Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Richard Weindruch"'
Autor:
Julie A. Mattison, Ricki J. Colman, T. Mark Beasley, David B. Allison, Joseph W. Kemnitz, George S. Roth, Donald K. Ingram, Richard Weindruch, Rafael de Cabo, Rozalyn M. Anderson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Caloric restriction (CR) delays ageing of model organisms, but whether it works in nonhuman primates has been controversial. Here, the authors pool and reanalyse data from two long-running CR primate studies, concluding that moderate CR indeed improv
Externí odkaz:
https://doaj.org/article/3a76c66b68f7460284eef313ff046d21
Autor:
Shinichi Someya, Gregory C Kujoth, Mi-Jung Kim, Timothy A Hacker, Marc Vermulst, Richard Weindruch, Tomas A Prolla
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171159 (2017)
Mitochondrial DNA (mtDNA) mutations are thought to have a causative role in age-related pathologies. We have shown previously that mitochondrial mutator mice (PolgD257A/D257A), harboring a proofreading-deficient version of the mtDNA polymerase gamma
Externí odkaz:
https://doaj.org/article/d0cf2fabc2cc46abae69badfebb375fe
Autor:
Sunil Kochhar, Tomas A. Prolla, Richard Weindruch, Laeticia Da Silva, Ivan Montoliu, Jamie L. Barger, François-Pierre J. Martin, Sebastiano Collino
Publikováno v:
Metabolites, Vol 3, Iss 4, Pp 881-911 (2013)
Calorie restriction (CR) has long been used to study lifespan effects and oppose the development of a broad array of age-related biological and pathological changes (increase healthspan). Yet, a comprehensive comparison of the metabolic phenotype acr
Externí odkaz:
https://doaj.org/article/d85efb2cd74649b28e130619f2c1da4c
Autor:
Jamie L Barger, Rozalyn M Anderson, Michael A Newton, Cristina da Silva, James A Vann, Thomas D Pugh, Shinichi Someya, Tomas A Prolla, Richard Weindruch
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120738 (2015)
Aging is the most significant risk factor for a range of diseases, including many cancers, neurodegeneration, cardiovascular disease, and diabetes. Caloric restriction (CR) without malnutrition delays aging in diverse species, and therefore offers un
Externí odkaz:
https://doaj.org/article/979cd6779f6848da91ee85328ec8a68f
Autor:
Jamie L Barger, Tsuyoshi Kayo, James M Vann, Edward B Arias, Jelai Wang, Timothy A Hacker, Ying Wang, Daniel Raederstorff, Jason D Morrow, Christiaan Leeuwenburgh, David B Allison, Kurt W Saupe, Gregory D Cartee, Richard Weindruch, Tomas A Prolla
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2264 (2008)
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose
Externí odkaz:
https://doaj.org/article/e25f222114b3420ba995866183387c34
Autor:
Jamie L. Barger, Tsuyoshi Kayo, James M. Vann, Edward B. Arias, Jelai Wang, Timothy A. Hacker, Ying Wang, Daniel Raederstorff, Jason D. Morrow, Christiaan Leeuwenburgh, David B. Allison, Kurt W. Saupe, Gregory D. Cartee, Richard Weindruch, Tomas A. Prolla
Publikováno v:
PLoS ONE, Vol 3, Iss 6 (2008)
Externí odkaz:
https://doaj.org/article/f1293afcf7d047bdae4f5d2df6381ee4
Publikováno v:
The Scientific World Journal, Vol 1, Pp 85-85 (2001)
Externí odkaz:
https://doaj.org/article/b5bf4365a3794e529272c686d0019e17
Autor:
David F. Jarrard, Richard Weindruch, John Svaren, Mark Berres, Rajini Srinivasan, Jonathan A. Ewald, Nima Almassi, Joshua A. Desotelle, Joseph R. Dobosy, Vivian X. Fu
Supplementary Figures 1-2 from Aging and Cancer-Related Loss of Insulin-like Growth Factor 2 Imprinting in the Mouse and Human Prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e523243b5790625bf479da8e9c2b4d
https://doi.org/10.1158/0008-5472.22377275.v1
https://doi.org/10.1158/0008-5472.22377275.v1
Autor:
Steven M. Wood, Richard Weindruch, Nicole L. Cray, Shelly N. Hester, Jamie L. Barger, Tomas A. Prolla, Angela Mastaloudis, James M. Vann, Michael A. Newton, Thomas D. Pugh
Publikováno v:
Aging Cell
Summary Caloric restriction (CR) without malnutrition has been shown to retard several aspects of the aging process and to extend lifespan in different species. There is strong interest in the identification of CR mimetics (CRMs), compounds that mimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6958163803b571316cf80761c2f8707
https://doi.org/10.1111/acel.12608
https://doi.org/10.1111/acel.12608
Autor:
Ricki J. Colman, Donald K. Ingram, Julie A. Mattison, Richard Weindruch, T. Mark Beasley, Joseph W. Kemnitz, George S. Roth, Rozalyn M. Anderson, David B. Allison, Rafael de Cabo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact in nonhuman primates has been controversial. In the late 1980s two parallel studies were initiated to determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f621dff6e74158213ac3cdb965ca4695
https://doaj.org/article/3a76c66b68f7460284eef313ff046d21
https://doaj.org/article/3a76c66b68f7460284eef313ff046d21