Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.

Autor: Michelle K Lupton, Petroula Proitsi, Makrina Danillidou, Magda Tsolaki, Gillian Hamilton, Richard Wroe, Megan Pritchard, Kathryn Lord, Belinda M Martin, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Denise Harold, Paul Hollingworth, Simon Lovestone, John F Powell

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e17298 (2011)

Nicastrin is an obligatory component of the γ-secretase; the enzyme complex that leads to the production of Aβ fragments critically central to the pathogenesis of Alzheimer's disease (AD). Analyses of the effects of common variation in this gene on

Externí odkaz: https://doaj.org/article/23a00884875846cc8154fa1c9d1e808c

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

Autor: Chantelle Fernandes, John Stephenson, Karelle Leroy, Alessia Usardi, Anbarasu Lourdusamy, Richard Williamson, Patrick M. Nolan, Elena M. Ribe, Wendy Noble, Angela Hodges, Christopher A. Reynolds, Richard Wroe, Chantal Bazenet, Claudie Hooper, Mirsada Causevic, Stuart Kellie, Alvina W.M. To, J-P. Brion, Raya Al-Shawi, Simon Lovestone, Katie Lunnon, Gerome Breen, Richard Dobson, Martha Robinson, J. Paul Simons, Simon J. Furney, Richard Killick, Kuang Lin, Bilal Malik

Publikováno v: Molecular psychiatry, 19 (1
Molecular Psychiatry
Killick, R, Ribe, E M, Al-Shawi, R, Malik, B, Hooper, C, Fernandes, C, Dobson, R, Nolan, P M, Lourdusamy, A, Furney, S, Lin, K, Breen, G, Wroe, R, To, A W M, Leroy, K, Causevic, M, Usardi, A, Robinson, M, Noble, W, Williamson, R, Lunnon, K, Kellie, S, Reynolds, C H, Bazenet, C, Hodges, A, Brion, J-P, Stephenson, J, Paul Simons, J & Lovestone, S 2014, ' Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway ', Molecular Psychiatry, vol. 19, no. 1, pp. 88-98 . https://doi.org/10.1038/mp.2012.163

Although the mechanism of Aβ action in the pathogenesis of Alzheimer's disease (AD) has remained elusive, it is known to increase the expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the silencing of Dkk1 blocks A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d852d2e28fab1f69dcf47924b534aa
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/132854

Meta-analysis of linkage studies for Alzheimer's disease--a web resource

Autor: Mandy Y.M. Ng, Richard Wroe, Amy W. Butler, Paola Forabosco, Ammar Al-Chalabi, Marian L. Hamshere, John Powell, Cathryn M. Lewis

Publikováno v: Neurobiology of aging. 30(7)

Familial late-onset Alzheimer's disease (LOAD) shows high heritability. However, with the exception of ApoE, no well-replicated susceptibility genes have been identified to date. Several genome-wide linkage studies have nominated potential susceptibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a862ebc15e583c2f7dfe27c8bd1de436
https://pubmed.ncbi.nlm.nih.gov/19362756

Comparing Folding Codes in Simple Heteropolymer Models of Protein Evolutionary Landscape: Robustness of the Superfunnel Paradigm

Autor: Richard Wroe, Erich Bornberg-Bauer, Hue Sun Chan

Understanding the evolution of biopolymers is a key element in rationalizing their structures and functions. Simple exact models (SEMs) are well-positioned to address general principles of evolution as they permit the exhaustive enumeration of both s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1882001ebb340d7cea7d46ab49f50b
https://europepmc.org/articles/PMC1304991/