Výsledky vyhledávání - "Richard Y. Lee"

High-Dose Proton Beam-Based Radiation Therapy in the Management of Extracranial Chondrosarcomas

Autor: Petur Nielsen, A. Jacobson, Joseph H. Schwab, Aashish D. Bhatt, Thomas F. DeLaney, David C. Harmon, Yen-Lin Chen, Richard Y. Lee, Francis J. Hornicek, C. Giraud, Edwin Choy

Publikováno v: International journal of particle therapy. 3(3)

Purpose: Radiation therapy (RT) improves local tumor control in axial chondrosarcomas (CS). It is, however, often difficult to safely deliver the high doses (range, 70.2-77.4 Gy) required for achieving a high likelihood of local control, especially i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69461bf9c42b2d97d30026621c44b331
https://pubmed.ncbi.nlm.nih.gov/31772986

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Gene Signaling Pathways Mediating the Opposite Effects of Prepubertal Low-Fat and High-Fat n-3 Polyunsaturated Fatty Acid Diets on Mammary Cancer Risk

Autor: Anna Cabanes, Yuelin Zhu, Richard Y. Lee, Leena Hilakivi-Clarke, Robert Clarke, Susan Olivo-Marston, Yue Wang, Galam Khan, Alan Zwart

Publikováno v: Cancer Prevention Research. 1:532-545

In rats, prepubertal exposure to low-fat diet containing n-3 polyunsaturated fatty acids (PUFA) reduces mammary cell proliferation, increases apoptosis, and lowers risk of mammary tumors in adulthood, whereas prepubertal high-fat n-3 PUFA exposure ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2e3b381ec367999551eef656ac61fe
https://doi.org/10.1158/1940-6207.capr-08-0030

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Evaluation of gene expression profile of keratinocytes in response to JP-8 jet fuel

Autor: A. Hamid Boulares, Yue Wang, Peijun Li, Luis A. Espinoza, Richard Y. Lee, Robert Clarke, Mark E. Smulson

Publikováno v: Toxicology and Applied Pharmacology. 200:93-102

The skin is the principal barrier against any environmental insult. Therefore, there is a high risk for a large number of military and civilian personnel exposed to jet fuel JP-8 to suffer percutaneous absorption of this fuel. This paper reports the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765b2ebfd44f143cbeee2add45c21460
https://doi.org/10.1016/j.taap.2004.03.022

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Discriminatory Mining of Gene Expression Microarray Data

Autor: Jianping Lu, Javed Khan, Richard Y. Lee, Junying Zhang, Zuyi Wang, Sun-Yuan Kung, Robert Clarke, Jianhua Xuan, Yue Wang

Publikováno v: The Journal of VLSI Signal Processing-Systems for Signal, Image, and Video Technology. 35:255-272

Recent advances in machine learning and pattern recognition methods provide new analytical tools to explore high dimensional gene expression microarray data. Our data mining software, VISual Data Analyzer for cluster discovery (VISDA), reveals many d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53cd5e55e896304b2528598ed4fc1414
https://doi.org/10.1023/b:vlsi.0000003024.13494.40

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Constitutive Expression of the Steroid Sulfatase Gene Supports the Growth of MCF-7 Human Breast Cancer Cells in Vitroand in Vivo*

Autor: Mattie R. James, Alexander MacPherson, James A. Zwiebel, Todd C. Skaar, Richard Y. Lee, Robert Clarke, Franklin Ampy, Balwant S. Ahluwalia

Publikováno v: Endocrinology. 142:1497-1505

Many human breast tumors are driven by high intratumor concentrations of 17beta-estradiol that appear to be locally synthesized. The role of aromatase is well established, but the possible contribution of the steroid sulfatase (STS), which liberates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0004dee83db26443d28244cc10a2fbf
https://doi.org/10.1210/endo.142.4.8091

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Estrogen receptor alpha positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures

Autor: Richard Y. Lee, Minetta C. Liu, Yuelin Zhu, Ann Gallagher, Antai Wang, J Michael Dixon, William R. Miller, Robert Clarke, Yue Wang, Alan Zwart

Publikováno v: Europe PubMed Central
Scopus-Elsevier

Established human breast cancer cell lines are widely used as experimental models in breast cancer research. While these cell lines and their variants share many phenotypic characteristics with human breast tumors, the extent to which they reflect th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a702d9920d95fa23c711f9d47463709
https://doi.org/10.3892/ijo.29.6.1581

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Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling

Autor: Kerrie B. Bouker, Minetta C. Liu, Kerry A. O’Brien, Yuelin Zhu, Richard Y. Lee, Bianca P. Gomez, Robert Clarke, Todd C. Skaar, Leena Hilakivi-Clarke, Yue Wang, Zhiping Gu

Publikováno v: Oncogene. 22(47)

Antiestrogens include agents such as tamoxifen, toremifene, raloxifene, and fulvestrant. Currently, tamoxifen is the only drug approved for use in breast cancer chemoprevention, and it remains the treatment of choice for most women with hormone recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676018dc76bc47f6d35c7021bd047818
https://pubmed.ncbi.nlm.nih.gov/14576841

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Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780)

Autor: Zhiping, Gu, Richard Y, Lee, Todd C, Skaar, Kerrie B, Bouker, James N, Welch, Jianping, Lu, Aiyi, Liu, Yuelin, Zhu, Natalie, Davis, Fabio, Leonessa, Nils, Brünner, Yue, Wang, Robert, Clarke

Publikováno v: Cancer research. 62(12)

To identify genes associated with survival from antiestrogens, both serial analysis of geneexpression and gene expression microarrays were used to explore the transcriptomes of antiestrogen-responsive (MCF7/LCC1) and -resistant variants(MCF7/LCC9) of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd520958512ec3eb1be0e345a8047c0f
https://pubmed.ncbi.nlm.nih.gov/12067985

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The Role of RARalpha Coregulators in Resistance to Vitamin A and Synthetic Retinoids

Autor: Richard Y. Lee

Retinoids, analogs of Vitamin A, inhibit breast cancer cell proliferation through receptors in the super-family of nuclear transcriptional factors. 9-cis retinoic acid (9-cis-RA) is a retinoid pan agonist that activates both RAR and RXR isoforms. N-(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650d29169cd64cc50c9f6142e664f1cb
https://doi.org/10.21236/ada383094

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