology
Purpose: EGFR amplification and mutation (i.e., EGFRvIII) are found in 40% of primary GBM tumors and are believed to contribute to tumor development and therapeutic resistance. This study was designed to investigate how EGFR mutational status modulat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d883692c7aed3ad0a7acba82f09d4c
http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00013/full
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4
Abstract 5719: Improvement of radiotherapy for glioblastoma by co-targeting PI3K and HSP90
Autor: Richard Yaacov Lawrence, Adam P. Dicker, Yi Liu, Barbara Andersen, Phyllis R. Wachsberger
Publikováno v: Cancer Research. 72:5719-5719
Introduction: Glioblastoma (GBM) tumors frequently contain mutations in the tumor suppressor gene, PTEN, leading to loss of PTEN activity. PTEN loss causes overactivation of the PI3K pathway, inducing inhibition of apoptosis and radioresistance. Heat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90e0e597f719af8a6203d019f74acf6b
https://doi.org/10.1158/1538-7445.am2012-5719
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Abstract 2662: Radiosensitizing potential of the PI3K inhibitor, BKM-120 and the HSP 90 inhibitor, HSP990, is dependent on PTEN status of glioblastoma cells
Autor: Yi Liu, Barbara Andersen, Richard Yaacov Lawrence, Nick Feo, Adam P. Dicker, Phyllis R. Wachsberger
Publikováno v: Cancer Research. 71:2662-2662
Introduction: Radiation therapy plays an essential role in the treatment of Glioblastoma Multiforme (GBM), the most common primary adult brain tumor. GBMs frequently contain mutations in the tumor suppressor gene, PTEN, a down regulator of the pro-su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f26373250a7b87266f6a2a69c6f7286
https://doi.org/10.1158/1538-7445.am2011-2662
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