Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Richard Wade-Martins"'
Autor:
Quyen B. Do, Humaira Noor, Ricardo Marquez-Gomez, Kaitlyn M. L. Cramb, Bryan Ng, Ajantha Abbey, Naroa Ibarra-Aizpurua, Maria Claudia Caiazza, Parnaz Sharifi, Charmaine Lang, Dayne Beccano-Kelly, Jimena Baleriola, Nora Bengoa-Vergniory, Richard Wade-Martins
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Understanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of the basal ganglia. Here, we developed a custom three-chambered microfluidic platform and
Externí odkaz:
https://doaj.org/article/97680562b37f462c955fb032be5c6fe7
Autor:
Peter Kilfeather, Jia Hui Khoo, Katherina Wagner, Han Liang, Maria Claudia Caiazza, Yanru An, Xingju Zhang, Xiaoyan Chen, Natalie Connor-Robson, Zhouchun Shang, Richard Wade-Martins
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113784- (2024)
Summary: The brain is spatially organized and contains unique cell types, each performing diverse functions and exhibiting differential susceptibility to neurodegeneration. This is exemplified in Parkinson’s disease with the preferential loss of do
Externí odkaz:
https://doaj.org/article/4ebe33e7041b43bf91b808663636389d
Autor:
Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward, Ling Hao
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-19 (2023)
Abstract Background Progranulin (PGRN) is a lysosomal glycoprotein implicated in various neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid lipofuscinosis. Over 70 mutations discovered in the GRN gene all result in redu
Externí odkaz:
https://doaj.org/article/ae3e17116c4b4fa5a12ef111d84e132a
Autor:
Björn F. Vahsen, Sumedha Nalluru, Georgia R. Morgan, Lucy Farrimond, Emily Carroll, Yinyan Xu, Kaitlyn M. L. Cramb, Benazir Amein, Jakub Scaber, Antigoni Katsikoudi, Ana Candalija, Mireia Carcolé, Ruxandra Dafinca, Adrian M. Isaacs, Richard Wade-Martins, Elizabeth Gray, Martin R. Turner, Sally A. Cowley, Kevin Talbot
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic v
Externí odkaz:
https://doaj.org/article/3d51552885d24a2f94bd75e36ffa3438
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-23 (2023)
Abstract Friedreich ataxia (FRDA) is a rare genetic multisystem disorder caused by a pathological GAA trinucleotide repeat expansion in the FXN gene. The numerous drawbacks of historical cellular and rodent models of FRDA have caused difficulty in pe
Externí odkaz:
https://doaj.org/article/6038bcaa76ab4b6ea1eec2009ea2a8d1
Autor:
Dayne A. Beccano-Kelly, Marta Cherubini, Yassine Mousba, Kaitlyn M.L. Cramb, Stefania Giussani, Maria Claudia Caiazza, Pavandeep Rai, Siv Vingill, Nora Bengoa-Vergniory, Bryan Ng, Gabriele Corda, Abhirup Banerjee, Jane Vowles, Sally Cowley, Richard Wade-Martins
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107044- (2023)
Summary: Parkinson’s disease (PD) is characterized by a progressive deterioration of motor and cognitive functions. Although death of dopamine neurons is the hallmark pathology of PD, this is a late-stage disease process preceded by neuronal dysfun
Externí odkaz:
https://doaj.org/article/f5a07e41be014a9c8bc7c3737d815059
Autor:
Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward, Ling Hao
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/10b8a1553d0b4966a9c5ea4d64af7dbf
Autor:
Björn F. Vahsen, Elizabeth Gray, Ana Candalija, Kaitlyn M. L. Cramb, Jakub Scaber, Ruxandra Dafinca, Antigoni Katsikoudi, Yinyan Xu, Lucy Farrimond, Richard Wade-Martins, William S. James, Martin R. Turner, Sally A. Cowley, Kevin Talbot
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Motor neuron diseases such as amyotrophic lateral sclerosis are primarily characterized by motor neuron degeneration with additional involvement of non-neuronal cells, in particular, microglia. In previous work, we have established protocols
Externí odkaz:
https://doaj.org/article/db218578cfca489c825f444402cee380
Autor:
Helle Bogetofte, Brent J. Ryan, Pia Jensen, Sissel I. Schmidt, Dana L.E. Vergoossen, Mike B. Barnkob, Lisa N. Kiani, Uroosa Chughtai, Rachel Heon-Roberts, Maria Claudia Caiazza, William McGuinness, Ricardo Márquez-Gómez, Jane Vowles, Fiona S. Bunn, Janine Brandes, Peter Kilfeather, Jack P. Connor, Hugo J.R. Fernandes, Tara M. Caffrey, Morten Meyer, Sally A. Cowley, Martin R. Larsen, Richard Wade-Martins
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112180- (2023)
Summary: Variants at the GBA locus, encoding glucocerebrosidase, are the strongest common genetic risk factor for Parkinson’s disease (PD). To understand GBA-related disease mechanisms, we use a multi-part-enrichment proteomics and post-translation
Externí odkaz:
https://doaj.org/article/82feb45f7a544f64addd016b4fe4a636
Autor:
Sarah Burley, Dayne A. Beccano-Kelly, Kevin Talbot, Oscar Cordero Llana, Richard Wade-Martins
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract A large hexanucleotide repeat expansion in the C9ORF72 gene is the most prevalent cause of amyotrophic lateral sclerosis (ALS). To better understand neuronal dysfunction during ALS progression, we studied motor neuron (MN) cultures derived f
Externí odkaz:
https://doaj.org/article/b6808073b3ad4007bfe5743a128efd85