Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Richard Y. Ebright"'
Autor:
Douglas B. Fox, Richard Y. Ebright, Xin Hong, Hunter C. Russell, Hongshan Guo, Thomas J. LaSalle, Ben S. Wittner, Nicolas Poux, Joanna A. Vuille, Mehmet Toner, Nir Hacohen, Genevieve M. Boland, Debattama R. Sen, Ryan J. Sullivan, Shyamala Maheswaran, Daniel A. Haber
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-7 (2023)
Abstract Immune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional characterizatio
Externí odkaz:
https://doaj.org/article/0c4c7c44430b4c2d974ab834570483bb
Autor:
Richard Y. Ebright, Marcus A. Zachariah, Douglas S. Micalizzi, Ben S. Wittner, Kira L. Niederhoffer, Linda T. Nieman, Brian Chirn, Devon F. Wiley, Benjamin Wesley, Brian Shaw, Edwin Nieblas-Bedolla, Lian Atlas, Annamaria Szabolcs, Anthony J. Iafrate, Mehmet Toner, David T. Ting, Priscilla K. Brastianos, Daniel A. Haber, Shyamala Maheswaran
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The mechanisms underlying the growth of breast cancer metastasis in the brain are unclear. Here, the authors use an intracranial injection mouse model and single-cell analysis of patient circulating tumour cells to demonstrate that increased hypoxic
Externí odkaz:
https://doaj.org/article/54abe4889e2240aa9d1bd7861d09df2e
Autor:
David T. Ting, Benjamin D. Greenbaum, Peter J. Park, Kathleen H. Burns, David R. Walt, Shelley L. Berger, Theodore S. Hong, Martin J. Aryee, Miguel N. Rivera, Vikram Deshpande, Ryan B. Corcoran, David P. Ryan, Jennifer Y. Wo, Lipika Goyal, Jeffrey W. Clark, Lawrence S. Blaszkowsky, Jill N. Allen, Hui Zheng, Yasmeen Senussi, Padric M. Garden, Limor Cohen, Vishal Thapar, Matteo Ligorio, Kshitij S. Arora, Niyati Desai, Linda T. Nieman, Michael J. Raabe, Jasmin Joseph-Chazan, Chenyue Lu, Eric C. Tai, Kevin D. Vo, Emily E. Van Seventer, Richard Y. Ebright, Nova Xu, Antuan V. Tran, Stefanie Gerstberger, Annamaria Szabolcs, Charly R. Good, Katherine A. Alexander, Connie Wu, Martin S. Taylor, Christopher Jaicks, Katherine H. Xu, Chong Chu, Anupriya S. Kulkarni, Eunae You, Alexander Solovyov, Aparna R. Parikh, Mihir Rajurkar
Altered RNA expression of repetitive sequences and retrotransposition are frequently seen in colorectal cancer, implicating a functional importance of repeat activity in cancer progression. We show the nucleoside reverse transcriptase inhibitor 3TC t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872fbbb37783ee4cbd8e559e5d98142a
https://doi.org/10.1158/2159-8290.c.6549619.v1
https://doi.org/10.1158/2159-8290.c.6549619.v1
Autor:
David T. Ting, Benjamin D. Greenbaum, Peter J. Park, Kathleen H. Burns, David R. Walt, Shelley L. Berger, Theodore S. Hong, Martin J. Aryee, Miguel N. Rivera, Vikram Deshpande, Ryan B. Corcoran, David P. Ryan, Jennifer Y. Wo, Lipika Goyal, Jeffrey W. Clark, Lawrence S. Blaszkowsky, Jill N. Allen, Hui Zheng, Yasmeen Senussi, Padric M. Garden, Limor Cohen, Vishal Thapar, Matteo Ligorio, Kshitij S. Arora, Niyati Desai, Linda T. Nieman, Michael J. Raabe, Jasmin Joseph-Chazan, Chenyue Lu, Eric C. Tai, Kevin D. Vo, Emily E. Van Seventer, Richard Y. Ebright, Nova Xu, Antuan V. Tran, Stefanie Gerstberger, Annamaria Szabolcs, Charly R. Good, Katherine A. Alexander, Connie Wu, Martin S. Taylor, Christopher Jaicks, Katherine H. Xu, Chong Chu, Anupriya S. Kulkarni, Eunae You, Alexander Solovyov, Aparna R. Parikh, Mihir Rajurkar
Supplementary Figure from Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba166183bd8c52fab4bd2fa1beca42eb
https://doi.org/10.1158/2159-8290.22541353.v1
https://doi.org/10.1158/2159-8290.22541353.v1
Autor:
