Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Richard Weightman"'
Autor:
Oliver Thompson, Ferdinand von Meyenn, Zoe Hewitt, John Alexander, Andrew Wood, Richard Weightman, Sian Gregory, Felix Krueger, Simon Andrews, Ivana Barbaric, Paul J. Gokhale, Harry D. Moore, Wolf Reik, Marta Milo, Serena Nik-Zainal, Kosuke Yusa, Peter W. Andrews
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutations in human pluripotent stem cells (PSC) and whether any form during culture prior to use in a human clinical context are a concern. Here, the authors use hPSCs derived to cGMP standards and show they have low mutation rates after culture, not
Externí odkaz:
https://doaj.org/article/6f55e007701f4013b3a7b971436b8888
Autor:
Irene Canton, Nicholas J. Warren, Aman Chahal, Katherine Amps, Andrew Wood, Richard Weightman, Eugenia Wang, Harry Moore, Steven P. Armes
Publikováno v:
ACS Central Science, Vol 2, Iss 2, Pp 65-74 (2016)
Externí odkaz:
https://doaj.org/article/c445e6eb35ec4deabfaa40be69c78c41
Autor:
John Alexander, Ivana Barbaric, Zoe Hewitt, Sian Gregory, Wolf Reik, Peter W. Andrews, Richard Weightman, Harry Moore, Simon Andrews, Oliver Thompson, Serena Nik-Zainal, Andrew Wood, Felix Krueger, Kosuke Yusa, Paul J. Gokhale, Ferdinand von Meyenn, Marta Milo
Publikováno v:
Nature Communications, 11 (1)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
The occurrence of repetitive genomic changes that provide a selective growth advantage in pluripotent stem cells is of concern for their clinical application. However, the effect of different culture conditions on the underlying mutation rate is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cfb1b92a9f0c24212fc9fb13395214
https://www.repository.cam.ac.uk/handle/1810/319113
https://www.repository.cam.ac.uk/handle/1810/319113
Publikováno v:
Biochemical and Biophysical Research Communications. 473:758-763
Autophagy is an important conserved cellular process, both constitutively as a recycling pathway for long lived proteins and as an upregulated stress response. Recent findings suggest a fundamental role for autophagic processes in the maintenance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9528fb71f6af10240745e70a5224c92a
https://doi.org/10.1016/j.bbrc.2015.09.080
https://doi.org/10.1016/j.bbrc.2015.09.080
Autor:
Richard Weightman, Irene Canton, Andrew Wood, Aman Chahal, Katherine Amps, Harry Moore, Nicholas J. Warren, Eugenia Wang, Steven P. Armes
Publikováno v:
ACS Central Science
ACS Central Science, Vol 2, Iss 2, Pp 65-74 (2016)
ACS Central Science, Vol 2, Iss 2, Pp 65-74 (2016)
Human pluripotent stem cells (hPSCs; both embryonic and induced pluripotent) rapidly proliferate in adherent culture to maintain their undifferentiated state. However, for mammals exhibiting delayed gestation (diapause), mucin-coated embryos can rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b47a19e91853547ddffbae10284ec5