David T. Ting, Benjamin D. Greenbaum, Peter J. Park, Kathleen H. Burns, David R. Walt, Shelley L. Berger, Theodore S. Hong, Martin J. Aryee, Miguel N. Rivera, Vikram Deshpande, Ryan B. Corcoran, David P. Ryan, Jennifer Y. Wo, Lipika Goyal, Jeffrey W. Clark, Lawrence S. Blaszkowsky, Jill N. Allen, Hui Zheng, Yasmeen Senussi, Padric M. Garden, Limor Cohen, Vishal Thapar, Matteo Ligorio, Kshitij S. Arora, Niyati Desai, Linda T. Nieman, Michael J. Raabe, Jasmin Joseph-Chazan, Chenyue Lu, Eric C. Tai, Kevin D. Vo, Emily E. Van Seventer, Richard Y. Ebright, Nova Xu, Antuan V. Tran, Stefanie Gerstberger, Annamaria Szabolcs, Charly R. Good, Katherine A. Alexander, Connie Wu, Martin S. Taylor, Christopher Jaicks, Katherine H. Xu, Chong Chu, Anupriya S. Kulkarni, Eunae You, Alexander Solovyov, Aparna R. Parikh, Mihir Rajurkar
Supplementary Data from Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018c5f6d63f7683d1f8bf491b8daa6e0
https://doi.org/10.1158/2159-8290.22541365.v1
https://doi.org/10.1158/2159-8290.22541365.v1
Autor:
Mihir Rajurkar, Aparna R. Parikh, Alexander Solovyov, Eunae You, Anupriya S. Kulkarni, Chong Chu, Katherine H. Xu, Christopher Jaicks, Martin S. Taylor, Connie Wu, Katherine A. Alexander, Charly R. Good, Annamaria Szabolcs, Stefanie Gerstberger, Antuan V. Tran, Nova Xu, Richard Y. Ebright, Emily E. Van Seventer, Kevin D. Vo, Eric C. Tai, Chenyue Lu, Jasmin Joseph-Chazan, Michael J. Raabe, Linda T. Nieman, Niyati Desai, Kshitij S. Arora, Matteo Ligorio, Vishal Thapar, Limor Cohen, Padric M. Garden, Yasmeen Senussi, Hui Zheng, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffrey W. Clark, Lipika Goyal, Jennifer Y. Wo, David P. Ryan, Ryan B. Corcoran, Vikram Deshpande, Miguel N. Rivera, Martin J. Aryee, Theodore S. Hong, Shelley L. Berger, David R. Walt, Kathleen H. Burns, Peter J. Park, Benjamin D. Greenbaum, David T. Ting
Publikováno v:
Cancer Discov
Altered RNA expression of repetitive sequences and retrotransposition are frequently seen in colorectal cancer, implicating a functional importance of repeat activity in cancer progression. We show the nucleoside reverse transcriptase inhibitor 3TC t
Autor:
Eunae You, Ildiko Phillips E. Phillips, Richard Y. Ebright, Niyati Desai, Michael J. Raabe, Evan R. Lang, Linda T. Nieman, Soroush Hajizadeh, Johannes Kreuzer, Wilhelm Haas, David T. Ting
Publikováno v:
Cancer Research. 82:A066-A066
Transcriptional profiling has defined PDAC into distinct classical epithelial (E) or quasi-mesenchymal (QM) subtypes, and these subtypes exist on a continuum of interconverting cell states. This epithelial to mesenchymal transition (EMT) plasticity i
Autor:
Brian Chirn, Annamaria Szabolcs, Benjamin Wesley, Devon F. Wiley, Marcus A. Zachariah, David T. Ting, Daniel A. Haber, Edwin Nieblas-Bedolla, Shyamala Maheswaran, Lian Atlas, Kira L. Niederhoffer, Linda T. Nieman, Anthony J. Iafrate, Douglas S. Micalizzi, Brian A. Shaw, Ben S. Wittner, Mehmet Toner, Priscilla K. Brastianos, Richard Y. Ebright
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Blood-borne metastasis to the brain is a major complication of breast cancer, but cellular pathways that enable cancer cells to selectively grow in the brain microenvironment are poorly understood. We find that cultured circulating tumor cells (CTCs)
Autor:
Elad Horwitz, Joanna A. Vuille, Ben S. Wittner, Devon F. Wiley, Xin Hong, Taronish D. Dubash, Shyamala Maheswaran, Kira L. Niederhoffer, Soroush Hajizadeh, Michael S. Lawrence, Shobha Vasudevan, Risa Burr, Linda T. Nieman, Uyen Ho, Adam Langenbucher, Raul Mostoslavsky, Lee Zou, Benjamin Wesley, Richard Y. Ebright, Jia-Min Zhang, Hongshan Guo, Chenyue Lu, Valentine Comaills, Marcus A. Zachariah, Daniel A. Haber, Gabriel Golczer, Brittany A. Reeves, Mehmet Toner
Publikováno v:
Mol Cell
Summary Deregulation of oncogenic signals in cancer triggers replication stress. Immediate early genes (IEGs) are rapidly and transiently expressed following stressful signals, contributing to an integrated response. Here, we find that the orphan nuc
Publikováno v:
Cancer Res
Deregulation of the mRNA translational process has been observed during tumorigenesis. However, recent findings have shown that deregulation of translation also contributes specifically to cancer cell spread. During metastasis, cancer cells undergo c